Imad Bagh retweeted
Disappointing news. Fact is we will not see this drug for several years. But since these were extremely high risk folks, it seems like there should at least be a signal or trend of MACE reduction with pelacarsen drastically lowering Lp(a) that would at least make continuing the trial unethical. Might it be that high intensity statin alone without Lp(a) reduction is the best that can be offered? Would statin plus a PCSK9i (and its powerful ability to reduce apoB have been a better choice? At least that is an off-label choice at present
News from @Novartis
Readout for HORIZON Ph3 cardiovascular outcomes trial testing pelacarsen - ASO targeting Lipoprotein(a)
now *2026*
(earlier guidance had been 2025)
An event driven trial and event rate seems lower than initially projected
novartis.com/sites/novartis_…
Imad Bagh retweeted
Repost if you agree (and plz comment): The time is NOW for vascular medicine @SVM_tweets @JoshuaBeckmanMD @RKolluriMD @herbaronowMD @GenoMerli @Angiologist @bgray71357 journals.sagepub.com/doi/10.…
Imad Bagh retweeted
More highlights from this weekend - reuniting with friends and mentors 📸
#ACC23 #ACCFIT @ACCinTouch @MountSinaiHeart @IcahnMountSinai @NYCHealthSystem
So proud of my @MSHCardsCT fellows for all their contributions this weekend!
#ACC2023 #WCCardio #cardiotwitter #cardiologistsintraining
Imad Bagh retweeted
This prematurely terminated CANARY Trial of patients with intermediate-high–risk PE was hypothesis-generating for improvement in some efficacy outcomes and acceptable rate of major bleeding for catheter-directed lysis compared with anticoagulation
Here: jamanetwork.com/journals/jam…
Imad Bagh retweeted
Horrendous hemorrhagic complications with OAC in ESRD with AFib : “The 1-year rates for major or clinically relevant non-major bleeding were 32% and 26% in apixaban and warfarin groups, respectively”. Worse mortality for apixaban as well (26% vs 18%) ahajournals.org/doi/10.1161/….
Imad Bagh retweeted
Give a talk on tips for getting a paper published for early career docs. I had fun putting it together with my own reflections as a jr. author, sr. author, peer reviewer, and editor. I thought I would share a 🧵 @svm_tweets #ACCFIT #SVMNextGen #publishing
Imad Bagh retweeted
Coffee lovers will love this new report ;-)
academic.oup.com/eurjpc/adva…
@escardio @BakerResearchAu @uk_biobank
☕️☕️☕️
Imad Bagh retweeted
🎓Congrats to our graduating fellows!
Thank you for your endless support, teaching, and friendship - not to mention your time at the COVID epicenter during the height of the pandemic.
The future of cardiology is bright 😎
@bagh_imad @M_CagliostroMD @emanrashed01 @dsternheim1
Imad Bagh retweeted
What’s actually happening in thoracic outlet syndrome ⬇️
Via @paulgamboad
#MedTwitter
Imad Bagh retweeted
Good news for coffee drinkers ☕️☕️
Debunking the dogma that coffee increases the risk of heart rhythm disturbances, from >386,000 people, 4.5 year follow-up, including putative genomic risk variants
@JAMAInternalMed jamanetwork.com/journals/jam… @uk_biobank
Imad Bagh retweeted
In patients hospitalised with #COVID19 & elevated D-dimer, in-hospital therapeutic anticoagulation with rivaroxaban or enoxaparin followed by riva to day 30 did not improve clinical outcomes & increased bleeding compared with prophylactic anticoagulation thelancet.com/journals/lance…
Understanding Academic Medical Centers: Simone’s Maxims | Clinical Cancer Research clincancerres.aacrjournals.o…
Imad Bagh retweeted
Another variation of this theme is assessing AS in A Fib with different cycle lengths. #Nkomo @MayoClinicCV have the data that a single highest LVOT and AV velocities can reflect the severity of AS , better than averaging 3 or 5 cycles which is time consuming. See figure below.
@RowseMD Post PVC LV contraction is potentiated + increased LVEDV, increased SV, result = increased gradient & PP in AS & decreased PP in HCM. May be LV in AS has novel response under GA in OR?@adnanalkhouli @JaeKOh2 @RickNishimura @fuadfehmi @mahali87
Individual and community-level risk for COVID-19 mortality in the United States | Nature Medicine nature.com/articles/s41591-0…
Imad Bagh retweeted
As if this graph was not bad enough, new data to layer on: administrative costs. In 2017, for US it was 34.2% of all health expenditures; for Canada it was 17.0%. Per capita 4.5X
annals.org/aim/fullarticle/2… @AnnalsofIM by @swoolhandler @terrycampbell01
Graph: economist.com/graphic-detail…
