Andy Stringer (@AndyStringer) header
Andy Stringer (@AndyStringer) profile picture

Andy Stringer

@AndyStringer

Not everything that can be counted counts. Not everything that counts can be counted. (WB Cameron, 1963) Now only on @andystringer.bsky.social

 Pendle, Lancashire
bsky.app/profile/andystringer.bsky.social
Joined June 2011
  • Tweets4.3K
  • Following520
  • Followers272
503Media
Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)Photo by Andy Stringer (@AndyStringer)
The European march before we vote for our national liberation. 🇬🇪🇪🇺 Tbilisi, Georgia. October 20, 2024 #GeVote2024 📷 Giorgi Ebanoidze
Image from Marika Mikiashvili 🇬🇪🇺🇦🇪🇺 (@Mikiashvili_M)
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Nerve injury causes sustained upregulation of α2δ-1 in the DRG, contributing to pain hypersensitivity by directly interacting with and augmenting presynaptic NMDA receptor activity in the spinal dorsal horn. #gabapentanoids #CK2 #HDAC2 #pain jbc.org/article/S0021-9258(2…
Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone...

Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone...

The development of chronic neuropathic pain involves complex synaptic and epigenetic mechanisms. Nerve injury causes sustained upregulation of α2δ-1 (encoded by the Cacna2d1 gene) in the dorsal root...

jbc.org
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Andy Stringer retweeted
Tim Walker (@ThatTimWalker) profile picture
Tim Walker@ThatTimWalker14 Sep 2024
Seldom if ever seen so many EU flags at #LastNightOfTheProms. Anyone would think the country is genuinely sick to death of Brexit.
Image from Tim Walker (@ThatTimWalker)
Image from Tim Walker (@ThatTimWalker)
Image from Tim Walker (@ThatTimWalker)
Image from Tim Walker (@ThatTimWalker)
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Our latest review article explores how SUMOylation & deSUMOylation might hold the key to understanding pain, one ion channel at a time. ✨ Imagine tiny molecular tweaks making a world of difference in chronic pain. 🔍 #SUMOylation #PainResearch link.springer.com/10.1007/s1…
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Wow! I learn something truly fascinating, and often unexpected, every day. Nice use of gold nano-particles.
Dr. Rajesh Khanna of the KhannaLabUF (@KhannaLabUF) profile pictureDr. Rajesh Khanna of the KhannaLabUF@KhannaLabUF8 Sep 2024
HOWZAT!!!! Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system | Science Advances science.org/doi/10.1126/scia…
Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system

Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system

Cerebrospinal fluid unites the nervous system by extending beyond the central nervous system into peripheral nerves.

science.org
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Happy 200th birthday to Anton Bruckner! 🎶🎵🎼🎻 It was a real treat to listen to the Cleveland Orchestra rehearse the 4th symphony outdoors. The concert is tonight but tickets sold out faster than an Oasis concert!
Image of Cleveland Orchestra rehearsing Bruckner's 4th outdoors in Ansfelden on 04Sep2024.

ALT Image of Cleveland Orchestra rehearsing Bruckner's 4th outdoors in Ansfelden on 04Sep2024.

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Excellent article on targeting Nav1.8 in @AmSciMag by @mvbroadfoot scientificamerican.com/artic… Thanks for highlighting @regulonix's and @KhannaLabUF differentiated strategy on Nav1.7.
New Pain Medication Suzetrigine Prevents Pain Signals from Reaching Brain

New Pain Medication Suzetrigine Prevents Pain Signals from Reaching Brain

The medication initially known as VX-548 blocks sodium channels in nerves, blocking pain signals before they reach the brain

scientificamerican.com
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Great music tonight from Jaroslav Šindler Quartet at Jazz Dock in Prague.
Image from Andy Stringer (@AndyStringer)
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Happy #Caturday from Prague.
Image from Andy Stringer (@AndyStringer)
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Andy Stringer retweeted
Rachel Cunliffe (@RMCunliffe) profile picture
Rachel Cunliffe@RMCunliffe9 Aug 2024
Nothing to see here, just the guy who bought Twitter having free speech explained to him by a cat
Image from Rachel Cunliffe (@RMCunliffe)
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Interesting approach with fentanyl derivative RO-76: "targeting water molecules in the sodium binding pocket may be an avenue to modulate signaling properties of opioids, and which may potentially be extended to other GPCRs" #Pain pubs.acs.org/doi/10.1021/acs… pubs.acs.org/doi/10.1021/acs…
Can Targeting the Sodium Site via Water Molecules Lead to the Development of Safer Opioids?

Can Targeting the Sodium Site via Water Molecules Lead to the Development of Safer Opioids?

The μ-opioid receptor (μOR), a member of the G protein-coupled receptor (GPCR) family, continues to be a key target for pain management and opioid use diso

pubs.acs.org
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Here is the final version of @KhannaLabUF's latest paper: Small molecule targeting NaV1.7 via inhibition of... : PAIN journals.lww.com/pain/abstra…
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Andy Stringer retweeted
@mikko (@mikko) profile picture
@mikko
@mikko19 Jul 2024
Too soon?
Image from @mikko (@mikko)
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Sir Lindsay Hoyle, gave us new MPs such a warm welcome at Speaker’s House. His late father, Doug, represented the Nelson & Colne constituency 1974-79, and his father’s first run was actually for Clitheroe in 1964, during which Lindsay delivered leaflets, aged seven!
Image from Jonathan Hinder MP (@Jonathan_Hinder)
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We're looking forward to great things from local lad Jonathan 👍
Jonathan Hinder MP (@Jonathan_Hinder) profile pictureJonathan Hinder MP
@Jonathan_Hinder11 Jul 2024
Officially sworn in 📖 I will be an outspoken champion for Pendle & Clitheroe in Parliament.
Image from Jonathan Hinder MP (@Jonathan_Hinder)
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There’s a clear message for Europe here… Aping or appeasing the far-right only sucks you into them. You have to take it on, putting your own true principles out there in stark opposition to it. It a message for the Tories, for Labour (on immigration & Brexit) and all Europe.
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This is an incredible piece of work by @JonathanPieNews. From the research, to the sequencing, to the performance. You want to know why so many people are turning away from vapid MSM and looking to political comedy & alternative news? Look no further. 👇
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Here's the person to vote for if you want change for the better in Pendle & Clitheroe. 👍
Jonathan Hinder MP (@Jonathan_Hinder) profile pictureJonathan Hinder MP
@Jonathan_Hinder4 Jul 2024
Vote Labour.
Image from Jonathan Hinder MP (@Jonathan_Hinder)
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The polls show it is too close to call between Labour and the Conservatives in Pendle & Clitheroe. No other party is even close here. The choice could not be clearer: more decline under the Conservatives, or change with Labour.
Image from Jonathan Hinder MP (@Jonathan_Hinder)
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