Synthetic biologist engineering mitochondria, RNA and new gene editing systems. NHMRC Investigator and Professor @CurtinUni @CurtinMRI and @TheKids_AU
Perth, Western Australia
Joined November 2017
- Tweets117
- Following854
- Followers1K
- Likes1.9K
The discovery of CRYAB as the binding partner of TANGO2 highlights the importance of intermediate filaments in metabolism and mitochondrial function and reveals the molecular basis of TANGO2 deficiency disorder (TDD)
nature.com/articles/s41467-0…
#metabolism
#mitochondria
@NatureComms
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia?
Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable
staff.curtin.edu.au/explore-…
Destroyer turned protector - FASTKD4 uses it’s Vsr nuclease-like structure to protect the polyadenylated tail of the mitochondrial MT-ND3 mRNA
academic.oup.com/nar/article…
#RNA
#mitochondria
#mtDNA
Better CRISPR base editors!
More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases.
@ACSSynBio
pubs.acs.org/doi/10.1021/acs…
Organelles within mammalian cells are surprisingly interconnected, and lipids play a critical role
Check out: Interorganelle phospholipid communication, a house not so divided @Trends_Endo_Met to see more
cell.com/trends/endocrinolog…
#metabolism
#mitochondria
#lipids
#Golgi
#ER
Illuminating mitochondrial translation through mouse models
@hmg_journal
academic.oup.com/hmg/article…
#mitochondria
#mtDNA
High-fidelity Cas9 variants that prevent off-target cleavage typically reduce on-target activity. Adding TurboCas9 mutations to these enzymes can improve activity while maintaining off-target fidelity. @CellRepMethods
cell.com/cell-reports-method…
“I am a part of all that I have met” – Ulysses; Alfred Tennyson
CRISPR screening, volumetric EM and multi-omics reveal the highly connected nature of organelles.
Defects in peroxisomes, Golgi and the ER converge on mitochondria via the lipidome.
nature.com/articles/s41556-0…
Expression of the mitochondrial genome in cells without nuclei.
Impaired mitochondrial RNA processing, modification or translation prevents platelet aggregation and leads to thrombocytopenia and excessive bleeding.
cell.com/cell-reports/fullte…
#mitochondria #platelets
A fantastic @ANZSCDB meeting in WA!
Thanks so much to our fantastic plenary speakers @jdmintern, @molregulation and @LabParton, local legends, and our sponsors @CHIRI_curtin, @ARC_CoESB and @PerkinsComms for making it such a great day!
Mitochondria have their own genetic code, breaking the standard rules of protein translation.
Combining ribosome profiling and cryo-EM reveals how an unusual release factor protein can replace a tRNA to subvert the standard genetic code.
@ScienceMagazine
science.org/doi/10.1126/scie…
