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New paper: nature.com/articles/s41467-0… ! We finally get to see native chlamydial MOMP by cryo-EM: a trimer with three β-barrels topped by a folded antigenic cap. It is strange, beautiful, and full of clues for vaccine design. (1/5)
Cryo-electron tomography reveals OmpB is required for the Rickettsia parkeri S-layer doi.org/10.17912/micropub.bi…
The cap is where the immune story gets exciting: variable domains from all three protomers make one antigenic surface, and antibody binding reshapes it. This is why native structure matters for MOMP vaccine design. (4/5)
Seeing the structure makes old observations click — adhesion, redox, antibody recognition, vaccine design. Also: the transparent peer-review file has hidden gems; the reviewers pushed the story in the best way. Huge thanks to all co-authors! (5/5) utsouthwestern.edu/newsroom/…
Dominika Borek retweeted
A vaccine to prevent chlamydia, the most common sexually transmitted infection, could be closer to reality. #UTSW scientists helped map a key protein on the bacterium that causes chlamydia, offering hope for treating this source of serious health problems. bit.ly/4v1WNlP
Dominika Borek retweeted
The distinct trimeric structure of the immunodominant chlamydial antigen Major Outer Membrane Protein
nature.com/articles/s41467-0…
Dominika Borek retweeted
RFdiffusion3 now available! De novo protein design against any molecule
Try it on @tamarindbio today
RF3 shows success in designing de novo proteins against all-atom targets, including proteins, DNA and small molecules with diverse applications.
Dominika Borek retweeted
How can the same "master regulatory" protein mTOR recognize different sets of targets to separate nutrient and growth factor signals?
Thrilled to share our new paper, in which we reveal how mTORC2 recognizes Akt.
🧵 on our new paper in Science:
science.org/doi/10.1126/scie…
Dominika Borek retweeted
Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues | PNAS pnas.org/doi/10.1073/pnas.25…
Dominika Borek retweeted
First cryo-EM map of Apoferritin from our new @JEOL_Japan @JEOLUSA @JEOLEUROPE cryoARM300-II with @DirectElectron Apollo detector. Collected over night and processed in 1 day with @cryosparc using all-default settings from only 76k particles. H/R B-factor=28 at 1.5A. Not too shabby!
Dominika Borek retweeted
An evolving landscape of PRC2–RNA interactions in chromatin regulation, by Aguilar @ragmau, Rosenberg, et al. now in print!
Learn the latest about how Polycomb works with RNA in epigenetic regulation:
nature.com/articles/s41580-0…
Dominika Borek retweeted
Turns out they said yes! statnews.com/2025/07/21/casp…
Maybe @Google or @GoogleDeepMind should fund CASP, given their ample resources and how much they've benefited from the efforts of John Moult, Krzysztof Fidelis, Andriy Kryshtafovych, Nick Grishin, and many others.
science.org/content/article/…
Dominika Borek retweeted
🎉 Congrats to Yanhe, Kangkang, @AmirrasoulTava1, @loonggui & co-authors for revealing the atomic structure of RS3, a Giga-sized complex in motile cilia! A tour de force in #cryoET, #cryoEM,#proteomics & modeling. Out now in Nat Struct Mol Biol! doi.org/10.1038/s41594-025-0… @CellUtsw
Dominika Borek retweeted
AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys dlvr.it/TLpDHr
Dominika Borek retweeted
Our work, co-led by @AlfredoFlorez and @NicholasLue, is finally out in @NatureSMB. Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and Susanne Kassube for their contributions, and thanks to the reviewers for their suggestions that led to the final work.
nature.com/articles/s41594-0…
Dominika Borek retweeted
In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.
Dominika Borek retweeted
🍃➡️🧬 First paper from the Martynowycz Lab!
Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias.
Watch the diffraction-to-density movie & grab the preprint below!
biorxiv.org/content/10.1101/…
Dominika Borek retweeted
The 32nd paper from the #cryoEM facility in #KEK. Collaboration with Profs. Noji and Murata. Multi-stalk FoF1-ATP synthase was engineered to enhance H+/ATP ratio. Cryo-EM structures clearly showed the presence of multi-stalks! Outstanding work, Ueno-san!
nature.com/articles/s41467-0…
