Wenbo Li retweeted
Are the enhancer regions that control the expression of lineage genes established from early embryonic stages or do they gain their transcriptional potential along differentiation? Today in @CellGenomics we address this question: tiny.cc/r5j0101 1/15🧵
Wenbo Li retweeted
1/5 People living with sickle-cell disease (SCD) face ↑ cancer risk, including #RenalMedullaryCarcinoma. Our latest @ImmunityCP study suggests a culprit is the reshaping CD8⁺ T cell chromatin by SCD 👉authors.elsevier.com/sd/arti… #MsaouelLab
Wenbo Li retweeted
To everyone in the U.S. standing up for science today, calling for policies that support science, not suppress it: we’re with you! Cutting science doesn’t just harm scientists – it harms society as a whole. #StandUpForScience
ALT Flyer for the DC and nationwide rally on March 7, 2025. "Stand up for Science", "Science is for everyone".
A nice program on RNAs and cancer.
For anyone interested in RNA and cancer (basic and translational research), please consider submitting an abstract for this exciting meeting! We will be choosing lots of talks from abstracts. Should be a great event! #aacrRNA24
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Extremely useful co-assay of RNA and HiC! Wonderful work from @jmuiuc and Zhijun Duan!
Happy to share the final version of our #GAGEseq published today @NatureGenet! The single-cell co-assay for #scHiC and #scRNA reveals 3D genome & gene expression interplay in mouse cortex (also integration w/ #MERFISH) and during human hematopoiesis. 1/3 nature.com/articles/s41588-0…
Very interesting paper!
Glad that our sequence model of promoters in human genome is now published in @ScienceMagazine. Check out the paper for a deep dive into the sequence basis of transcription initiation at the basepair level: science.org/doi/10.1126/scie…
A new way to do protein degradation!
Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: drive.google.com/file/d/18hu…
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Wenbo Li retweeted
Our Center for Translational Cancer Research at UTHealth Houston IMM is hiring! Great opportunity for those interested in cancer biology, drug discovery, and therapeutics. Apply here: jobs.sciencecareers.org/job/…
A major breakthrough for genetic therapy!
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A great meeting on genome organization CSHL 2024 - must go!
Check out the upcoming Cold Spring Harbor meeting on Genome Organization & Nuclear Function, Apr 20 – May 4, 2024, on advances in spatial and temporal aspects of nuclear structure & function. We look forward to seeing you! @WickstromLab @jane_skok @belmont_andrew @cshlmeetings
Wenbo Li retweeted
Excited about the upcoming @Fusion_Conf meeting 'From Genetic Discoveries to Gene Function in Human Diseases' and the opportunity to connect with so many brilliant scientists!
Our current speaker line up for the 'From Genetic Discoveries to Gene Function in Human Diseases' Conference is looking great, with many more to be announced soon! #GWAS24
Register now to join us in Portugal next July!☀ ⛳
Find out more➡️fusion-conferences.com/confe…
UTHealth Houston @UTHealthHouston Biochem and Mol Biology department has a faculty opening for AP. Please apply or spread the news. nature.com/naturecareers/job…
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UTHealth Houston @UTHealthHouston Biochem and Mol Biology department has a faculty opening for AP. Please apply or spread the news. nature.com/naturecareers/job…
Wenbo Li retweeted
Happy birthday, GSBS! #WeAreGSBS
Today is the school's 60th anniversary, and we will celebrate with a kickoff event starting at 5 p.m. in the outdoor patio space between McGovern Commons (6550 Bertner) and the TCH-NRI. We look forward to seeing you there! #GSBS60 #WeAreGSBS
Wenbo Li retweeted
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience cell.com/cell/fulltext/S0092…
Paper 2: scATAC + GWAS + Epigenome Erosion cell.com/cell/fulltext/S0092…
Paper 3: Microglia States + reprogramming cell.com/cell/fulltext/S0092…
Paper 4: DNA damage + gene fusions cell.com/cell/fulltext/S0092…
MIT News: news.mit.edu/2023/decoding-c…
Issue: cell.com/cell/current
News & Views: cell.com/cell/fulltext/S0092…
Interesting tool from Katy Pollard lab to predict 3D genome.
new from my @GladstoneInst @UCSF colleagues led by @lauragunsalus in Katie Pollard's lab, in silico predictions of genomic features regulating 3D genome folding. In @CellGenomics cell.com/cell-genomics/fullt…
Wenbo Li retweeted
Loop stacking organizes genome folding from TADs to chromosomes dlvr.it/Snd6PC