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Hill Lab

@Geoff_Hill_Lab

Hill Lab (run by lab members) @FredHutch #BMT #GVHD #immunotherapy #myeloma

 Fred Hutchinson
research.fhcrc.org/geoff-hill/en/research-overview.html
Joined February 2020
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  • Followers109
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Photo by Hill Lab (@Geoff_Hill_Lab)Photo by Hill Lab (@Geoff_Hill_Lab)
Eomes controls the acquisition of regulatory and cytotoxic function in CD4+ T cells that are critical for limiting immune toxicity, while maintaining persistence and tumor control after immunotherapy @ImmunityCP cell.com/immunity/fulltext/S… @fredhutch @Geoff_Hill_Lab 🇺🇸
Image from Waggoner Lab (@LabWaggoner)
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Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin | NEJM

Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin | NEJM

Allogeneic peripheral-blood stem-cell transplantation (SCT) from a matched related donor after myeloablative conditioning is the preferred curative treatment for patients with high-risk blood cance...

nejm.org
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I’m excited to share what has been 5 years in the making (my first project in the lab starting as a heme/onc fellow)! Microbiota dictate T cell clonal selection to augment graft-vs-host-disease following stem cell transplant. @ImmunityCP @Geoff_Hill_Lab cell.com/immunity/fulltext/S…
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Treg depletion during SCM expands polyfunctional effector T cells in mobilized grafts and enhances antimyeloma immunity after ASCT. ow.ly/syjV50RjakL #transplantation #immunobiologyandimmunotherapy
Image from Blood Journals Portfolio (@BloodPortfolio)
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For open access to our recent manuscript describing T cells that retained functional capacity despite a terminally exhausted phenotype, visit the Hill Lab webpage via the link below and scroll down to the myeloma section! research.fredhutch.org/geoff…

Research Overview

Research overview of Dr. Geoffrey Hill's lab at Fred Hutch Cancer Center.

research.fredhutch.org
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My fave postdoc project is out today!! This manuscript has been a labor of love and I'm so excited to finally share it with the broader immunology community. science.org/doi/10.1126/scii…
TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematologi...

TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematologi...

A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow.

science.org
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Next paper out of the @Geoff_Hill_Lab!! Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation ashpublications.org/blood/ar…
Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and...

Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and...

T cells from bone marrow egress to blood during SCM and preferentially home back to marrow after adoptive transfer.Treg depletion during SCM expands polyfu

ashpublications.org
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When the autograft team hears the boss has a penchant for band T-shirts…. – at Seattle, WA
Image from Simone Minnie (@simone_minnie)
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In new work published in @SciImmunology, Drs. @simone_minnie and Geoff Hill show that by directing immune stimulation at the right group of cells, they can prevent #leukemia and #myeloma relapse after #bonemarrowtransplant without exacerbating #GVHD. bit.ly/3TnBTuh
New approach could make bone marrow transplantation safer, stronger

New approach could make bone marrow transplantation safer, stronger

A Fred Hutchinson Cancer Center team has developed a strategy that could improve the effects of bone marrow transplantation for blood cancer while minimizing GHVD. Laboratory models of leukemia and...

fredhutch.org
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Agonist #immunotherapy with engineered IL-18 following allogeneic bone marrow transplant in mice improved anti-tumor activity without increasing the chance of graft-versus-host onset. @fredhutch @MonashUni @simone_minnie @Geoff_Hill_Lab scim.ag/bY
Image from Science Immunology (@SciImmunology)
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CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant loom.ly/0EL7W_E
Image from Blood Journals Portfolio (@BloodPortfolio)
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Still time to apply! The Hill lab is looking for a postdoc to work on Immunotherapy/CAR T cell projects. Message me if you have any Q's about working in the lab etc. FHCRC has great visa support as well! social.icims.com/viewjob/pt1…
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I’ll be presenting two of our #immunotherapy for #myeloma projects. One oral presentation on the combination of TIGIT and lenalidomide (Sat 4:45pm) and a poster on an IL-2/IL-15 mimetic (NL201) on Sat as well!
ASH (@ASH_hematology) profile pictureASH
@ASH_hematology4 Nov 2021
#ASH21 abstracts are now live! Click here: loom.ly/U7wx2-w What abstracts are you most excited about? 🤩 Tells us via quote retweets or replies!
Image from ASH (@ASH_hematology)
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Outstanding talk about T cell differentiation and exhaustion of myeloma specific T cells in murine models. By @simone_minnie of Geoff Hill’s lab at @fredhutch at @RHsct2. – at Manhattan, NY
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Fred Hutch's #Immunotherapy Integrated Research Center (IIRC) is accepting applications for a faculty position in #cancer #immunology. Learn more and apply: apply.interfolio.com/94679 #CareersStartHere @FH_IRC
Image from Fred Hutch Cancer Center (@fredhutch)
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CMV exposure in SCT donors leaves a lasting immunological impression. @AlbertCYeh & @Geoff_Hill_Lab, Clinical Research Division @fredhutch, find new links between a CMV-specific memory CD4+ T cell subset and poor stem cell transplant outcomes. Read more: fredhutch.org/en/news/spotli…
A lasting impression: CMV exposure imprints donor T cell phenotypes

A lasting impression: CMV exposure imprints donor T cell phenotypes

Linking a new CMV-specific cytolytic memory CD4+ T cell subset to impaired immunity and survival in stem cell transplant recipients.

fredhutch.org
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Now recruiting members of my new lab! Excited to build a team at the Fred Hutch, starting this fall. #microbiome #BMT #immunology social.icims.com/viewjob/pt1…
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Our perspective on mechanisms of action of ASCT for myeloma is out! frontiersin.org/articles/10.…

Frontiers | Autologous Stem Cell Transplantation for Myeloma: Cytoreduction or an Immunotherapy?

The incidence of multiple myeloma (MM), a bone marrow (BM) resident hematological malignancy, is increasing globally. The disease has substantial morbidity a...

frontiersin.org
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Check out this latest podcast with @ASH_hematology where we discuss the importance of gut microbes in allogeneic bone marrow transplantation together with Dr Jonathan Peled #mskcc @DrMvandenBrink @NEJM @BloodJournal soundcloud.com/ash_hematolog…
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Replying to @simone_minnie
@simone_minnie describing TIGIT as an excellent target post autoHCT in #myeloma #TCTM20
Image from Michael Tees MD, MPH (@MikeTeesMD)
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