Somewhere between ATCG and understanding. Damon Runyon Quantitative Biology Fellow, Jian Zhou lab at the University of Chicago
Chicago, IL
Joined April 2014
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We are excited to share our latest work, Mola, a sequence-to-distribution (S2d) model for single-molecule regulatory genomics. Gene regulation happens at the single-molecule level. Mola predicts single-molecule chromatin-state distributions from DNA sequence. (1/8)
We also want to highlight two other very exciting works about building sequence models for single-molecule data: SMFNet from Arnaud Krebs and Anshul Kundaje groups, and ChAI-Net from Katie Pollard and Vijay Ramani groups . doi.org/10.64898/2026.10.30.… doi.org/10.64898/2026.10.29.…
Our manuscript: doi.org/10.64898/2026.10.29.…
Web server: mola.zhoulab.io
Code: github.com/jzhoulab/mola
We welcome your feedback!
Ruoyu Wang retweeted
#GandE22
Waiting for our Genetics and Epigenetics community to descend on Moody Gardens - our first in person G&E retreat since the pandemic!
Ruoyu Wang retweeted
Great summary from Lasker foundation of this work recently form us and Ferreon team.
The #transcriptionfactor NANOG is one of two master regulators of pluripotency. What makes #NANOG so special? The fact that it’s disordered. NANOG oligomerization is essential for bridging DNA and facilitating distant chromatin interactions. @wli2019
ow.ly/8CPa50IXr41
Ruoyu Wang retweeted
A thread about the new paper by F. Xiong, R Wang et al., from Wenbo Li Lab ➡️ two stories in one 🙀
“RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability” 👇
nature.com/articles/s41422-0…