ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Our new paper "Interpretable machine learning identifies an emergent absence seizure mechanism" biorxiv.org/content/10.1101/… expertly lead by Jacob Hull in collaboration with John Huguenard.
We identify a highly accurate yet interpretable dynamical systems model of how the brain transitions into a seizure state that leads to loss of consciousness through distributed network chaos.
Our model makes predictions: when certain pairs of brain regions oscillate at a preferred phase lag, seizure amplitude grows - and at the opposite phase lag it does not.
We confirmed these predictions using paired optogenetic stimulation of these brain regions at all phase lags.
This shows how we can combine neural recordings, machine learning models of them, and interpretabilty analyses of such models, to derive both conceptual insight and new nonintuitive experimental predictions, which can then be tested with theory driven stimulation designs. This is a powerful path forward for systems neuroscience in general.
In particular, our study showed that a distributed somatosensory-motor-thalamic network is critical for ongoing consciousness: both hypoactivity (through anesthesia) and hyperactivity (through chaos in seizures) in this circuit lead to loss of consciousness.
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Are virtual flies playing Beat Saber? SM64? Doom? No.
The new fly connectome is an incredible achievement! Less is going on in the sim videos than it seems. I'm stoked to see people engage with neuroscience though. My breakdown: neuroai.science/p/are-flies-…
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
We're offering grants of up to $50,000 in Claude usage credits to researchers accelerating cures for rare diseases.
This is our first focused call within AI for Science, our program supporting scientists using Claude to speed up discovery. anthropic.com/news/rare-dise…
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
New #preprint: an exciting and new aspect of #bioelectricity!
Most work on bioelectricity and electrophysiology focuses on events at the cell membrane. Here, we (@HamidSediqi18 , @cellbioelectric, et al.) tackle a new aspect of the electric dimension of cells: the nuclear membrane.
biorxiv.org/content/10.64898…
"Ionic Exposure History Shapes Inner Nuclear Membrane Voltage and Chromatin Texture Responses"
We created a new reagent for monitoring the voltage across the nuclear envelope, finding changes in chromatin and ordering effects (i.e., a kind of simple memory of past experiences) in its response to ionic stimuli. This is just the beginning - a new target for monitoring and interventions that I predict will have a lot of impact on nuclear events (chromatin state, gene expression, etc.) and thus cell behavior.
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
We recently obtained the highest-resolution 3D images of the human brain ever taken from outside the skull. This is the first look.
Introducing Aleph, a research lab building brain interfaces for the telepathic future. (1/n)
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Our new paper lead by @vedanglad w/@AToliasLab "Letting the neural code speak..." arxiv.org/abs/2605.12485
We show how to get *monkey* visual neurons to TELL us in *human* language what images make them fire. We do this is an automated verifiable way at scale! How?
1) Build a digital twin of monkey visual areas that can accurately map visual inputs to neural activity.
2) Perform in-silico experiments on this twin to find many complex images that make a model neuron fire.
3) Use a vision-language model to describe these complex images.
4) Verification: use a language-conditioned diffusion model to generate new images, and check they make the monkey digital twin neurons fire a lot.
To our knowledge, for the first time, we have a way to convert monkey vision to human language, and from *human* language to sample infinitely many images that make any given *monkey* visual neuron fire, all in an algorithmic fashion.
For more exciting details, see @vedanglad's excellent thread!
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Most neural nets are still based on the model of a neuron as proposed in the 1950's: u = activation(w·x + b)
In a new paper, researchers propose a more accurate model of a biological brain neuron and found that it has quite a few advantages, like needing less training data.
![Schematic neuron models. Left: standard neuron model in ANNs, following a simplistic abstraction from the neuroscience of the 1950s [1, 2] that assumed linear dendrites and an output nonlinearity. Right: proposed neuron model, based on a recent model of cortical cells [22]; notice how this new model extends the standard neuron model by considering internal nonlinearities σ (that represent dendritic processes), and these nonlinearities are affected in a dynamic way by the activity value zi (that represents the bAP going from the soma to the dendrites), itself depending on the inputs xj and the contributions zk from other neurons.](https://pbs.twimg.com/media/HJtlbTIWgAYoodY.jpg?name=small&format=webp)
ALT Schematic neuron models. Left: standard neuron model in ANNs, following a simplistic abstraction from the neuroscience of the 1950s [1, 2] that assumed linear dendrites and an output nonlinearity. Right: proposed neuron model, based on a recent model of cortical cells [22]; notice how this new model extends the standard neuron model by considering internal nonlinearities σ (that represent dendritic processes), and these nonlinearities are affected in a dynamic way by the activity value zi (that represents the bAP going from the soma to the dendrites), itself depending on the inputs xj and the contributions zk from other neurons.
we've already seen that biology models represent features in curved geometries — see our work on a fragmentomic signal for alzheimer's! our neural geometry agenda is bringing us closer to understanding models' natural ontologies
some of the most interesting artifacts in history
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Neural networks might speak English, but they think in shapes.
Understanding their rich *neural geometry* is key to understanding how they work – and to debugging and controlling them with precision.
Starting today, we’re releasing a series of posts on this research agenda. 🧵
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Parameter decomposition has just started working on LLMs. SAEcels in absolute shambles.
My team at @GoodfireAI has been cooking up a new way to do interpretability: decompose a language model’s weights, not its activations.
Our decomposition natively handles attention (!) and behaves less like a lookup table and more like a generalizing algorithm. (1/6)
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
This looks amazing. Rats composing long action sequences out of short ones. mPFC constructing the long sequence by Reusing primitive representations but composing overall progression. One of the most impressive things I have ever seen a rodent do.
biorxiv.org/content/10.64898…
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
How do recurrent networks decide what to spontaneously replay? Check out our new preprint!
w/@ClopathLab
biorxiv.org/content/10.64898…
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Research we co-authored on subliminal learning—how LLMs can pass on traits like preferences or misalignment through hidden signals in data—was published today in @Nature.
Read the paper: nature.com/articles/s41586-0…
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
I strongly suspect that Claude Mythos is a looped language model, as described in the paper "Scaling Latent Reasoning via Looped Language Models" from ByteDance
The authors of that paper called out graph search as one of the areas where looping provides a huge theoretical advantage over standard RLVR. And look at where Mythos blows out its competitors the most
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
Software horror: litellm PyPI supply chain attack.
Simple `pip install litellm` was enough to exfiltrate SSH keys, AWS/GCP/Azure creds, Kubernetes configs, git credentials, env vars (all your API keys), shell history, crypto wallets, SSL private keys, CI/CD secrets, database passwords.
LiteLLM itself has 97 million downloads per month which is already terrible, but much worse, the contagion spreads to any project that depends on litellm. For example, if you did `pip install dspy` (which depended on litellm>=1.64.0), you'd also be pwnd. Same for any other large project that depended on litellm.
Afaict the poisoned version was up for only less than ~1 hour. The attack had a bug which led to its discovery - Callum McMahon was using an MCP plugin inside Cursor that pulled in litellm as a transitive dependency. When litellm 1.82.8 installed, their machine ran out of RAM and crashed. So if the attacker didn't vibe code this attack it could have been undetected for many days or weeks.
Supply chain attacks like this are basically the scariest thing imaginable in modern software. Every time you install any depedency you could be pulling in a poisoned package anywhere deep inside its entire depedency tree. This is especially risky with large projects that might have lots and lots of dependencies. The credentials that do get stolen in each attack can then be used to take over more accounts and compromise more packages.
Classical software engineering would have you believe that dependencies are good (we're building pyramids from bricks), but imo this has to be re-evaluated, and it's why I've been so growingly averse to them, preferring to use LLMs to "yoink" functionality when it's simple enough and possible.
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
As always, very interesting work by @scott_linderman et al! They let the dynamical system itself evolve over trials, which allows modeling representational drift. Very interesting read for the neural manifold crowd as well
Stiefel Manifold Dynamical Systems for Tracking Representational Drift biorxiv.org/content/10.64898… #biorxiv_neursci
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
I am totally pumped about this new work. "Task-trained RNNs" are a powerful and influential framework in neuroscience, but have lacked a firm theoretical footing. This work provides one, and makes direct contact with the classical theory of random RNNs.
biorxiv.org/content/10.64898…
Prof. Donald Knuth opened his new paper with "Shock! Shock!"
Claude Opus 4.6 had just solved an open problem he'd been working on for weeks — a graph decomposition conjecture from The Art of Computer Programming.
He named the paper "Claude's Cycles."
31 explorations. ~1 hour. Knuth read the output, wrote the formal proof, and closed with: "It seems I'll have to revise my opinions about generative AI one of these days."
The man who wrote the bible of computer science just said that. In a paper named after an AI.
Paper: cs.stanford.edu/~knuth/paper…
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
It’s extremely good that Anthropic has not backed down, and it’s siginficant that OpenAI has taken a similar stance.
In the future, there will be much more challenging situations of this nature, and it will be critical for the relevant leaders to rise up to the occasion, for fierce competitors to put their differences aside. Good to see that happen today.
ℜ𝗒an (sigmoid.social/@SynapticSage) retweeted
A really dangerous situation. Too many submissions. Too many generated papers. Little responsibility.
1. In 2026, more than 24,000 submissions were made to the International Conference on Machine Learning (ICML). It’s TWO times more than in 2025. To fight it, the organizers now require researchers to pay $100 for every subsequent paper.
2. LLM adoption has increased researcher productivity by 90% (there’s a recent paper in Science).
3. The number of papers is becoming far too high. Submissions to arXiv have risen by 50% since 2022.
4. There are simply not enough reviewers. Plus, many scientists no longer want to invest precious time in it for free.
5. We can’t easily identify AI-made papers from the genuine ones.
__
Important words from Paul Ginsparg, a co-founder of arXiv:
“AI slop frequently can’t be discriminated just by looking at abstract, or even by just skimming full text. This makes it an “existential threat” to the system.”
Basically, we’re getting closer to the tipping point.
📍 Many professors blame the AI.
But the problem is likely elsewhere:
1. Without a sufficient number of papers, many PIs can’t get funded. They have to prove their credibility to reviewers. Their proposals have to rely on prior publications. In many countries, there are some informal (or even formal) expectations for how many papers a group with a certain size has to publish to survive (funding-wise).
2. Our students / postdocs need papers if they want to be hired in faculty roles. Yes, some departments hire people with few publications. But the majority still want to ensure their faculty can get funded. If funding is partly a function of papers, this is used in decision-making.
3. The number of papers is important if you want to get high-level awards. Many of them are not given because you published one paper (even if it’s great). They are given because you made a meaningful CONTRIBUTION to the field. How do you make it? Publish more papers.
4. Tenure promotions in many places take the number of your papers into account (often indirectly). Your tenure may get delayed if you don’t publish enough. Not everywhere, but for many mid- to low-ranked universities this story is more or less the same.
+ There are many more to mention.
📍My opinion:
Much of this is rooted in how funding is distributed.
There is a strong correlation between the requirements at a university and the funding acquisition criteria.
If funding were based ONLY on the quality of published papers, universities would hire people for the quality of their science. If funding agencies strongly discouraged publishing too many papers, universities wouldn’t expect numbers from faculty during promotions. And some supervisors wouldn’t pressure students and postdocs to publish unfinished studies and low-quality data.
Yes, we need good detectors of fake papers.
But we also need the right policies and better funding allocation criteria.

































