BRCA tumor suppression network | DNA damage repair | Ubiquitination
UT Health at San Antonio
Joined May 2021
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Zhao Lab retweeted
Check out our web tool to see interactive networks of DSB repair genes, browse your gene of interest for its contribution to DSB repair profiles and analyze functional relationships based on similarities in repair patterns
repairome.bioinfo.cnio.es
Enjoy!!!
Zhao Lab retweeted
Earlier this year, I learned I have a pathogenic variant in BRCA2, which gives me a very high lifetime risk of breast cancer (55-69%), as well as an increased risk of ovarian cancer (12-29%) and pancreatic cancer (5-10%).
🧵1/ …
Zhao Lab retweeted
Online Now: PALB2 and 53BP1 govern post-resection homologous recombination DNA repair dlvr.it/TMD4rW
Zhao Lab retweeted
Join us in beautiful Ventura for the 2025 GRC meeting, Mammalian DNA Repair: Fundamental Mechanisms to Human Biology grc.org/mammalian-dna-repair……… Great program, including keynotes from David Pellman and Maria Jasin. We will be selecting talks and poster slots soon. Apply now!
Zhao Lab retweeted
Assistant and Associate Professor positions available at UPENN's Basser Center for BRCA . Great opportunity to be part of an amazing scientific environment.
Assistant Level: apply.interfolio.com/155257
Associate Level : apply.interfolio.com/155258
Zhao Lab retweeted
I love this fundamental discovery science success story! Curiosity driven research birthed a new era of molecular medicine - congratulations and well deserved Drs. Ambros and Ruvkun! We need discovery and curiosity to remain a foundation of science.
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Zhao Lab retweeted
#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. bit.ly/3MQjHIr @LaskerFDN
Zhao Lab retweeted
Nature research paper: Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection go.nature.com/3zgF16U
Zhao Lab retweeted
Nature research paper: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination go.nature.com/3ZkCJhG
Zhao Lab retweeted
When overseeing grant review applications, one particularly grumpy reviewer pointed out why we should care about a mechanism when we know the approach works in the clinics. Exactly, why bother understanding how the engine works when the car still moves—until it doesn’t.
Thank you so much for promoting our work from V foundation. linkedin.com/posts/susanna-f…
Really excited to share this work led by Yuxin Huang and Wenjing Li. It reveals novel DNA binding activities located in HDOB1 of BRCA2, but it has to be “shut off” by DSS1 for proper BRCA2 activity. rdcu.be/dRaar
Importantly, this regulation is critical for BRCA2 to promote homologous recombination, stabilize replication fork, and prevent R-loop accumulation.
Zhao Lab retweeted
One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si=hyCJ…
Zhao Lab retweeted
The Cortez lab (lab.vanderbilt.edu/cortez-la…) is looking for new postdocs or senior scientists. If you are interested in genome stability, replication, DNA repair, or DNA damage responses please send me an email.
Zhao Lab retweeted
New work from the @leunglaboratory! @UTHealthSA @UTHSAResearch rdcu.be/dJzfA Evolved histone tail regulates 53BP1 recruitment at damaged chromatin in @NatureComms