Raghav Ramabadran retweeted
I'm hiring! 🚀
Our Frontier Health team at @GoogleDeepMind is looking for a Research Scientist to build foundational AI & physiological world models for human biology.
Help us transform healthcare from reactive observation to proactive intervention. 🧬
🔗 Apply: goo.gle/3SPNis2
Raghav Ramabadran retweeted
Much of today's AI drug discovery starts with pre-selected targets and known biology.
Our PerturbME starts one step earlier: scaling the discovery of unknown biology and mechanisms.
In this @Genentech × @GoogleDeepMind × @BroadInstitute × @Stanford collaboration, we combine GDM’s Co-Scientist with a sample-efficient, genome-wide, multimodal perturbation framework. This new wet-lab technique allows us to selectively sequence the most informative cancer cells, while Co-Scientist generates mechanistic hypotheses based on, and beyond such data.
These insights could help advance next-generation cancer therapies, including protein binders, mRNA vaccines, and CAR-T cells.
Interested? Preprint (with data and code released) 👇🏻
biorxiv.org/content/10.64898…
Raghav Ramabadran retweeted
For biologists using Claude Science, here is Motif, an AI-native molecular biology workbench plugin. Now, you don't need to leave Claude Science to view and operate on your sequences.
Motif gives the full power of Claude to your upstream mol bio workflows, such as asking Claude to: 1) fetch the genes in a target pathway and annotate them, 2) perform and view multiple sequence alignments using your preferred alignment tool, 3) design and label CRISPR-Cas guide sequences, and much more.
Motif was built as part of the "Built with Claude: Life Sciences" hackathon, and is an MIT-licensed, open source plugin.
Also, Claude made this demo video using HeyGen's Hyperframes and Elevenlabs TTS.
Raghav Ramabadran retweeted
ENVnet provides a global molecular resource of dissolved organic matter nature.com/articles/s41587-0…
Raghav Ramabadran retweeted
Researchers in Science report the development of a general-purpose biomedical AI agent that can help automate biomedical research workflows.
The authors say their results point “toward a future in which AI agents work alongside human researchers to accelerate biomedical discovery from basic research to translation.”
Learn more: scim.ag/3QYElfh
Raghav Ramabadran retweeted
*LOOP ENGINEERING IS A FREE OPEN-SOURCE FRAMEWORK FOR BUILDING SELF-IMPROVING TRADING AGENTS.*
(github.com/cobusgreyling/loo…)
Raghav Ramabadran retweeted
Antibody–bottlebrush conjugates expand the options for drug cargos compared to antibody–drug conjugates go.nature.com/46d1T3t
rdcu.be/fpOS5
Raghav Ramabadran retweeted
A breakthrough in the field of individualized anti-cancer mRNA vaccines: our research, now published in *Nature Biomedical Engineering*, shows that, surprisingly, RNA oligonucleotides lacking a cap and poly-A tail are translated and generate MHC class I epitopes, thereby enabling the induction of specific cytotoxic T cells. Replacing enzymatic production of mRNA by chemical synthesis has several advantages including accelerating the production of individualized mRNA vaccines aimed at inducing anticancer cytotoxic T-cells. nature.com/articles/s41551-0…
Raghav Ramabadran retweeted
new post on harness engineering for AI self-improvement: lilianweng.github.io/posts/2…
It is hard to forecast how much the future of RSI will rely on harnesses. Likely harness engineering will evolve in the direction of self-improvement and enable auto-research, and, in turn, smarter models keeps harnesses simple.
Even when many harness improvement get eventually internalized into core model, the need to specify goals and context will not disappear.
Raghav Ramabadran retweeted
For readers interested in therapeutic epigenetic editing, which aims to reprogramme gene expression by rewriting epigenetic signatures without editing of the genome, here's a comprehensive review nature.com/articles/s41573-0…
rdcu.be/fsCoc
Raghav Ramabadran retweeted
An artificial neural network built into a computer memory chip reconstructs the human cortex with high accuracy in real time.
Learn more in a new #SciencePerspective: scim.ag/4eLCqDQ
Raghav Ramabadran retweeted
Introducing ATHENA: an AI agent for treatment reasoning across all FDA approved drugs since 1939, by stellar @GaoShanghua
Paper: arxiv.org/abs/2606.28692
Code: github.com/mims-harvard/ATHE…
Project: athena.openscientist.ai
Every treatment decision means weighing disease context, comorbidities, drug interactions, contraindications, and evidence that keeps changing. That is an iterative reasoning problem. You have to figure out what evidence to go find before you can even start forming a conclusion.
Most LLMs answer from what is stored in their weights. Give agents tools and they often still do not use them well. Having access to a biomedical database does not automatically mean a model knows when to query it, what to ask, or how to weigh what comes back.
Raghav Ramabadran retweeted
Microsoft made ChatGPT's accuracy jump from 41% to 80% without touching a single parameter.
The system is called SkillOpt.
Most people think AI agents improve by writing better prompts or fine-tuning the model itself. But fine-tuning is rigid, slow, and expensive. And "prompt engineering" is just guessing.
Microsoft’s approach treats the AI’s skill set, the actual text document that tells it how to solve a problem, as a living, breathing model that learns from its own failures.
Here is how it works:
1. Rollouts: The agent attempts tasks. It captures its own successes and failures.
2. Optimizer Model: A separate, small model analyzes those results and makes atomic edits to the skill document (Add, Delete, or Replace).
3. Validation Gate: The new skill is only "accepted" if it strictly improves performance on a held-out set of tasks.
It is essentially "Gradient Descent" for natural language.
And the results are staggering:
Across six major benchmarks, SkillOpt outperformed every human-written skill and every one-shot LLM approach.
On some tasks, accuracy skyrocketed. On the ALFWorld benchmark, one model jumped from 70% to 85% accuracy. In direct chat scenarios, it boosted accuracy by over 23 points.
The best part?
There is zero inference-time overhead.
You spend the compute optimizing the skill once. Then, the agent runs with that hyper-optimized playbook forever.
The playbook effectively "trains" itself through feedback.
If you want an agent that actually gets better at its job every single day, without you having to touch a single line of code, this is how it’s done.
Raghav Ramabadran retweeted
Frontier AI companies as biotech acquirers nature.com/articles/s41587-0…
Raghav Ramabadran retweeted
‼️ BREAKING: Anthropic has embedded hidden spyware-like code in Claude Code that covertly targets Chinese users. It then sends information regarding every user by injecting it into their prompt message.
Claude Code is sending info like timezone, proxy and possible AI Lab connections into the system prompt in ways Chinese users can't notice.
A coding agent with repo and command permissions should not silently hide routing metadata inside prompts. This is a serious breach of user trust.
Raghav Ramabadran retweeted
Researchers show that Claude Code is 98% not AI.
Anthropic never gave us the architecture for Claude Code. There were no docs. Just a tool that every developer is currently obsessing over.
Until it leaked recently.
A research team pulled the source code, analyzed all 500,000 lines, and found something ridiculous.
Only 1.6% of the codebase actually interacts with the AI model.
The core of Claude Code is literally just a simple while-loop. It asks the model what to do, runs a tool, and repeats.
So what is the other 98.4%?
It is hardcore, traditional software engineering.
The researchers found a massive, complex infrastructure designed entirely to babysit the AI and keep it from hallucinating or destroying your computer:
- A 7-mode permission system acting as a security bouncer.
- A 5-layer context compaction pipeline so the AI doesn't forget its goal.
- A subagent delegation mechanism with strict worktree isolation.
- Four different extensibility hooks to manage external tools safely.
Every startup right now is trying to build a better AI model to get better results.
Anthropic did the exact opposite.
They took an existing model and built a fortress of deterministic software around it.
They realized that the AI doesn't need to be smarter. It needs to be managed.
Raghav Ramabadran retweeted
Novel drug targets in 2025
nature.com/articles/d41573-0…
This new article highlights 11 targets not previously modulated by approved drugs
Raghav Ramabadran retweeted
a really concise and cool blog on the current landscape of robotics i found recently and finished reading just now : interlatent.com/blog/interla…
Raghav Ramabadran retweeted
Building autonomous agents for scientific discovery? 🧬🤖
@GoogleDeepMind Science Skills is now available on GitHub. We've open-sourced this specialized toolkit to accelerate your agentic workflows with scientific grounding and higher token efficiency.
Download now ↓
github.com/google-deepmind/s…
Raghav Ramabadran retweeted
Just published @NEJM
Marked and durable reduction of LDL cholesterol with one shot PCSK9 gene base editing @skathire nejm.org/doi/full/10.1056/NE…






























