Postdoctoral Fellow @ University of Toronto | Yudin Lab | PhD @ University of British Columbia | Perrin Lab
Toronto, Ontario
Joined March 2016
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Shambhu Chandra retweeted
With gratitude to reviewers, we are thrilled to report on a new type of hybrid drug: Baited SELEX: Drug-Directed Selection of Aptamers to PSMA for In Vivo Targeting of Prostate Cancer in Mice pubs.acs.org/doi/10.1021/jac… @PCR_news @BeatPCa @prostatecanada @PCFNews @AptamerSociety
Shambhu Chandra retweeted
Honored to report single-molecule fluorescent 18F-PET tracers targeting PSMA for multi-modal imaging prostate cancer; grateful to reviewers at J. Med. Chem. pubs.acs.org/doi/full/10.102… #ProstateCancer #PETimaging #DualModeTracers #MolecularImaging #Radiochemistry #CancerDiagnostics
Shambhu Chandra retweeted
With ‘beaker mugs’ and icicles, UBC's resident glassblower, Brian Ditchburn, raises money for charity in his daughter’s memory: bit.ly/4fyle1X
@UBCChem
@ubcscience
Shambhu Chandra retweeted
Just on line with gratitude to reviewers (for amatoxin synth): the most concise enantioselective chemical synthesis of dihydroxyisoleucine to date (no transition-metals, no CN, no RLi). pubs.acs.org/doi/10.1021/acs… #organocatalysis,#synthesis,#smallmolecules,#peptides,@HeidelbergPharm
Shambhu Chandra retweeted
Glad to see our work amongst the most read papers in February @angew_chem
The most read papers in February include contributions by @WickensGroup, @Mykhailiukchem, @ritter_lab, @MinakataLab, @PerrinLab
See the full list: ow.ly/16iZ50QLmMh
Shambhu Chandra retweeted
Little-known fact: a sulfiliminium has a pKa ~ 8.
A poll: is a sulfilimine bio-isosteric for a sulfoxide (i.e. Ki's will be within 10x, i.e. <1.4 kcal)?
To test: compare a classic toxin (amanitin) & a drug (Fulvestrant) with their sulfilimine congeners.
We're about to find out..
We are delighted to share that our latest work from @perrinlab features in the virtual poster about the simplified approach for producing enantiopure beta prolines. Thank you @MatthewHorwitz1 and synthesis workshop team.
How would you make beta-proline? Join us this week as Shambhu Deo Chandra shares his approach from the Perrin group at University of British Columbia in a virtual research poster!
Check out the paper in Synthesis (DOI: 10.1055/a-2145-5470)! @thiemechemistry
It is truly remarkable that the research conducted by undergraduate honors student is being published, as it has the potential to greatly enhance the economical accessibility of beta-proline enantiomers.
Enantiomerically pure beta-proline is expensive! We report an economic synthesis of both enantiomers, even practicable by undergrads - cheaper to make than buy! Price dropping now at: thieme-connect.com/products/…
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I had the privilege of attending a week long American Peptide Symposium #APS2023.
It turned out to be a great evening as I won one of The Dr. ELIZABETH A. SCHRAM AWARD 2023 young Investigator at Scottsdale Arizona. @perrinlab
Shambhu Chandra retweeted
Honored to have our artwork featured on the cover of Angewandte - well done J. Lozada! onlinelibrary.wiley.com/doi/…
Shambhu Chandra retweeted
Last week we queried on the reactivity of BF4; 64% said “Reactive”. Indeed! We are pleased to report that BF4 readily and (unexpectedly for us) very rapidly fluorinates RB(OH)2 in a Salt Metathesis Rxn: @Boron_Chemistry #chemistry #CrossCoupling onlinelibrary.wiley.com/doi/…
Shambhu Chandra retweeted
Join UBC as PDF ✍
Postdoctoral Position in Radiopharmaceuticals - please RT!
@ubcchem #cancerresearch #Postdoc #ChemTwitter #Cancer #Biology #BiologicalSciences #AcademicTwitter #postdocjobs #STEM #MedTwitter #Science #sciencejobs #Biochemistry postdocs.ubc.ca/ad/56562
Shambhu Chandra retweeted
From "the neighborhood," David M Perrin with the University of British Columbia, presents his talk "Improving on Alpha-Amanitin, one of Nature’s Most Toxic Peptides – Synthesis of More Cytotoxic Analogs, Bioconjugation and Use in Peptide-Directed Targeted Therapy." #Peptides2022
Shambhu Chandra retweeted
Our work is in some sense a "baby" gestated during the Covid-19 pandemic and has seen three waves of the pandemic! Thanks are due to my mentor @ayanban7 for encouraging us to pursue our ideas independently, for sharing useful experimental insights and encouragement during...
Congratulations to CESSI PhD student @amardeochandra1 for his critical contributions to our #MakeInIndia instrument initiative; @ayanban7 @ydnad0. Work funded by @iiserkol @EduMinOfIndia @IndiaDST
Shambhu Chandra retweeted
The Perrin lab seeks a postdoctoral fellow to work on true radiotheranostics; to be considered, you should have published on radiometallation/radiofluorination; see chemistry-europe.onlinelibra…, @BlackInChem @Chemjobber @SNM_MI @GRCTheranostics
Shambhu Chandra retweeted
UBC's latest M.Sc. candidate: Somdeb Paul just defended his thesis on modified DNAzymes that use cationic amines instead of M2+; congratulated by the committee of examiners, we're proud of Somdeb for seeing this to completion - well done!
Shambhu Chandra retweeted
Sorry if this duplicates a posting: still thinking that catalytic nucleic acids have a place in neutralizing pathogenic mRNAs (anyone recall ribozyme pharma), just need to find ways to do it efficiently w/o Mg2+; is there viral mRNA that we should be concerned about these days?
Selection of M2+-Independent RNA-Cleaving DNAzymes with Side-Chains Mimicking Arginine and Lysine (Perrin) @perrinlab onlinelibrary.wiley.com/doi/…
Shambhu Chandra retweeted
Just out - our report on selected M2+-free RNA-cleaving DNAzymes with only amines/guanidines (no imidazoles)...en route to realizing the catalytic promise that ribozymes were supposed to deliver. doi.org/10.1002/cbic.2021006…, @chembiochem, @DNA, @UBCChem
