Yasar Arfat T Kasu retweeted
Ribosomes take a break from their usual role go.nature.com/4bV9NAl
Yasar Arfat T Kasu retweeted
Can anti-aging antibodies revive the immune system? In @NatureNV we previewed the latest breakthrough from Irv Weissman's team in @Nature that used immunotherapy to deplete aging stem cells. @KasuYasar nature.com/articles/d41586-0…
Yasar Arfat T Kasu retweeted
🆕 @Nature
Rejuvenating the aged immune system with antibody depletion of blood myeloid stem cells @justsaysinmice
nature.com/articles/s41586-0…
nature.com/articles/d41586-0…
@HOSTvsVirus @SignerLab @KasuYasar
Big implications
Yasar Arfat T Kasu retweeted
Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1
Yasar Arfat T Kasu retweeted
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Yasar Arfat T Kasu retweeted
Out now! Unveiling the mystery of TRiC/CCT chaperonin assembly! 🥳Our paper uncovers how its unique double-ring architecture forms through a step-by-step hierarchy. Many congrats to the first authors @mirandacollier @KarenBetaMor! 😍
Check out more here:
sciencedirect.com/science/ar…
Yasar Arfat T Kasu retweeted
Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3
Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.
Congratulations, India🇮🇳!
#Chandrayaan_3
#Ch3
Yasar Arfat T Kasu retweeted
A mind-blowing paper has come out today in @Nature
In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/scie…).
Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.
The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.
Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.
When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.
The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.
The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:
“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (scienmag.com/artificial-cell…)
nature.com/articles/s41586-0…
Yasar Arfat T Kasu retweeted
Ribo-ITP enables ribosome occupancy measurements from single cells. Our first application revealed insights into allele-specific ribosome engagement in early development (nature.com/articles/s41586-0…). #RiboITP #singlecell
Yasar Arfat T Kasu retweeted
Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
Cell
cell.com/cell/fulltext/S0092…
Yasar Arfat T Kasu retweeted
Happy to be part of this fun collaboration with Nick Baker- in this study led by @FolgadoVirginia and Kristina Ames we show that the ribosomal protein RpS12 is required for skeletal development and hematopoiesis in mice doi.org/10.7554/eLife.69322
Yasar Arfat T Kasu retweeted
For 50 years we've known that recycling helps keep our planet healthy. Now we know it's also essential to boost stem cell fitness & longevity.
New in @CellStemCell, the @SignerLab finds blood stem cells have an unexpected way of taking out their trash. This protein recycling pathway could be the key to maintaining longterm health and preventing age-related blood and immune disorders @ucsdstemcell
today.ucsd.edu/story/to-ward…
Yasar Arfat T Kasu retweeted
Breakdown of PhD student cost on a grant:
tuition $45K
stipend $35K
fringe $10K
indirects $60K
--
total paid by NIH to university: $150K
total paid by university to student: $35K
(this is just a toy example to illustrate a point, not real numbers but same ballpark)
Yasar Arfat T Kasu retweeted
I have been in university setups for 20 yrs, from UG until now. Never in those many yrs, I have seen a strike/protest organized by the faculty demanding a change to status quo. Never. Not once. That is one of the reasons why we're in this "poorly paid ECRs" situation in academia.
Yasar Arfat T Kasu retweeted
Happening now! UCSD picket line is surrounding the faculty club. We are told Chancellor Khosla is inside.
#FairUCNow #UAWonStrike #UCstrike
Yasar Arfat T Kasu retweeted
Several members of the UCSD PDA are in support of the Academic Worker strike at the University of California and show their solidarity for #FairContractNow.
See our statement attached,
@UAW5810
@uaw2865
@sruuaw
ALT We, several board members of the UC San Diego Postdoctoral Association, state our full support for the historic unfair labor practice strike of UAW Academic Student Employees, Academic Researchers, Postdocs and Student Researchers. It is long overdue that these academic workers receive fair compensation, secure working conditions, and adequate benefits. We believe everyone should be paid enough to live a decent life, have a roof on top of their head, and food on their table. We support the fight for basic human rights such as living wages, maternity leave for all employees, subsidized child care, protection from bullying and harassment, subsidized public transport, and visa support for international scholars. Together, we urge the University of California to negotiate in good faith to ensure a fair contract, prioritizing its employees' wellbeing and success. Without good faith bargaining and a fair contract, the UC system will continue to lose talented scholars and fail to meet equity.
Yasar Arfat T Kasu retweeted
BREAKING: 48,000 academic workers at the University of California have begun the largest higher education strike in U.S. history. The UC workers, represented by @UAW, are picketing at all 10 UC campuses this morning.
Yasar Arfat T Kasu retweeted
So proud of @Farhanlakdawal4 on his successful PhD defense today!
Thanks to committee members @CSwormlab, @JulietS38275263, @DrAveritt, and @CSBrower for their support and guidance.
Yasar Arfat T Kasu retweeted
Congrats to Bernadette Chua, who brilliantly defended her PhD thesis! Dr. Chua made incredible discoveries transforming how we think about proteostasis in stem cells. She was also central to building our kind, collaborative & supportive lab culture. My most joyous day as a PI!
