@xue_lab

UMass Med researcher using CRISPR/Cas9 for #lung/#liver #cancer and rare genetic disorders

 Worcester, MA
umassmed.edu/xuelab/
Joined October 2015
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  • Following141
  • Followers615
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📰 Hot off the press from the Xue & Sontheimer labs: Prime assembly enables precise genomic insertions up to 11 kb in cells, providing a universal strategy to correct many pathogenic mutations within a gene. Read it here @Nature: buff.ly/dYn0NjS @xue_lab @UMassChan
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Prime assembly with linear DNA donors enables large genomic insertions biorxiv.org/content/10.1101/… #biorxiv_biochem

Prime assembly with linear DNA donors enables large genomic insertions

Targeted insertion of large DNA fragments has promising applications for genome engineering and gene therapy[1][1],[2][2]. Twin prime editing (PE) guide RNAs (pegRNAs) have enabled relatively large...

biorxiv.org
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The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells go.nature.com/3X6mOBv
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The RTI & @UMassChan Medical School seeks the next generation of scientific leaders! Join our research community as a Maraganore Early Independence Fellow. Get 3-5 years of support. Apply by Dec 1 to join us: academicjobsonline.org/ajo/j…
The goal of the UMass Chan Early Independence Fellows Program is to recruit clusters of exceptionally talented junior scientists with the potential to become independent investigators at UMass Chan Medical School, and to provide them with career development, mentoring, and financial support to foster their scientific excellence and leadership. In recognition of diversity as a driver of innovation and scientific impact, we are committed to building and sustaining an inclusive environment with talented individuals from all backgrounds, including backgrounds that are underrepresented in medicine and the biomedical sciences, who embrace diversity, equity and inclusion in line with our institutional goals (IMPACT 2025). Candidate evaluations will consider the unique scientific contributions of the candidate as well as leadership and resilience qualities the candidate brings to the program.

ALT The goal of the UMass Chan Early Independence Fellows Program is to recruit clusters of exceptionally talented junior scientists with the potential to become independent investigators at UMass Chan Medical School, and to provide them with career development, mentoring, and financial support to foster their scientific excellence and leadership. In recognition of diversity as a driver of innovation and scientific impact, we are committed to building and sustaining an inclusive environment with talented individuals from all backgrounds, including backgrounds that are underrepresented in medicine and the biomedical sciences, who embrace diversity, equity and inclusion in line with our institutional goals (IMPACT 2025). Candidate evaluations will consider the unique scientific contributions of the candidate as well as leadership and resilience qualities the candidate brings to the program.

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The Anderson lab and @xue_lab identified an ideal lipid nanoparticle to deliver mRNA and CRISPR components into lung tissue. Published in Nature Biotechnology, the research demonstrated that we could effectively edit genes in the lung airway epithelial cells.
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This paper has moved on to Round 3 of the bracket-style competition STAT Madness, assembled by STAT News. Voting closes on Thursday, March 21, at 11:59 p.m. Click on the UMass Chan logo to vote. statnews.com/feature/stat-ma…

STAT Madness Application

statnews.com
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The @xue_lab's paper is the last one standing from UMass, so please help our colleagues continue on to the Elite Eight by voting again; five days left of voting! Click on the link below, sign in, look for UMass Chan icons, and VOTE! statnews.com/feature/stat-ma…

STAT Madness Application

statnews.com
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Lowe Lab (2005-2015) – at Manhattan, NY
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I am honored to attend the Lowe lab 25 years reunion. Lots of great memories. Thank you, Scott!
Lowe Lab@LoweLabMSKCC19 Sep 2023
What an incredible Reunion! It was wonderful to see all former lab members who traveled to NYC from all over the world & to experience the joy that we all shared in getting together. THANK YOU & stay in touch! #LoweLab25
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Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates go.nature.com/48hmu76
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T-10 days to the '25 Years of Lowe Lab' Reunion! Looking forward to welcoming back 80+ alumni for two days of science, memories, and catching up. Will continue to highlight lab alums over the coming days. #LoweLab25 – at Manhattan, NY
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Lars was also a great co-mentor to students. He and Wen Xue teamed up on some of the most important papers from the lab. Wen now has his own lab focusing on genome editing @UMassChan – check it out @xue_lab! -SWL #LoweLab25 – at Manhattan, NY
Lars Zender & Wen Xue at CSHL.

ALT Lars Zender & Wen Xue at CSHL.

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Congrats to Wen Xue, PhD, Scot Wolfe, PhD, and Erik Sontheimer, PhD, for receiving a new @theNCI grant to use in vivo prime editing for #precision #cancer models. @xue_lab @ESontheimer_lab @ScotWolfe1 @UmassChan @RTI_UMassChan
Photos of Erik Sontheimer, Wen Xue, and Scot Wolfe

ALT Photos of Erik Sontheimer, Wen Xue, and Scot Wolfe

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Replying to @NatureBiotech @kochinstitute @MITChemE @UofTPharmacy @RTI_UMassChan @UMassChan @BostonChildrens @MIT_IMES @RareDiseaseCure @xue_lab @BowenLi_Lab
New nanoparticles can perform gene editing in the lungs #NBTintheNews via @MIT news.mit.edu/2023/new-nanopa…

New nanoparticles can perform gene editing in the lungs

A new type of nanoparticle can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins. Researchers hope to use them to develop new treatments for cystic fibrosis...

news.mit.edu
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Join #SCGE investigator Shunqing Liang, PhD at #ASGCT23 for a presentation on "Develop combinatorial non-viral and viral CRISPR delivery for lung diseases." 📍: SCGE Scientific Symposium 🗓️: May 19 ⏰: 11:00 AM Symposium agenda: annualmeeting.asgct.org/prog…
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And read the Research Briefing here: nature.com/articles/s41592-0…
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PE-Tag developed by Scot Wolfe and team @UMassMedical is an efficient genome-wide approach to map off-target effects of in vitro and in vivo genome editing. nature.com/articles/s41592-0…
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#SCGE PIs Daniel Anderson of @MIT and Guangping Gao and @xue_lab of @UMassChan designed a new nanoparticle for highly efficient RNA delivery to the lungs. Read more ⬇️ #nanoparticles #RNAdelivery #geneediting #therapeutics
Inside Precision Medicine@Inside_PM30 Mar 2023
New Nanoparticles Carrying #mRNA Can Perform In-Lung #GeneEditing A new nanoparticle that carries an mRNA payload may offer a method to provide treatment for #cysticfibrosis and other #lungdiseases. Learn more: ow.ly/ljYG50Nw80M
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Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing go.nature.com/3KlMaFA
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#PublicationFriday📚 In this recent paper, #SCGE PIs @ESontheimerLab and @xue_lab use multiomics to identify elements of hepatoblastoma, a rare tumor of the liver pubmed.ncbi.nlm.nih.gov/3593…
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