Zetta CEO, reconstructing connectomes
Joined February 2009
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Thomas Macrina retweeted
The year is 2030. Global pacing of AI is in effect, flowing billions of dollars of capital toward unregulated cognitive substitutions. Connectomes explode as an industry, but it is the parallelizable, controllable fly brain which dominates.
Welcome to the drosophila century.
🤖 Made with AI
Thomas Macrina retweeted
the single thing that would most accelerate our work at @ScienceCorp_ is a connectome
the mouse is probably only ~$300M away, something highly worth funding
Introducing a complete map of the male fruit fly brain and central nervous system, created in partnership with @HHMIJanelia. With over 166,000 neurons, this is the largest cellular brain map to date. Learn more: goo.gle/4qQTtIW
Thomas Macrina retweeted
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @PrincetonNeuro. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s41593-026-0… (1/3)
Thomas Macrina retweeted
Just published yesterday, the #BANC! A full central nervous system (CNS) connectome of a limbed animal enables us to trace sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS #neuroscience @Nature, Video by @quorumetrix, sound on! 1/18
Thomas Macrina retweeted
It took endless hours in the lab and a massive effort, but we're finally here: Eyewire II is officially out!
Huge thanks to our amazing co-authors and everyone else who supported us along the way. So grateful for the hard work—it’s been a privilege pushing through this together.
Meet Eyewire II: a new connectomic resource for the mouse retina.
~1 mm² of retina at nm resolution, with synapses and circuits of ca. 100,000 neurons + visual responses from the ~400 neurons shown in the video!
Preprint: doi.org/10.64898/2026.05.28.…
Data: eyewire.ai/
Thomas Macrina retweeted
Meet Eyewire II: a new connectomic resource for the mouse retina.
~1 mm² of retina at nm resolution, with synapses and circuits of ca. 100,000 neurons + visual responses from the ~400 neurons shown in the video!
Preprint: doi.org/10.64898/2026.05.28.…
Data: eyewire.ai/
Thomas Macrina retweeted
zenodo.org/records/19697471
Love seeing an up-leveled ambition to tackle the conn-economics (though I personally vote optical)
Thomas Macrina retweeted
The Wiley Foundation is pleased to announce the winners of the 24th annual Wiley Prize in Biomedical Sciences, which recognizes contributions that open new fields of research or advance concepts in a particular biomedical discipline.
John White, Gerald Rubin, Sebastian Seung, and Mala Murthy will be awarded for reconstructing and interpreting connectomes, the anatomical wiring diagrams of neurons and synapses that underlie how the brain processes information and controls actions.
Learn more about the winners in our latest press release: ow.ly/qzgT50YhCAP
ALT Four diverse individuals honored as winners of the 24th annual Wiley Prize in Biomedical Sciences.
Thomas Macrina retweeted
nature.com/articles/d41586-0…
Optical connectomics (LICONN + FRO @E11BIO’s recent PRISM method) featured by Nature as one of 7 technologies to watch in 2026. Nature you are not wrong imnsho!
Thomas Macrina retweeted
For over twenty years, many dedicated researchers around the world have worked to realize the dream of connectomics. I'm especially indebted to the talented members of my laboratory, past and present. And I've been lucky to benefit from so many powerful collaborations.
The winner of the 2026 Pradel Research Award is H. Sebastian Seung (@SebastianSeung) of @PrincetonNeuro! He is being honored for for transformative advances in computational neuroscience. Learn more about his discoveries: nasonline.org/award/pradel-r… #NASaward #neuroscience
Thomas Macrina retweeted
One of my favorite chats of the year here with @SebastianSeung on his new company, brain research, the nature of intelligence and where neuroscience and AI are heading together.
You can find the @corememory pod on all major platforms and on YouTube down below.
Thx, as always, to @brexHQ and @e1ventures for supporting our show!
corememory.com/p/the-next-st…
Thomas Macrina retweeted
Transcend biology.
Big scoop today. Connectome lord @SebastianSeung has a new start-up trying to build a digital brain corememory.com/p/exclusive-c…
Thomas Macrina retweeted
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
nature.com/articles/s41592-0…
Thomas Macrina retweeted
Happy to share the first paper from my journey at @psich towards X-ray connectomics, now out in @naturemethods: nature.com/articles/s41592-0…
Thomas Macrina retweeted
#paper!
X-rays can resolve #ultrastructure in #tissues non-destructively.
nature.com/articles/s41592-0…
Shoutout to key collaborators at @TheCrick and @psi_eng Ana Diaz, @AdrianAWanner and @AndreasTSchaefer, and to the whole team that made this possible.
Thomas Macrina retweeted
Published today in Nature Biotechnology!
In 2022, we set out to prove that you don’t need electron microscopy to see brain circuits in molecular detail. With iterative 20x expansion and pan-protein staining, molecular connectomics is possible!
nature.com/articles/s41587-0…
Thomas Macrina retweeted
Excited to share the preprint of our new State of Brain Emulation Report 2025! We reassess progress since the 2008 brain emulation roadmap by @anderssandberg & Bostrom across organisms from C. elegans to humans, identify current bottlenecks and propose a path forward.
1/N
Thomas Macrina retweeted
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live and free to use and explore. Find out more at the landing page hosted by our Janelia FlyEM collaborators janelia.org/project-team/fly….
ALT A multicolour 3D rendering by Philip Hubbard (Janelia) of neurons in the male brain and nerve cord connectome.