@TewheyLab

Identifying the precise genetic mechanisms influencing human complex traits and disease risk at the @JacksonLab 🧬🐭💻✨ (tweets from students and post docs)

 The Jackson Laboratory, ME
tewheylab.org/
Joined August 2022
  • Tweets56
  • Following84
  • Followers145
I know you thought it was just another Thursday but SURPRISE! The Tewhey Lab is officially on Twitter!!! 🥳 Watch this space for science, lab and other fun updates from @r_tewhey's lab ⬇️
Group picture of the Tewhey Lab in front of the JAX sign.

ALT Group picture of the Tewhey Lab in front of the JAX sign.

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Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti nature.com/articles/s41586-0… 1/7
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I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. nature.com/articles/s41586-0… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

Machine-guided design of cell-type-targeting cis-regulatory elements

Nature - A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.

nature.com
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Using #AI, a Broad/@jacksonlab /@YaleMed team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI @ReillyLikesIt
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Happy National Postdoc Appreciation Week to Tewhey Lab post-doc @takeshi_iwasaki!! 🥳🎉 Takeshi is studying regulatory variants in autoimmune disease and is actually this year’s @jacksonlab JAX scholar!!🏆🧬 #NPAW2024
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Yes Takeshi!!!! JAX Scholar and Tewhey Lab post doc @takeshi_iwasaki talks about his work in the lab ⬇️🧬
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Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays! biorxiv.org/content/10.1101/… See below for a 🧵. 1/n

Functional dissection of complex and molecular trait variants at single nucleotide resolution

Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics. The majority of these variants have individually weak effects and lie...

biorxiv.org
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This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/
Sager Gosai@SagerGosai10 Aug 2023
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n

Machine-guided design of synthetic cell type-specific cis-regulatory elements

Cis -regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing, and stimulus responses, which collectively define the thousands of unique cell types in...

biorxiv.org
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SO happy this is live! See @SagerGosai tweet explaining our amazing collab with @i_rodcast, @r_tewhey, @PardisSabeti! TLDR: Used AI to learn to 'read' the genome's regulatory code and 'write' new, synthetic functions. Evolution didn't create this neuronal enhancer, but it works!
Sager Gosai@SagerGosai10 Aug 2023
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n

Machine-guided design of synthetic cell type-specific cis-regulatory elements

Cis -regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing, and stimulus responses, which collectively define the thousands of unique cell types in...

biorxiv.org
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Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ @r_tewhey @TewheyLab
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I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n

Machine-guided design of synthetic cell type-specific cis-regulatory elements

Cis -regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing, and stimulus responses, which collectively define the thousands of unique cell types in...

biorxiv.org
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It’s official, the Twitter bio has been changed - ya girl’s a PhD candidate! 🥳 Grateful for all the support from my friends, family and committee! Super relieved to be done and even more ready for some of that Maine summer!! ☀️(Note: loading bar is not to scale…at all…)
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Getting emotional about friendship and an ice bucket on a Thursday. 🥲🧊
Steve Reilly@ReillyLikesIt13 Apr 2023
Replying to @ReillyLikesIt @r_tewhey @TewheyLab
the ice bucket, from corning, is truly an ELITE ice bucket. It's the Rolls Royce of ice buckets. The kind you get an unhealthy obsession with during your post doc, and won't buy for your own lab. Until your amazing friend buys one for you :)
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Congratulations!! Kousuke's talk at @IMGC2023_sec was based on his paper on genetic variants of regulatory elements in autoimmune disease. Read Kousuke's BACH2 paper here: nature.com/articles/s41588-0…

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element...

Nature Genetics - Integrating methods that assess allele-specific regulatory activity and chromatin accessibility in T cells identifies putative causal variants for five autoimmune diseases.

nature.com
Kousuke MOURI@kousuke_mouri3 Apr 2023
Thank you so much @IMGC2023_sec for selecting my talk as an outstanding presentation. It is a great honor!
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Congratulations to postdoc @kousuke_mouri for winning Outstanding Oral Presentation at @IMGC2023_sec 🧬 It's just BACH2 back wins for Kousuke!! 🥳
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The Tewhey Lab can confirm that the Reilly lab has great science AND great holiday cards!!
Steve Reilly@ReillyLikesIt9 Feb 2023
We're expanding! post-doc and post-grad positions available! YOU: into human evolution, deciphering regulatory variation, deep-learning, and/or developing functional characterization methods... + a lab that makes mildly over the top holiday cards. reilly-lab.com/news/new-posi…
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Congratulations @r_tewhey on a great promotion seminar for Associate Professor @jacksonlab 🥳🧬🐭 Ryan's talk was titled "Defining the genetic basis of complex traits and disease through the (de)coding of regulatory syntax". Learn more about our lab at tewheylab.org/
Ryan Tewhey stands at a podium in front of his title slide for his promotion seminar.

ALT Ryan Tewhey stands at a podium in front of his title slide for his promotion seminar.

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REST assured - this is a cool paper :) Read now at cell.com/cell-genomics/fullt…
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JAX wrote a nice article outlining our paper! Thank you! jax.org/news-and-insights/20…
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Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay dlvr.it/SfVX1j
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