@ColmJJORourke

Translational (epi)genomics in chemoresistance & metastasis of hepatobiliary cancers.

Joined November 2019
  • Tweets4.7K
  • Following544
  • Followers552
3Media
Colm O'Rourke retweeted
Dr Amol Akhade
@SuyogCancerOct 24
ESMO 2026 presidential 2 | HARMONi-GI1: Ivonescimab beats durvalumab in advanced biliary tract cancer! Phase III trial (n=682): Ivonescimab (PD-1/VEGF bispecific antibody) + gemcitabine/cisplatin vs durvalumab + gemcitabine/cisplatin in 1L advanced BTC. 📊 Key results: ✅ Median OS: 14.9 vs 12.1 months (HR 0.75; p=0.0031) ✅ Median PFS: 8.4 vs 5.8 months (HR 0.61; p<0.0001) ✅ ORR: 53.8% vs 32.5% (p<0.0001) ✅ Manageable safety profile; no new safety signals. 🔥 25% reduction in risk of death and 39% reduction in risk of progression! A rare head-to-head phase III victory against an established immunotherapy standard in BTC. Could PD-1/VEGF bispecific antibodies replace conventional PD-L1 inhibition in first-line BTC? @OncoAlert @myESMO #ESMO26 #BiliaryTractCancer #Oncology
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Colm O'Rourke retweeted
Paul Howard@AkaPaulHowardOct 23
Absolutely delighted that A Nation Once Again has been shortlisted for an @IrishBookAward in the Best Popular Fiction category. If you enjoyed it, you can vote for it or any other books you might have enjoyed here. irishbookawards.ie/vote/
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Colm O'Rourke retweeted
CONSEQUENCE
@consequenceOct 23
David Byrne predicts AI is "not going to end well." "I've read enough science fiction." consequence.net/2026/10/davi…

David Byrne Believes AI Is "Not Going to End Well"

David Byrne has shared his bleak outlook on artificial intelligence in a new interview, during which he also discussed nostalgia, creativity, and his latest book.

consequence.net
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Colm O'Rourke retweeted
CONSEQUENCE
@consequenceOct 22
LEGO has announced an official partnership with Daft Punk. The collab will kick off with a brand-new official set based on their iconic 2007 ALIVE pyramid stage.
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Colm O'Rourke retweeted
Dr. Thomas Ichim
@exosomeOct 20
Nature paper... CANCER is evil...it prepares distant organs for metastasis BEFORE tumor cells arrive Suppressive myeloid cells helped build lung premetastatic niches. Epigenetic therapy disrupted this process and reduced metastases nature.com/articles/s41586-0…

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Nature - In mouse models of pulmonary metastasis, adjuvant epigenetic therapy targeting myeloid-derived suppressor cells disrupts the premetastatic microenvironment after resection of primary...

nature.com
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Colm O'Rourke retweeted
The Tonight Show
@FallonTonightOct 20
.@jomcnally has no hobbies 😭 #FallonTonight #StandUp
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Colm O'Rourke retweeted
Ben Stiller
@BenStillerOct 17
Title sequence for Crystal Lake is incredible.
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Colm O'Rourke retweeted
Ryanair
@RyanairOct 16
you're hired
Windy hell@windy_hellOct 15
Michael O'Leary, CEO of the low-cost airline Ryanair, came to the Irish pub. The guys did not lose their heads and added an additional fee to the receipt for a footrest, a quiet area and a priority landing.
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Published today in Nature Genetics, our lab research team reveals how pancreatic cancer cells shift between subtypes and adapt within tumors. These insights could help advance more effective treatments for patients. bit.ly/4hGTpJ0
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Colm O'Rourke retweeted
Cancer Cell@Cancer_CellOct 12
Tumor cells recruit macrophage bodyguards to outlast chemotherapy dlvr.​it/TVthhD
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Colm O'Rourke retweeted
Ed Reznik@EdReznikOct 12
After many years of effort, deliberation, excitement, angst, joy, and Wednesday afternoon lab lunches, our group's first manuscript on cachexia, led by Venise Jan Castillon, Amy Xie, and really our whole lab nature.com/articles/s41591-0… @NatureMedicine

A health-system-scale, episode-resolved multimodal atlas of cancer cachexia

Nature Medicine - Using longitudinal data from 52,236 patients with cancer, this study created a multimodal atlas of cancer cachexia, demonstrating that weight loss episodes are linked to systemic...

nature.com
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Colm O'Rourke retweeted
Marcus Goncalves
@MarcusDGonOct 12
Out now in Nature Medicine: a health-system-scale cachexia atlas (52K patients) that describes and predicts outcomes, with prospective risk models for lung, colorectal, and prostate cancer. Congrats to @EdReznik for a landmark paper for the field. nature.com/articles/s41591-0…

A health-system-scale, episode-resolved multimodal atlas of cancer cachexia

Nature Medicine - Using longitudinal data from 52,236 patients with cancer, this study created a multimodal atlas of cancer cachexia, demonstrating that weight loss episodes are linked to systemic...

nature.com
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Fontaines D.C. 'Dopamine Chamber' review: Dystopia has never sounded so glorious rollingstone.co.uk/music/fon…

Fontaines D.C. 'Dopamine Chamber' review: Dystopia has never sounded so glorious

After the surreal technicolour dreams of 'Romance', Fontaines D.C. have landed back on Earth to dissect our fractured reality. The result is something truly special.

rollingstone.co.uk
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You’ve waited long enough… 🕛 Be among the first to know: blondie.lnk.to/blondiesignup…
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The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact innovationsjournals-jipo.kgl…

The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact

Readers can claim CME credit for reading this article via InnoScholar. For complete details, visit innoscholar.com/course/jipo-cme-immune-checkpoint-inhibitors-journey/ ABSTRACT Immune checkpoint...

innovationsjournals-jipo.kglmeridian.com
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Colm O'Rourke retweeted
Waggoner Lab@LabWaggonerOct 6
STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therapy @CellCellPress cell.com/cell/fulltext/S0092… 🇨🇳
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Colm O'Rourke retweeted
Joe Sabatino@jsabatino37Oct 6
T cell immunomonitoring: a comparative analysis of traditional and novel methods to quantify and characterize human antigen-specific T cells nature.com/articles/s41596-0…

T cell immunomonitoring: a comparative analysis of traditional and novel methods to quantify and...

Nature Protocols - We present a comparative analysis review of traditional and cutting-edge technologies for clinical profiling of antigen-specific T cells, highlighting their principles,...

nature.com
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New online! Exploring the immunological effects of antibody–drug conjugates dlvr.​it/TVp8pR
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Colm O'Rourke retweeted
gilberto lopes
@GlopesMdOct 5
One in eight cancers worldwide was attributable to infections in 2024. A new Lancet Oncology / IARC analysis estimates 2.3 million cases — about 12% of all new cancers globally.
Miami-style infographic summarizing a Lancet Oncology and IARC global analysis estimating 2.3 million infection-attributable cancer cases in 2024, about 12% of all new cancers worldwide, with the largest burdens from H. pylori, HPV, HBV, EBV, and HCV.

ALT Miami-style infographic summarizing a Lancet Oncology and IARC global analysis estimating 2.3 million infection-attributable cancer cases in 2024, about 12% of all new cancers worldwide, with the largest burdens from H. pylori, HPV, HBV, EBV, and HCV.

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Colm O'Rourke retweeted
Dr. Thomas Ichim
@exosomeOct 6
Checkpoint inhibitor immunotherapy works best in the morning...because myeloid suppressor cells are most active in the evening... nature.com/articles/s41590-0…

Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade

Nature Immunology - Immunosuppression is regulated by the circadian clock and can be leveraged to promote the efficacy of immune checkpoint inhibitor therapy.

nature.com
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