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Our lab studies the mechanisms of thymic T-cell tolerance. We develop innovative strategies to regenerate the thymic function and treat autoimmune diseases.

CIML Marseille France
Joined February 2022
Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)Photo by Magali IRLA Lab (@IrlaLab)
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Thrilled to share that our review in @ScienceAdvances is out!🧬We highlight how age-related thymic involution alters T-cell immunity and discuss therapeutic strategies to rejuvenate thymic function and promote healthier aging. #immunology #Aging #thymus science.org/doi/10.1126/scia…
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Having a great time with the team ! #immunology #CIML
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Magali IRLA Lab retweeted
Replying to @IrlaLab
@IrlaLab and collaborators reveals that RANKL therapy reverses age-related thymic decline, recovering immune health in older adults by restoring youthful T-cell responses to vaccines and tumors. Check their study in @ScienceTM. science.org/doi/10.1126/scit…
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New work connects #immunosenescence and the decline of the #thymus during aging with a drop in the ligand #RANKL—and shows RANKL treatment restores T cell production and rejuvenates immune responses in aged mice. @IrlaLab @JrmyCSantamaria @CIML_Immunology scim.ag/3ZAqihe
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We provide the proof-of-concept that RANKL stimulates human endothelial and epithelial cells using thymic organo-cultures, providing an exciting new therapeutic approach in the arsenal of regenerative medicine to rejuvenate the immune system.
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This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice.
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RANKL treatment in aged mice restores thymic architecture as well as cellularity and functional properties of endothelial and epithelial cells. This boosted T-cell production in the aged thymus.
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We demonstrate that the RANK-RANKL axis in the thymus is altered during aging. In addition to thymic epithelial cells, endothelial cells depend on RANK signaling for their cellularity and functional maturation.
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Magali IRLA Lab retweeted
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. science.org/doi/10.1126/scit… @ScienceTM
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Congrats to @AlexiaBorelli for successfully defending her PhD thesis at @CIML_Immunology ! Her work has advanced our understanding of Foxp3+ Treg development and thymic recirculation, with 2 first-author papers in @NatureComms and Cell Mol Life Sci. #Treg #Thymus #Immuno #CIML
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Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk A recent study has found that vitamin D deficiency during childhood accelerates the aging of the thymus, an organ essential for developing a healthy immune system. The thymus helps train immune cells to distinguish between the body’s own tissues and harmful invaders, but when it ages prematurely due to a lack of vitamin D, it becomes less effective. This increases the risk of autoimmune diseases like type 1 diabetes, as the immune system may mistakenly attack healthy tissues. The research underscores the importance of adequate vitamin D intake, particularly during "vitamin D winter" when sunlight is insufficient for natural production. Ensuring children receive proper vitamin D supplementation during these months could help prevent autoimmune disorders.
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Review by Pala et al. highlights how novel cutting-edge technologies, incl. high-resolution imaging, single-cell omics & organoid cultures, have improved our understanding of human #thymus biology hubs.la/Q02TfwHP0 📘In our #Autoimmunity collection: hubs.la/Q02TfzFt0
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Magali IRLA Lab retweeted
New issue online! This beautiful cover depicts work from @maxim_artyomov, Pavla Bohacova, Marina Terekhova &co identifying CD38 expression as a marker of recent thymic emigrants. Image credit: Fishy Frog cell.com/immunity/issue?pii=…
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