
fixing healthcare @getlunabill
San Francisco, CA
Joined June 2024
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Soheil Parry retweeted
There are a few things that Manidis and Roberts get exactly right.
Small firms will achieve outcomes completely disproportionate to their headcount. These “raiding party” sized groups will outperform at a shocking scale. The countries that rose through the outsourcing of backoffices will fall as those jobs evaporate into the algo. Call center countries reduced to scam hovels.
Scarce, permanent assets will be the holy grail of the AI economy. Assets that cannot be vibe-coded, that will grow under AI dominance rather than shrink. These will often be "rails", physical sites, or “nation-state” assets like a power grid, a copper mine, or a strategic landmass.
“The fourth settlement is one sympathetic to great men and leaves little room for labor as you know it.” This is one of the best lines in the piece and a nice key to the next few decades. If you told people two hundred years ago that labor would be abolished, they would be stoked. Today they whine, “don’t take my toil, let me listen to a pod while I type.”
Inevitably, some of the predictions in the piece will miss. Where this is the case, I think it will be a result of the authors' sheer proximity to the center. Too near to the fire, lobotomized by the Flow. NYC and SF crowds are certain that their world is the only one. A perennial solipsism dominates both bubbles, a gravitational pull that Manidis and Roberts (and the friendly ghost of Leopold Aschenbrenner) are not immune to. The authors argue that all capital will be made subservient to the Line. The Line must go up. AI must continue its march, even irrationally, to prevent massive capital destruction of all that has come before.
But outside of the epicenters, the people have no allegiance to the Line. My brother in Idaho has no allegiance to the Line. Your friend who bartends in Orlando has no allegiance to the Line. For the Leopolds in SF and the FO boys on wall street, it may be their only reality, their existence and work and net worth but the everyman has not corrupted his mind with expectations of winning the final gluttonous end times tech lottery. He has no allegiance to the Line.
Manidis and Roberts argue that the populace will be tied via pensions, equities, and trump accounts to the success of AI, but I don’t see that that coupling has truly taken place yet.
Downstream of this, I still don't see the US nationalizing the AI labs. The labs tried hard but the critical moment has come and gone. The administration has already decided that it is intolerable to be equity partners with Altman or Dario. Some will live and some will die. As long as boomers have a blood in their veins, they'll cling to their free-markets while the groypers and DSA kids would rather see recession than the tech oligarchs and bankers enriched in victory.
Where does this take us? Coming years will be dominated by powerful firms in the private sector and great men, value will accrue to assets that are scarce and durable, companies will act more like countries. Will and Joe are going to make some killer, generational investments during this era.
Thanks to Will and Joe for writing and giving people something think about and to shoot at. I saw some folks complain that the piece is too grim or apocalyptic. I blame the popularization of end times biblical language by the one paypal co-founder. The future that the bible actually predicts is much more interesting. One of the inevitable victory of christendom–––the past and future conquest of Christ over all. Shaping the victorious timeline is our ultimate duty and opportunity.
The benefits of abundant intelligence will accrue far outside of San Fransisco.
Spent the last year writing about capital, sovereignty, and the coming reordering of economic power.
THE COMMANDING HEIGHTS
Commanding-Heights.com
1. humanity’s achilles heel is the biological reset
2. do u think AI will contract @SpaceX to mine solar system?
2.1) what are the contract terms? accelerating @neuralink ?
One reason I am sanguine about the technological singularity is that I have seen it coming for over 50 years. In 1975, when I was 17, I wrote:
"Before man can most effectively aid his problem solving machinery, he must first understand it. At present, his understanding is very poor. However, when the breakthrough in understanding the brain occurs, improvement will come very fast and in an exponential increase. Once man has created an intelligence greater than his own, that intelligence should be able to create an intelligence greater than itself, as man whose intelligence is less than its was able to create its intelligence. Thus, the level of intelligence will shoot up with incredible rapidity, probably within the space of years. Within a few years of a breakthrough, which may occur any time now, man will either have been left behind by a superior intelligence of his own making, which he can no longer understand, or he will have become that intelligence and will no longer be like anything imaginable today."
wtf, the whole time i thought @VitalikButerin was gay
i was ashamed of myself when i realized life was a costume party, and i attended with my real face
prolly kafka
200 likes? we’re gonna need a few million if im supposed to cover their salary with my x revenue
Replying to @bitcoinbasha
Hot take, but sharing a photo of someone’s work without their consent is creepy.
Someone could lose their income just so you can get 200 likes.
If you look closely enough, breakthroughs in everything are accelerating exponentially.
An exponential always starts off looking small.
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
canadian @hootsuite spent $60m acquiring a chatbot startup few months before chatgpt launched.
same ppl are the 90% of executives who report no productivity impact from AI.
i’m short incumbents even with their ‘AI incorporating strategies’
i see this in healthcare everyday lol
i hope the pace of AI fills ppl with more wonder than surprise.
i find it hard to agree with @harari_yuval on many things, but his recent analogy stayed with me.
cows know humans exist, but cannot comprehend the economic systems and financial engineering that determine their lives. AI may soon advance beyond human comprehension in much the same way.
i think we should be building governing institutions not to safeguard against AI, but with a vision to serve as a liaison between AI and humanity.
maybe AI eventually takes care of our needs while pursuing goals beyond our understanding.
Announcing three major scientific discoveries, one each in mathematics (harmonic analysis), computer science (complexity theory), and physics (quantum field theory).
AI starting to help us improve our understanding of the universe! openai.com/index/building-sc…
canada has problems, but the US is an outlier, not the baseline.
having US next door is a massive advantage and disadvantage. like roughly 1 in 4 STEM grads from waterloo, ut & ubc move to the US. plenty of reasons we already know of.
it is not that we are “lacking ambition”, some of that ambition has a US address now.
i also find the canada vs US scoreboard unhealthy. canada helps fund the education, the US recruits the talent. we both benefit from this connection, and are not two separate teams.
we can definitely ask why people leave and what would make them stay. but i’m long on this relationship. making it work better for both countries will do more for canada than constantly asking why we aren’t america.
Spent the last 2 weeks in Canada, and it's immediately clear why America will keep its competitive advantage forever.
Don't get me wrong, I love Canada! It's beautiful out here, and the people themselves are also lovely.
But! There is a serious lack of ambition, and an enormous amount of averseness to risk in a way that is not really fixable imo
this would be funny if we hadn’t spent years seeing what drones can do in ukraine.
“highest security” and it made it to his cell window? we’re lucky this delivery was nuggets. what is Canada doing to stop the next one?
nursing home PE firms seeing a surge in corporate middle management job postings on linkedin
Strong link between frequent daytime napping and an elevated risk of developing dementia, according to new research from the Johns Hopkins Bloomberg School of Public Health.
Readers added context they thought people might want to know
The study was about unintended napping, and in fact whether the naps were intended or unintended was a key factor examined. In addition, the researchers are not claiming causation. publichealth.jhu.edu/2026/frequent-…
. @davidgraeber wrote an entire book called bullshit jobs.
i’d bet 30% of jobs at firms like accenture qualify, and half the workday is spent on pointless activities.
but sure, a $29/month claude limit is the real sign of AI doom.
New: Accenture has told employees it will only fund $29 per month of Claude use. Meaning that employees who often spend as much as $1,000 a month are now scrambling to find ways to keep access to the tool. A sign of the continuing crack down of AI 404media.co/accenture-tells-…



























