I love science! I study how microbes survive and thrive. @wellcometrust Sir Henry Wellcome Fellow | All views my own | he/him | 🏳️🌈
Deep, deep underground with all the hot …
Joined January 2018
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William P J Smith retweeted
New paper alert! Toxins can skew the results of competition assays, fascinating short communication from @Prokaryota and @willpjsmith. @MicrobioSoc microbiologyresearch.org/con…
William P J Smith retweeted
What amount of eye disease research would have discovered the laser? How much virology would have discovered lipid nanobody mRNA delivery? How many disease genes would you need to find before you discovered CRISPR?
Sometimes the hardest problems need discoveries in other fields
As a taxpayer (irrespective of whether you’re a scientist) would you would be in favor of more of the @NIH budget going to fund efforts to solve specific diseases at the expense of basic exploratory research? Which diseases?
William P J Smith retweeted
Recruiting two Chair positions. Areas of interest incl. but not limited to:
🤖 advanced computation & AI
🌱 natural product biosynthesis & enzyme discovery
🧬 structural biology & mechanistic enzymology
🦠 microbial engineering
CLOSING DATE: 31/01/25
jobs.manchester.ac.uk/Job/Jo…
William P J Smith retweeted
Climate impacts on European soils predicted by scientists
Our paper’s out @Nature !
Read about it here:
manchester.ac.uk/about/news/…
Or the original here: doi.org/ntzk
With @frantecol and many others
William P J Smith retweeted
Interested in doing a PhD studying fungal natural products?
I have two PhD projects advertised through @MIBTP_BBSRC at @uniofwarwick 1/ discovery of bioactive molecules for use in crop protection 2/understanding the biosynthesis and mode of action of pleurotin
🍄🧬💊
Please RT
William P J Smith retweeted
Delighted to be a recipient of one of these with a fantastic group of scientists - @edith_houben @MarlovitsLab and John McKinney. Look out for CombaT7!
📣 Results of the 2024 ERC Synergy Grant competition are out!
57 research groups won a total of €571 million in #ERCSyG funding, enabling them to pool diverse expertise & resources to push the frontiers of knowledge.
👉 europa.eu/!bmpNW9
🇪🇺#EUfunded #FrontierResearch
William P J Smith retweeted
Very cool! Congrats on this impressive work!
🚨🔬Excited to share our new paper now out in @NatureMicrobiol!
Using Tn-seq + live imaging in engineered airway organoids, we explored the fitness tradeoffs P. aeruginosa faces while growing and surviving antibiotic treatment on the mucosal surface.
🔗 rdcu.be/dX4RR
William P J Smith retweeted
Out now @biorxiv_micrbio, one of the main publications of my postdoc @Basler_Lab 🥳 more on this soon 😁
Mechanisms of P. aeruginosa resistance to Type VI Secretion System attacks biorxiv.org/cgi/content/shor… #biorxiv_micrbio
William P J Smith retweeted
Now published in Royal Society Interface @RSocPublishing! doi.org/10.1098/rsif.2024.05…
A new preprint! We observed synchronised growth oscillation in filamentous fungi Serendipita indica. Led by @praneetpg, collaboration with @osslab @PolinMarco! doi.org/10.1101/2023.12.22.5…
William P J Smith retweeted
Published today in @EvolLetters 🎉🎉
Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome academic.oup.com/evlett/arti…
A short thread 🧵:
William P J Smith retweeted
Multiple variants of the type VII secretion system in Gram-positive bacteria
@microLifeJrnl by @StephenRG97 @AndyBHigginson and @proftracypalmer
academic.oup.com/microlife/a…
William P J Smith retweeted
New preprint from the lab:
Microbial interactions affect the tempo and mode of antibiotic resistance evolution. biorxiv.org/content/10.1101/…
William P J Smith retweeted
Pseudomonas aeruginosa senses and responds to epithelial potassium flux via Kdp operon to promote biofilm
@PLOSPathogens from Jennifer M. Bomberger
with @DominiqueLimoli @catarmbruster
journals.plos.org/plospathog…
William P J Smith retweeted
Estimating mutation rates under heterogeneous stress responses
@PLOSCompBiol by @LanjuLucy from @HelenKAlexander
journals.plos.org/ploscompbi…
William P J Smith retweeted
Bacteriocin diversity, function, discovery and application as antimicrobials
rdcu.be/dHzpA
Sugrue, Ross & Hill discuss advances in bacteriocin research, new bioengineering approaches for improved activity, & their application in microbiome modulation and clinics
William P J Smith retweeted
T6SS nuclease effectors in Pseudomonas syringae act as potent antimicrobials in interbacterial competition
-in @JBacteriology
journals.asm.org/doi/10.1128…
William P J Smith retweeted
What makes a temperate phage an effective bacterial weapon?
@mSystemsJ from @katcoyte
journals.asm.org/doi/10.1128…
William P J Smith retweeted
Calling for talent! If you know students looking for a funded PhD studentship to work on an exciting physical biology project, here is an opportunity! Open until 23 May. @MIBTP1 #bioelectricity #PhD warwick.ac.uk/fac/cross_fac/…
William P J Smith retweeted
I might be biased, but Streptomyces are pretty cool: They not only make lots of antibiotics but also secrete umbrella toxins to interact with their microbial neighbours. Streptomyces umbrella toxin particles block hyphal growth of competing species nature.com/articles/s41586-0…
