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Goodmorning to you good people (not you Deepinder). Now that India has entered the commercial era of "scienceploitation", I would like to educate and inform the people on this topic, using one of Temple device's claims as an example. This is long, but stay with me, you will really benefit. But first, what is Scienceploitation? It is a marketing and communication tactic where brands, influencers, or media outlets borrow or manipulate language from legitimate, emerging areas of science (such as stem cell research, the microbiome, or epigenetics) to promote unproven health, wellness, or beauty products and services. The term was coined by @CaulfieldTim (I am honored to have known him and written an editorial with him in the BMJ), a professor of health law and policy at the University of Alberta. Temple Device is your first boss battle against scienceploitation. Let me explain this using their own biggest claim - ENTROPY. Temple claims it measures Entropy. What is entropy? In lay terms, entropy is a measure of how spread out, mixed up, or disorganized things naturally become over time. In human health, entropy can be a measure of disorder, wear and tear, and loss of organization in your body's cells, tissues, and organ systems. Low Entropy = High Health (Order): A young, healthy body is in a state of low entropy. Your cells are communicating well, your DNA is intact, your proteins are folded properly, and your heartbeats have a smooth, adaptable rhythm. High Entropy = Disease or Aging (Disorder): As entropy increases, biological "mess" builds up. Damaged DNA accumulates, proteins misfold, cells stop working right, and communication breaks down. Aging is essentially a slow, natural rise in entropy. While conditions like cancer (uncontrolled, chaotic cell growth), neurodegeneration (like Alzheimer’s protein tangles), and metabolic dysfunction (like uncontrolled blood sugar) represent spikes of high entropy in specific parts of the body. Note that - aging is a normal anatomical and physiological process, it is not a disease. Now you know how complex this term is? Well, this is what Deepinder Goyal's Temple device claims to measure. A device can produce a number without proving that the number means what its advertising says. That is the central problem with Temple’s “Entropy.” “Entropy” has different scientific meanings. In physics, it concerns energy transformations. In heartbeat or brainwave analysis, it describes how irregular or unpredictable a signal is. Measuring one does not mean you have measured the other, or someone’s overall health. Yes, wearable recordings can be used to calculate signal entropy. A Polar H10 chest strap, for example, records heartbeat intervals that suitable software can analyse. GE’s clinical Entropy monitor analyses electrical signals from the forehead to help assess anaesthesia. Neither tells you how much “disorder” your body contains or how long you will live. Temple’s published research describes an optical sensor that shines light into skin and detects changes associated with blood flow. That can provide useful physiological information of flow and perfusion only there or at the heart level, but not the brain or other systems. And detecting blood-related signals does not automatically measure whole-body heat loss, metabolism or thermodynamic entropy. Those claims are wild. Extraordinary claims require extraordinary evidence. Researchers have estimated human thermodynamic entropy production. The experiment cited by Temple used a whole-body calorimeter, measurements of breathing gases and mathematical modelling. It did not demonstrate that a small optical sensor at the temple could do the same job. Misrepresenting and misinterpreting genuine research and extrapolating that to a new device does not establish that Temple performs the measurement described in that research - this is classical Scienceploitation. It Is "sciencey" word salads. Non-medical people will fall for this sort of gimmicks. Temple also claims that lower resting “Entropy” means better health. That is not an established universal rule. Even the theoretical paper it cites discusses the importance of maintaining adequate entropy production and increasing it when needed—not simply driving the resting value ever lower. A lower number needs a proven health meaning before it becomes a health goal. Deepinder's Science Team has to prove this first, before they let their "machine" measure it - if it really can. A reading that changes with exercise, meals, stress or temperature may be responding to real physiology. But that does not prove it measures immune health, digestion, reproductive function or recovery. Responding to many things is not the same as understanding or measuring all those things. Temple lists (their own) preliminary studies of heart rate and brain-circulation-related signals. Those studies do not establish the advertised health meanings of “Resting Entropy,” “Entropy Max” or “Span.” These cannot be measured using currently available wearable tech, including Temple. Combining readings into a new score does not remove the need to validate that score, or if the score is really meaningful to start with. Pretty much like Homeopathy. So much stuff, no content or context. Highly advanced wearable science is not impossible. The problem is presenting an unvalidated interpretation as an established fact about your body. Calling a product “wellness” does not make its scientific claims true. Temple device is the commercial, expensive example of consumer scienceploitation. The website needs to be updated with medical and health truths rather than magical thinking and delusions of so-called founder and his science team. Deepinder's Temple device is very much like Baba Ramdev's Coronil. Only one difference. Former is scienceploitation, latter is pseudoscience and both are harmful in their own ways. Learn to identify a scam and fraud when you see one.

This is in very bad faith Yuvraj. You are a good cricketer, you are a strong human, a cancer survivor. But you are an absolute health and science illiterate. People like you and your business of bad science deeply damages science literacy and public health in our society. It is a pathetic. You can be powerful allies for cancer patients and oncology societies and use your voice to educate people on evidence-based preventative care and direct cancer patients towards science-based care for improved survival outcomes. But instead, you chose to team up with unethical businessmen - some with long degrees, lengthy certifications and in high positions without any functioning brain cell - and among them, one of the worst "health" influencers on the internet right now, the so-called cancer surgeon Arpit Bansal who is a pseudoscience sympathizer, an Ayurveda apologist and quite similar to Luke Coutinho, but with actual medical degrees wasted. Know this first: Cancer patients who use alternative medicine die sooner, study finds - nbcnews.com/health/health-ne… Now coming to your product - P32 Among the 32 listed ingredients with 35+ distinct compounds in them, 13 carry documented risks of organ toxicity, mineral toxicity, capable of causing/promoting atherosclerosis inducing toxin generation, and with high rates of toxic environmental contamination. Four ingredients - Ashwagandha, Bacopa, Curcumin and Boswellia are among the most frequently implicated botanicals in liver injury in LiverTox registries. When they come together, it is going to be disastrous. medpagetoday.com/gastroenter… - The person who designed this complex formulation is really a clown. Nearly all 30 active ingredients in this 32-ingredient supplement lack solid scientific proof for the health benefits promised on the label. First, the company's own chart admits that eight ingredients have no gold-standard human trials behind them - two are just inactive fillers, and six rely on weaker data or are added only for safety, yet are still marketed as multi-organ boosters. At least 11 ingredients are "fairy-dusted," meaning the sachet contains only a tiny fraction of the daily dose actually proven to work in human studies. High-level clinical and translational evidence demonstrates that several components in this sachet can actually increase cancer risk or accelerate tumor progression in healthy adults: Vitamin E (prostate cancer), combined folic acid+B12 (lung and colon cancer) and NAC, Vit E, Vit C, Astaxanthin (increase risk of cancer spread). See this paper: Supplement Use and Increased Risks of Cancer: Unveiling the Other Side of the Coin - pmc.ncbi.nlm.nih.gov/article… Finally, the product stretches basic science by assuming that because a nutrient deficiency harms certain organs, taking extra amounts will supercharge those same organs in healthy adults who already get enough nutrients. Your product is absolute BS just like the whole of herbal and dietary supplement industry is. Have some shame selling this nonsense to public and people with cancer. I hope nobody accepts your stupid invite.

HELLO! I HAVE AN ANNOUNCEMENT THAT BENEFITS YOU! WE NEED YOUR SUPPORT. We are back. And this time, we are taking on arguably the biggest wellness hack that people spend money on. The NEW Citizens Project will now look at a massive list of Probiotics for their quality claims. People consume probiotics for a host of things. Gut health, protection against alcohol use, brain improvement, improving digestive symptoms, exercise recovery and even sleep! Despite generating over $75 billion in annual sales (and heading toward $115 billion by 2030), most store-bought probiotics suffer from poor quality control because they are regulated as food supplements rather than medicines. Independent lab tests regularly reveal that what is on the label is not inside the bottle: products frequently contain dead bacteria, far lower doses than advertised, missing bacterial types, or unlisted contaminants. Even when the microbes are alive on the shelf, poorly made capsules often fail to protect them, meaning stomach acid destroys the bacteria before they ever reach your gut. These widespread failures show an urgent need for strict regulation and mandatory independent testing before products reach consumers. For a generally healthy person, over-the-counter probiotics rarely deliver real value for money or live up to their bold marketing promises. Good bacteria are not a one-size-fits-all cure; specific microbes only help specific illnesses, and in a healthy gut, supplement bacteria usually pass right through the body without sticking around. Unless a doctor recommends a clinically proven product for a specific medical issue, buying daily general probiotics is largely an expensive waste of money. Are you wasting money of the hyper rated probiotic supplements? Are you really getting what you spend money for? The Citizens Probiotics Project will look at standards and quality of probiotics sold to you across the medical and wellness pharma spectrum and in great depth that is the highest standards in medical science and industry. We have the list (>100 products) and the pricing is being finalized. But, it you would like to get onboard and help us with early logistics, such as purchases and travel then please think about supporting us here with the minimum of ₹500 pages.razorpay.com/meshPromo… ...or wait for the full project to go live for specific levels of funding for the public, in a few weeks. We hope we can provide you with the highest quality of citizens science you'll ever witness in this era. Thank you in advance! - for Mission for Ethics and Science in Healthcare (MESH) meshindia.org

My dear friends, something important. I am deeply honored to share that I am one of the eight finalists globally shortlisted for the 2026 John Maddox Prize. Established in 2012 in memory of Sir John Maddox (the legendary former editor of Nature and Fellow of the Royal Society), this global prize, spearheaded by Sense about Science and supported by the Royal Society. It was previously co-awarded by Nature. And honors individuals who stand up for sound science and evidence in the public interest, advancing critical discussions despite facing hostility, powerful vested interests, and severe obstacles. For me, an India-based science communicator and clinician, this recognition carries immense weight. This is the very first time a resident from the Indian Subcontinent has been shortlisted for the Maddox Prize. Speaking truth to power against pseudoscience, predatory health misinformation, and unscientific traditional remedies in a cultural and political ecosystem that heavily endorse them, comes at a steep personal, legal, and professional cost. To stand alongside seven extraordinary global finalists—from public health researchers working under fire in Gaza, to scientists defending rigorous evidence in the UK, France, Bolivia, Mexico, New Zealand, and the US—is deeply humbling for me. I may or may not win. But with this shortlist, India’s advocacy for evidence-based medicine has a place on this global stage. Our patients, our public conversations and our struggles to defend scientific integrity matter beyond our borders. I hope this encourages more doctors and researchers across India, the wider subcontinent and West Asia to speak openly, engage the public and stand by sound evidence. Whatever the result, the work continues. Jai Hind. Please read the official announcement and details of other candidates here: senseaboutscience.org/activi…

For physicians and gastroenterology/liver specialists, we are happy to share our new work, published in @PLOSONE on the value of interleukin-6 (IL-6) in hospitalized patients with cirrhosis. Turns out, this inflammatory marker could be a pretty good predictor of death in hospital for patients with alcohol-related cirrhosis and infection. Here is a simple summary: 1. Admission IL-6 is predominantly a short-term prognostic marker that predicts in-hospital death. 2. IL-6 complements, but does not replace, established disease severity scores. 3. The strongest prognostic value was in alcohol-associated liver disease. 4. Infection accounted for only part of the IL-6–related death in patients association Cut-offs: (a) IL-6 ≥41.6 pg/mL: The optimal cutoff for in-hospital mortality (alcohol etiology + infection) (b) IL-6 <10 pg/mL: best negative predictive value For those interested, please read more on it here: Admission interleukin-6 as a time-limited, etiology-dependent prognostic signal in hospitalized cirrhosis – A frequentist and Bayesian cohort study journals.plos.org/plosone/ar…