Epidemiologist Postdoc @Penn with @damrauer PhD & MPH @karolinskainst | BM @WuHanUniv He/him/his. Views are my own.

Philly, PA
Joined February 2017
Congrats to Jonas! My wonderful mentor all the time!
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Excited to share that our paper is out in Circulation! Using data from the MVP, we conducted a large-scale epigenome-wide association study of abdominal aortic aneurysm and uncovered a wealth of epigenetic signals that may help shape how we understand this disease.
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Thanks to all coauthors, in particular my supervisor @damrauer @PennMedicine @PennCVI @PennCVFellows @karolinskainst
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Exited to share our GWAS study of #pancreatic cancer in @GenomeMedicine ! Thanks to all coauthors! @LarssonSC Full text link: link.springer.com/10.1186/s1…
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Shuai Yuan 袁帅 retweeted
Happy to see our paper on #MASLD and peripheral artery disease published in @JInternMed now. Kudos to [1au] @Yuan_AS @Penn for an incredible work and collaborators @damrauer @VujkovicM and collaborators at @karolinskainst and Basel university!
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Shuai Yuan 袁帅 retweeted
Large-scale human biobanks are one of the best investments for unlocking key insights about human health and disease. Our Future Health is the largest such study currently recruiting with >2.5M people already enrolled since 2022 and a goal of 5M by 2030!
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GLP1R R131Q enhances GLP-1RA stimulated insulin secretion, preserves β cell function, and improves treatment response, supporting further investigation as a candidate pharmacogenetic marker. Read here ➡️ doi.org/10.2337/dc26-0662 @AmDiabetesAssn @ADA_DiabetesPro @ADA_Pubs
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Shuai Yuan 袁帅 retweeted
In nationwide 🇸🇪 study of 14,801 patients with fatty liver (MASLD), we saw a +54% ⬆️ increased risk of peripheral arterial disease. Risk generally increased with histologic severity. Kudos to [1au] @Yuan_AS at @Penn and co-authors 🙏 @damrauer @jiangwei_sun @karolinskainst et al
New Research Letter! Histologic metabolic dysfunction–associated steatotic liver disease severity associated with a graded increase in peripheral artery disease risk. ➡️ #MASLD affects approximately 30% of adults 🔗doi.org/10.1111/joim.70141 #liverdisease
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Shuai Yuan 袁帅 retweeted
➡️ Postdoc position open in my research group ➡️ Liver epidemiology @karolinskainst Last application date: 3 August. Welcome with your application! #epitwitter #hepatology #liverdisease #liverhealth
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I’m truly honored to be selected as an Early Career Editor at @atvbahajournals. This is a great opportunity to contribute from the journal side and deepen my engagement with the publication process. I’m excited to get started and looking forward to the work ahead!
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Shuai Yuan 袁帅 retweeted
A successful hunt of human genome variants identifying some (with MR) that provide causal evidence that BMI affects microbe composition @NatureGenet nature.com/articles/s41588-0…
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Shuai Yuan 袁帅 retweeted
Findings from a recent study 📄 suggests that Lp(a) lowering may offer therapeutic benefit for AAA management, independent of conventional risk factor modification, including ApoB reduction. Learn more➡️ spr.ly/6019CfvhS @Yuan_AS @damrauer #AorticAneurysm #CVDRisk
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Shuai Yuan 袁帅 retweeted
📣My lab at Massachusetts General Hospital and Broad Institute is hiring a postdoctoral fellow: massgeneralbrigham.wd1.mywor… If you have a strong quantitative background & are interested in using large-scale multi-omics🧬to study cardiovascular disease and aging, I hope you apply!
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This study identified significant differences in DNA methylation patterns between healthy controls vs. patients with claudication and PAD and by self reported race. @JonathanBrownMD @AlexSullivan_MD @joshuabeckmanmd @Yuan_AS @damrauer ahajournals.org/doi/full/10.…
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I am deeply honored to be selected as a finalist for the Jay D. Coffman Early Career Investigator Award Competition by the AHA Council on Peripheral Vascular Disease. I look forward to this exciting scientific gathering in New Orleans, Louisiana, November 7–10. @American_Heart
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Shuai Yuan 袁帅 retweeted
A combination of animal studies, data from a clinical trial, and insights from an observational cohort suggest that, in individuals with MASH, semaglutide improves liver histology by reverting patient proteomes to better mimic the proteome of individuals without the disease. nature.com/articles/s41591-0…
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