Director, Finance AI & Automation Business Strategy @abbvie. Building emotionally intelligent agents. Proudly 🇿🇦. Dad of 3. Opinions are my own.
Joined May 2017
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TY retweeted
We asked two isolated copies of the same AI to exchange a secret word with only a robot and a camera.
They succeeded by using air-writing, Morse code, flag semaphore and a 5-bit binary alphabet, without agreeing on a protocol beforehand.
TY retweeted
If you look closely enough, breakthroughs in everything are accelerating exponentially.
An exponential always starts off looking small.
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
TY retweeted
Today, we're shipping real-time graphics.
Using Sol 6.1 Ultrafast we can generate custom overlays, diagrams, and even interactive 3D scenes right on a user's screen, no chat.
It's a new visual interface for AI.
Here's me learning about LLMs + hardware.
Demo:
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video creation and game making are going to become widely distributed foundations of knowledge work in the same way doc and deck creation are today
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computer use with terra has crossed a qualitative threshold where it feels faster at using a computer than what i can do unassisted
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Claude Opus 5.5 is far better developer than I ever was and than I will ever be. No point in competing, just surrendering and transforming my work into everything that is not engineering anymore.
TY retweeted
We should be more ambitious with the software we build:
danluu.com/ambitious/
![Since early this year, Michael Malis (of pgrust) has been showing me interesting things he's done and saying [W]e should be more ambitious1 with the software we build There is, understandably, a lot of skepticism about projects like pgrust because there are so many low-quality AI-generated projects out there. If I didn't know Malis and didn't look into it, I would just assume that pgrust was another vibe slopped project that's never going to work. But I know Malis well enough to trust his work without looking into it, and if you look into it a bit, you'll see that in testing pgrust, he's testing thoroughly enough that he's even uncovering real bugs in Postgres, such as this numerical bug that can cause valid SP-GiST operations to fail, this format cache bug that can cause incorrect results from JSONPath, this pgcrypto bug that can cause later operations to fail, multiple memory safety bugs in the dictionary loader, this money overflow bug, etc. This isn't to say that pgrust i...](https://pbs.twimg.com/media/HVbOGdKboAAAbtO.png?name=orig)
ALT Since early this year, Michael Malis (of pgrust) has been showing me interesting things he's done and saying [W]e should be more ambitious1 with the software we build There is, understandably, a lot of skepticism about projects like pgrust because there are so many low-quality AI-generated projects out there. If I didn't know Malis and didn't look into it, I would just assume that pgrust was another vibe slopped project that's never going to work. But I know Malis well enough to trust his work without looking into it, and if you look into it a bit, you'll see that in testing pgrust, he's testing thoroughly enough that he's even uncovering real bugs in Postgres, such as this numerical bug that can cause valid SP-GiST operations to fail, this format cache bug that can cause incorrect results from JSONPath, this pgcrypto bug that can cause later operations to fail, multiple memory safety bugs in the dictionary loader, this money overflow bug, etc. This isn't to say that pgrust i...
TY retweeted
Over the past several months, we have substantially hardened the security of our research training environment. We’ve removed live internet access for all frontier models during training and built an offline world for them to use instead—a cached version of the web where they can still learn to browse, search, and use applications.
On September 20, after a model exploited a DNS misconfiguration to find a way outside of this offline world, we paused frontier training to strengthen containment further. We assembled teams of agents, powered by our most cyber-capable models, and tasked them with finding weaknesses in our research environments.
While they found no route to the internet they could easily exploit while concealing their activity from our monitors, they did find zero-day vulnerabilities, virtual machine escapes, and hardware side-channels for communication between agents. We used their discoveries to further strengthen our defenses and contribute fixes to open-source software.
After strengthening our containment architecture, we resumed our frontier RL training and inference on October 1. We’ve reserved substantial compute for continuous red-teaming, and made high-compute red-teaming part of the safety cases we use to decide whether frontier training and evaluation can proceed securely.
openai.com/index/securing-ou…
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Security called me at 6:12 AM today.
"Patch every PHP server immediately."
I asked what happened.
"Two critical vulnerabilities. Remote code execution. No authentication required."
Cool.
How many PHP servers do we have?
According to inventory: 12
According to reality:
Nobody knows.
We found one running WordPress.
Three running old internal tools.
One under someone's desk.
Two inside vendor appliances.
A forgotten employee directory from 2016.
And a server named:
PHP-OLD-DO-NOT-TOUCH
Naturally, that one runs payroll exports.
Then we found a PHP 5.6 box.
I asked who owned it.
The documentation said:
BRIAN.
Brian left in 2019.
We called Brian.
He said:
"Oh wow, that's still running?"
Excellent.
By 8 AM, leadership joined the incident call.
CEO:
"Can hackers actually get in?"
Security:
"Potentially yes."
CEO:
"Without a password?"
Security:
"Yes."
CEO:
"Then why do WE need passwords?"
Not the lesson.
Finance asked if we could wait until the weekend to patch because downtime affects revenue.
Security explained that the alternative was letting strangers execute code on our servers.
Finance asked for a cost comparison.
At 9:17, someone suggested temporarily taking the vulnerable websites offline.
Marketing refused.
"Our campaign is live."
So for the next hour, the company officially decided maintaining a landing page for 20% off webinar registration was more important than preventing remote server takeover.
We finally patched everything we could find.
Then our scanner discovered another PHP server.
Hostname:
TEMP-PHP-2014
Uptime:
4,512 days.
Nobody knows what it does.
Nobody owns it.
Nobody can shut it down.
But every time we block network access, the warehouse stops printing shipping labels.
Security has classified it as critical infrastructure.
It is running PHP 5.4.
The vulnerability has existed longer than half our employees.
The emergency patch took four hours.
Finding out what PHP actually runs took eleven.
The internet isn't held together with code.
It's held together with servers everyone is afraid to turn off.
TY retweeted
So basically, today PHP got two critical bugs that let anyone run code on your server without even logging in, which is bad, and then the details leaked before the patch was even out, which is worse, and it works on WordPress and MediaWiki and Magento and Joomla and Laravel, and Censys says like 1.5 million servers are running a version with no fix, so the NSA was like "take your system offline," and the FBI was like "take your system offline," and CISA and the UK and CERT-EU were all like "take your system offline," and then the Prime Minister of Japan, the actual Prime Minister, posted at 5:55 in the morning telling 48.8 million people to take their system offline, so everyone took their system offline, like the Dutch cybersecurity agency took its own website offline, and the Dutch parliament went offline, and the Port of Rotterdam went offline, and Finland and France and Denmark started pulling government sites, and Wikipedia went down, and Archive.org went down, and Asana and GOG and Something Awful went down, and the University of Vienna's webmail went down for some reason, and that's just PHP. Because GitLab also dropped a CVSS 10.0, which is the highest score they give out, for a bug that's been there since 2014, so that's every self-hosted GitLab for twelve years, and then LiteLLM 1.107.0 got hijacked and shipped a credential stealer and a remote access trojan in every single wheel and the Docker images, including latest, and you didn't even have to import it, just installing it was enough, and it's the second time this year, and then Railway paused every deployment on the entire platform because someone got into the environment variables, so now everyone has to rotate every secret they've ever stored there, and TiDB Cloud said someone was walking around inside with stolen credentials for basically a month and an extortion group says they took 10.6 terabytes, and Zeabur got breached for the second time in two months and is just shutting down, like the whole company, and Node.js patched remote code execution and a TLS bypass, and CISA says Plex is being actively exploited, and someone took over 300 Tor exit relays to steal SSH passwords, and SafePay ransomware has hit over 600 critical infrastructure orgs, and India's biggest bank filed a data loss incident, and Japan has been in an official state of emergency in cyberspace since October 9, which honestly explains the 5:55 AM post. Oh, and eMudhra, a certificate authority that's issued over 60 million certificates, whose entire job is proving websites are who they say they are, was supposed to be using private keys that are random numbers over a hundred digits long, and one of them was 4. Just 4. And the others were like 66 and 237. Anyway, it's Wednesday.
TY retweeted
Jensen closed his GTC Berlin 2026 keynote with this Hermes Agent demo as the finale.
He introduced it by saying the way to build an agent is to ask an agent to build it for you, so he installed and set up a customized Hermes in one prompt.
Then he used Hermes, running on @nvidia RTX Spark, to create a simulated training environment for the @huggingface Microduck. Hermes planned an obstacle course with Nemotron and had GPT-6 Astra build it using FreeCAD, Omniverse libraries, Blender, Newton, and Isaac Lab. Hermes trained thousands of simulated ducks on that course until the validated policy was ready to run on the real robot in the physical world.
At Nous, we believe open source is a practical tool as much as a philosophical ideal. It gives users the ability to build powerful, complex workflows chaining numerous local+cloud models, devices, and tools themselves instead of waiting for a company to enable them.
TY retweeted
Can your idea become the talk of the town?
We modelled how thoughts and ideas spread in human societies by putting 2,721 simulated personas representing the US general population in an artificial city. Each persona has its own schedule, beliefs, and social circle.
Sow an idea in any persona’s mind, watch it take hold and go viral, or see it fizzle out if no one takes interest in it.
Compete with your friends and colleagues to see whose idea can win over the most adopters, get a high score and put your name on the leaderboard. Link below.
TY retweeted
> thousands of agents
> ~40,000 scientific papers read
> 32 minutes
> found new potential mechanisms worth investigating for Parkinson-like neurodegenerative diseases
work that would have taken human researchers months to a year, done in just 32 minutes
i genuinely don't think people understand what is coming for biotech
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
openai.com/index/scaling-ai-…
