medical writer working remotely from MPLS, MN. alum of @uutah @huntsmancancer and @northernmichu #blacklivesmatter
Joined January 2017
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Excited to share that my 1st author paper is out today in @Dev_Cell! Using mouse models, organoids, and human cell lines we have found that pioneer factors FoxA1 and FoxA2 are critical drivers of lung adenocarcinoma growth and transcriptional evolution 1/ authors.elsevier.com/c/1fPJU…
Tomorrow is the big day! I’ll be defending my dissertation at 11AM (MDT) in a hybrid format, so folks can attend via Zoom! Info below 👇🏼
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Grace Orstad, PhD retweeted
Online now: FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma dlvr.it/STrJpd
Mechanistically, loss of FoxA1/2 leads to aberrant NKX2-1 transcriptional activity and genomic localization, which in turn drives the expression of these non-proliferative identities, actively inhibiting growth in FoxA1/2-negative tumors 7/
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Grace Orstad, PhD retweeted
Proud to announce our latest @Dev_Cell publication:
Klf5 defines alveolar epithelial type 1 cell lineage commitment during lung development and regeneration
authors.elsevier.com/c/1fNBe…
Some exciting ~personal news~: I recently started writing freelance articles for @CD_AACR's #ResearchWatch section! Check out my article for this week's edition about an exciting paper in @ImmunityCP : aacrjournals.org/cancerdisco…
In my first article last week I summarized very exciting work published in @Nature by @SVanharanta's group beautifully demonstrating the relationship between lineage factors and driver mutations in ccRCC aacrjournals.org/cancerdisco…
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Grace Orstad, PhD retweeted
I remember breaking down to my Ph.D. advisor about how stupid I felt while troubleshooting a problem in my project when she handed me this paper. Years later it is still relevant to young students starting off in Science. It's ok to feel stupid, we all do on a regular basis.
Grace Orstad, PhD retweeted
before mRNA synthesis can take place, the DNA double helix must unwind to form the “transcription bubble” – at San Diego, CA
Grace Orstad, PhD retweeted
setting the record straight -- the lungs:
1) make sure your silly little other organs get oxygen
2) regulate your pH
3) control the blood return to your heart
4) regulate blood pressure via ACE
5) yes they get mad at the disrespect and irreversibly fibrose
6) look like this
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Grace Orstad, PhD retweeted
@graceorstad from @huntsmancancer presenting her thesis work on the role of FOXA1/2 in lung cancer at #EMBOCancerEvolution
Grace Orstad, PhD retweeted
Excited to share our work using a CRISPR-based lineage tracer to track tumor evolution from a single transformed cell to an aggressive tumor in a genetically engineered KP-Tracer model. It is a great collaboration of the @JswLab, @LabJacks and @YosefLab.
cell.com/cell/fulltext/S0092…
Grace Orstad, PhD retweeted
Our paper describing NEAT-seq, a method to simultaneously measure transcription factor protein abundance, ATAC-seq, and RNA-seq in single cells, is now out at Nature Methods! Congrats to Amy and Ben! nature.com/articles/s41592-0…
Grace Orstad, PhD retweeted
Students and faculty at @nyugrossman protesting the potential hiring of a David Sabatini today.
