Identifying the precise genetic mechanisms influencing human complex traits and disease risk at the @JacksonLab 🧬🐭💻✨ (tweets from students and post docs)
The Jackson Laboratory, ME
Joined August 2022
- Tweets56
- Following84
- Followers145
- Likes56
Tewhey Lab retweeted
Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti nature.com/articles/s41586-0… 1/7
Tewhey Lab retweeted
I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. nature.com/articles/s41586-0… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9
Tewhey Lab retweeted
Using #AI, a Broad/@jacksonlab /@YaleMed team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI @ReillyLikesIt
Tewhey Lab retweeted
Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays!
biorxiv.org/content/10.1101/…
See below for a 🧵. 1/n
Tewhey Lab retweeted
This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n
Tewhey Lab retweeted
SO happy this is live! See @SagerGosai tweet explaining our amazing collab with @i_rodcast, @r_tewhey, @PardisSabeti!
TLDR: Used AI to learn to 'read' the genome's regulatory code and 'write' new, synthetic functions. Evolution didn't create this neuronal enhancer, but it works!
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n
Tewhey Lab retweeted
Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ @r_tewhey @TewheyLab
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Tewhey Lab retweeted
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.1101/… 1/n
Tewhey Lab retweeted
It’s official, the Twitter bio has been changed - ya girl’s a PhD candidate! 🥳 Grateful for all the support from my friends, family and committee! Super relieved to be done and even more ready for some of that Maine summer!! ☀️(Note: loading bar is not to scale…at all…)
Tewhey Lab retweeted
JAX wrote a nice article outlining our paper! Thank you!
jax.org/news-and-insights/20…
Tewhey Lab retweeted
Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay dlvr.it/SfVX1j
Tewhey Lab retweeted
Our latest paper led by the amazing @kousuke_mouri is now out in @CellGenomics.
We reconfigured MPRA to perform a genome-wide screen of REST binding sites and the variation residing at these sites. 🧪+🧬+🔇=🪩🎉
Read the thread below for details 👇
Our paper on functional characterization of whole genome RE1 silencer is out now @CellGenomics ! cell.com/cell-genomics/fullt… 1/8
Tewhey Lab retweeted
Our paper on functional characterization of whole genome RE1 silencer is out now @CellGenomics ! cell.com/cell-genomics/fullt… 1/8
Tewhey Lab retweeted
Yesterday our very first graduate student successfully defended her thesis. Congratulations Dr. Arora 🥂🎓(@UmaArora16) you have been a great scientist, mentor and friend to everybody in the lab. Your positive attitude and light will be missed.
Tewhey Lab retweeted
Thank you, Ryan!! It has been absolutely fantastic to get to work with you on this - and folks, Ryan’s lab at Jax laboratories is hiring postdocs!! An amazing chance to work with a brilliant scientist and mentor!
Tewhey Lab retweeted
🎉🧬This has been a fun collaboration with the brilliant @LaylaSiraj and team!
Shameless plug... We have open postdoc positions in the @TewheyLab at @jacksonlab applying MPRA & developing new methods to traverse variant-to-phenotype in multiple human diseases. DM for details 🧪
See the thread below for a great recap of our work with @r_tewhey , @ReillyLikesIt , @julirsch , and @hilaryfinucane ! Dr. Samocha - gene was ESS2, and yes, emVars are variants demonstrating allelic skew in MPRA
Tewhey Lab retweeted
I am incredibly thankful for the mentorship and guidance of @julirsch , @r_tewhey , @ReillyLikesIt , and of course my PIs @hilaryfinucane and @eric_lander . Stay tuned for our final work coming in a couple of months!
Extremely honored to be named one of the three pre-doctoral winners of the Charles J Epstein Award for Excellence in Human Genetics along with @ffstaeger and Marianne Lemée at #ASHG2022 @GeneticsSociety! 1/2
Tewhey Lab retweeted
Excellent session on Massively Parallel Variant Characterization with nice talks from @angelamyu (splicing) @LaylaSiraj (regulation) @MoezDawood (PALB2 missense) #ASHG22 #VUS
Tewhey Lab retweeted
Super excited for @LaylaSiraj ‘s talk soon at #ASHG22. Absolutely herculean effort to quantify the functional effects of 234,448 likely causal regulatory variants underlying complex human traits from #gtex and #ukbb. Amazing collab between @TewheyLab, Fincunae lab, and us.
Tewhey Lab retweeted
Trying to get the official Tewhey lab twitter to 50 followers by the end of the day so go follow @TewheyLab asap!!! :’) – at Maine, USA