JNap retweeted
There is no fact-based argument for a reduction of data center build out due to an already expected split government midterm result or the state voting initiatives.
1. If a local/state gov doesn’t want to make a deal, the cloud/hyperscaler will move to one who will . This isn’t binary, most locals are making deals. The builds over the next 1-1.5yrs are already permitted.
2. If the US as a whole rejects enough land mass where the demand for AI factories cannot be fulfilled in the US, those AI factories will move offshore repeating the prior 3 decades of globalization and hollowing out of our middle class. It was dumb back then and even dumber now given the geopolitical national security implications of AI sovereignty…
@HalftimeReport @TheJudgeCNBC
JNap retweeted
Long thesis on Rezolute $RZLT —> Market still discounting ersodetug since the failed Ph3 sunRIZE trial, despite subsequent clinical + regulatory developments that have substantially improved the outlook for both THI & CHI.
The registrational Ph3 upLIFT study in THI showed 7 responders among the first 8 patients. They need just just 2 additional responders among the remaining 8 to meet the prespecified efficacy threshold. That creates a ~96% probability of primary-endpoint success. (Magnitude of the final response and FDA’s acceptance of the small single-arm dataset are remaining uncertainties.)
Also, CHI indication isn’t totally dead yet. The FDA recommendation (10/5/26) to proceed toward a pre-BLA meeting for CHI revives the indication which has been written off entirely by the market. Although approval is still uncertain, the FDA’s willingness to entertain a BLA based on the totality of evidence substantially reduces the likelihood of an immediate repeat Ph3 req.
2 potentially registrational indications, improving regulatory visibility, and current valuation that arguably fails to reflect the combined franchise opportunity (and elevated short interest). Asymmetric setup ahead of the THI readout and subsequent BLA discussions on CHI.
JNap retweeted
BREAKING - KISS cofounder Gene Simmons says it is time for celebrities like Ben Stiller and Mark Ruffalo to “shut the f*ck up.”
“People work hard for a living, and they don’t want to be lectured by people who live in mansions and drive Rolls-Royces. It’s time to shut up.”
JNap retweeted
September 3rd, 2021: Virginia Tech runs out to Enter Sandman to a full crowd after COVID before an upset win over #10 UNC #Hokies
JNap retweeted
My committee combed through millions of COVID documents, and what did we find?
Anthony Fauci destroyed records. He told others to delete emails. And then he told them to delete them from deleted files.
He and his allies privately doubted the "implausible" line on a lab leak while publicly attacking anyone who raised it.
And he never took responsibility for funding dangerous research in China.
Next week, Dr. Fauci goes under oath in front of my committee, and he’s going to answer for everything we’ve found.
JNap retweeted
Everyone's sick of $ABVX but I'm jumping on the bandwagon here. Full thoughts on Substack.
Mgmt did damage their credibility, and should have realised how the market would react when they pride themselves on being a 'safe oral alternative' when they have no good explanation prepped.
Irregardless, they have a phenomenal drug on their hands, the cases aren't screaming causality, and the MoA doesn't naturally add up to cancer induction ; especially in that timeline.
Will wait for the next couple weeks for the full safety package, and ABTECT maintenance part 2 in induction non-responders, which should show another 150 patients on 50mg for 44weeks (and how clean it is).
I don't think it's a bad entry here to be honest, and BP could probably ask for $150 here, and get CD for basically nothing here.
Full Thoughts: open.substack.com/pub/hanseo…
