BrainOrganoid (@BOrganoid) profile picture

BrainOrganoid

@BOrganoid

A group of neuroscientists trying to recreate the human brain in a dish. @BrainOrganoid

Joined December 2018
  • Tweets720
  • Following158
  • Followers829
BrainOrganoid retweeted
Hugo Chrost (@chrost_hugo) profile picture
Hugo Chrost
@chrost_hugo24 Sep 2023
The projecting axons of neurons (red) from a human brain organoid grow out across a culture dish. Their nuclei are stained blue. Credits: Alysson Muotri #MedTwitter
Image from Hugo Chrost (@chrost_hugo)
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The @Knoblich_lab and the @TreutleinLab show that perturbation of 36 high-risk #autism spectrum disorder genes 🧬related to transcriptional regulation uncovers their effects on cell fate determination. 🎉 Congratulations to the team on their study! go.nature.com/488AuA5
Image from Organoid News (@organoidscience)
Image from Organoid News (@organoidscience)
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BrainOrganoid retweeted
cedric boeckx (@cedricboeckx) profile picture
cedric boeckx@cedricboeckx4 Aug 2023
Very interesting #PAX6 cerebral #organoid work by @cwkcalvin @johnomason and colleagues, uncovering phenotypic properties not previously observed based on mouse models 🧫🧠🧬: biorxiv.org/content/10.1101/…
Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

The transcription factor PAX6 is a crucial regulator of multiple aspects of embryonic forebrain development. Its well-known roles in mice include regulating differentiation of excitatory and inhibi...

biorxiv.org
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BrainOrganoid retweeted
Molecule (@Molecule_sci) profile picture
Molecule
@Molecule_sci16 Jun 2023
Plus, it’ll also provide information about what will happen to our brains if we all decide to migrate to Mars! Thanks Dr Alysson Muotri & @UCSanDiego ! the-scientist.com/scientist-…
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A new preprint suggests postmortem brains are a poor stand-in for living brains in studies of neurological conditions, including autism, though several scientists disagree. spectrumnews.org/news/prepri…
Preprint questions validity of postmortem brain studies

Preprint questions validity of postmortem brain studies

But the alternatives, including living-brain biopsies, raise logistical and ethical questions, experts say.

thetransmitter.org
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🚨New Research Topic🚨 We are excited to announce a new Research Topic on Developmental Brain Diseases Through the Lens of iPS Cells and Organoids Led by Drs. Gabriel G Haddad, Alysson Renato Muotri and Fred H Gage ➡️ Learn more here: fro.ntiers.in/sMHZ
Image from Frontiers - Neuroscience (@FrontNeurosci)
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Philipp Wörsdörfer (@woephi) and colleagues describe a novel neuro-#mesodermal #assembloid model that recapitulates aspects of peripheral nervous system development, such as #NeuralCrest cell induction, and much more! 📖 Full study in @stemcellreports: bit.ly/43LJ6u2
Image from Organoid News (@organoidscience)
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In a new theory of embodied consciousness, neuroscientists Antonio Damasio & Hanna Damasio propose that feelings are the source of consciousness. W/o them, consciousness is impossible–w/radical implications for the ‘hard problem’ of consciousness & ... AI iai.tv/articles/consciousnes…
Consciousness begins with feeling, not thinking

Consciousness begins with feeling, not thinking

Forget ‘I think therefore I am’. In a new theory of embodied consciousness, the neuroscientists Antonio Damasio and Hanna Damasio propose that feelings are the source of consciousness. Long dismissed...

iai.tv
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BrainOrganoid retweeted
Elon Musk (@elonmusk) profile picture
Elon Musk
@elonmusk20 Apr 2023
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Why do we still have journals when we can publish our work on the internet, open access, with post publication review and discussion?
Imaging Neuroscience (@ImagingNeurosci) profile pictureImaging Neuroscience@ImagingNeurosci17 Apr 2023
All NeuroImage and NeuroImage:Reports editors have resigned over the high publication fee, and are starting a new non-profit journal imaging-neuroscience.org This comes with great regret, and a huge amount of thought and discussion- please read announcement to get more details.
Image from Imaging Neuroscience (@ImagingNeurosci)
Image from Imaging Neuroscience (@ImagingNeurosci)
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BrainOrganoid retweeted
Inhyun Park (@Inhyun_P) profile picture
Inhyun Park@Inhyun_P4 Apr 2023
Excellent work by @Kiral_Ridvan, @bilal_cakirr, @Yangfei_Lab, and @lab_tanaka is finally out at @CellStemCell to generate ventrally fated human thalamic organoids. cell.com/cell-stem-cell/full…
Generation of ventralized human thalamic organoids with thalamic reticular nucleus

Generation of ventralized human thalamic organoids with thalamic reticular nucleus

Generation of organoid models for subregions of the human brain is challenging. Park and colleagues report a method to generate ventralized thalamic organoids, which recapitulate molecular and...

cell.com
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Too delicate a topic? This very well written and most comprehensive take on human brain organoid ethics was rejected by many journals! Congrats to Meagan and team for persisting! @PittNeurosurg @BOrganoid @UPMCHillmanCC @AHabibMD
This Post is from an account that no longer exists. Learn more
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Important new review on "embodied mind". Buzsáki and Tingley: cognition from allostasis. annualreviews.org/doi/abs/10…
Image from peter sterling (@whatishealth21)
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Debunking another bullshit paper on Neanderthals coauthored by a newly minted @NobelPrize winner. Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals” science.org/doi/10.1126/scie…
Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than...

Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than...

Pinson et al. (1) concluded that the modern human TKTL1 gene is responsible for an increased number of cortical neurons. We show that the “putative Neanderthal variant” of TKTL1 is present in modern...

science.org
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Interesting piece. 2 of 3 scientists mentioned, Muotri & Hanna, are among the most controversial in the area. (Matt Porteus, the 3rd, isn't.) Surprised it didn't mention the NASEM report on this topic, issued in April 2021. Also surprised I hadn't heard about the meeting.
Timothy Caulfield (@CaulfieldTim) profile pictureTimothy Caulfield
@CaulfieldTim13 Feb 2023
Ethics of cutting-edge stem cell research statnews.com/2023/02/13/scie… by @JonathanWosen @statnews “I’m worried about the Silicon Valley tech bro, who decides that they’re smarter than the world & they’re going to do something that maybe the rest of us don’t believe is appropriate.”
‘It is a balance’: Scientists grapple with ethics of cutting-edge stem cell research

‘It is a balance’: Scientists grapple with ethics of cutting-edge stem cell research

Stem cell scientists cautioned that focusing on the potential misuse of their work, rather than the good that can come from it, could be counterproductive.

statnews.com
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Don’t conference organizers ever get tired of seeing the same talks by the same people at every conference?
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Most brain-imaging studies make 3 questionable assumptions: mental events are localizable, map uniquely to dedicated #brain circuitry, & are independent of larger context. These 19th-century views need an update. New #OpenAccess paper in @TrendsCognSci. 1/ cell.com/trends/cognitive-sc…
Improving the study of brain-behavior relationships by revisiting basic assumptions

Improving the study of brain-behavior relationships by revisiting basic assumptions

Most brain imaging studies present stimuli and measure behavioral responses in temporal units (trials) that are ordered randomly. Participants’ brain signals are typically aggregated to model...

cell.com
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BrainOrganoid retweeted
Luiz Pessoa (@PessoaBrain) profile picture
Luiz Pessoa@PessoaBrain22 Jan 2023
Interesting piece on the origins of optogenetics. statnews.com/2016/09/01/opto…
He may have invented one of neuroscience’s biggest advances. But you’ve never heard of him

He may have invented one of neuroscience’s biggest advances. But you’ve never heard of him

The saga of Zhuo-Hua Pan, perhaps the rightful inventor of optogenetics, raises the question of what it means to invent something in science.

statnews.com
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BrainOrganoid retweeted
John Hawks (@johnhawks) profile picture
John Hawks
@johnhawks12 Jan 2023
A lot of study of human brain evolution has gone off on the wrong track by thinking about encephalization (big brain size) as a problem for the rest of our biology to solve, instead of working out the functions of encephalization. Big brains aren't magical problem-solvers!
Anatomical model of a brain. Photo: Photo: Robina Weermeijer, Unsplash

ALT Anatomical model of a brain. Photo: Photo: Robina Weermeijer, Unsplash

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