🧬 At @InSilicoMeds, we give frontier AI models a protein and ask one deceptively simple question. Actually, thousands. Which parts can change, and which absolutely can't? Some amino acids are tolerable for mutation. Others are so important that changing just one can break the protein. Our Structural Biology benchmark measures how well AI can tell the difference using only the protein's structure and sequence context. 🏆 Grok led this run at predicting which changes proteins can tolerate, well done @grok 🛡️ Opus was close behind and stood out at identifying the amino acids most critical to protein function, strong result @AnthropicAI Plenty of room for the leaderboard to change with the right structural and evolutionary training data. You know where to find it. 😉