Dedicated physicians & scientists determined to improve outcomes in patients with gastrointestinal cancers through basic and translational research @DanaFarber

Boston, MA
Joined November 2020
Sethi_Lab retweeted
It is so exciting to build the understanding of the function differences between EP300 and CBP, which can be applied to target specific therapy development.
Replying to @ADurbinLab
This was a major effort between the @Adurbinlab @TheAbraLab @JunQiLab and the Ory labs. We pick up on a long-term interest of our labs: the attractive target, EP300. EP300 is a great cancer target because while many tumor cells require it, they often may not need its paralog CBP
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Interested in studying the origins of lung cancer and regulation of development, cell fate, metabolism in human lung progenitors? All in a rigorous, science-loving, supportive environment? I'm looking for postdoctoral fellows, students, technicians! DM me. Please retweet!
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Sethi_Lab retweeted
A New Era for Colorectal Cancer Care at MD Anderson - Scott Kopetz @skopetz oncodaily.com/industry/scott…
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Congratulations to @DanaFarber’s @nickpolizzi_ and @XinGu0317 who have received New Innovator Awards from the @NIH High-Risk, High-Reward Research program which supports early career investigators pursuing highly innovative research with potential for broad impact on biomedical and behavioral science. @DFCI_CancerBio Read more: bit.ly/4hKLs46
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Sethi_Lab retweeted
Exposure to high dietary fat increases ceramides and promotes cancer metastasis @ScienceMagazine @SwagataGoswam16 @EinsteinMed @ohyilmaz @Nilay_Sethi @DanaFarber science.org/doi/10.1126/scie…
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Very relevant finding for folks using CRISPRi in iPSC-derived neurons from @ophirshalem & team.
Happy to share the revised and now published in Cell Systems version of our paper, where we explore why dCas9-KRAB(KOX1) protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. Paper: doi.org/10.1016/j.cels.2026.…
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Sethi_Lab retweeted
Finishing your PhD or looking for a post-bac research position? We’re recruiting multiple postdocs and research technicians to study somatic evolution! Come do interdisciplinary science in a friendly, collaborative environment at @harvardmed Genetics. naxerova.hms.harvard.edu/con…
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Zenocutuzumab offers a new targeted treatment option for patients with previously treated, advanced NRG1 fusion-positive cholangiocarcinoma. @DanaFarber's James Cleary, MD, PhD, discusses in @OncLearnNetwork the approval and the role of comprehensive molecular testing. bit.ly/4h0u3Wy
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Advanced fellowship in leukemia @DanaFarber for 2027-2028, application is open. jobcenter.hematology.org/job…
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FDA approval in cholangiocarcinoma: The FDA has approved zenocutuzumab for NRG1+ Cholangiocarcinoma. @DanaFarber's @JamesClearyMD helped lead research of the drug in this rare cancer type which has had limited treatment options. ➡️bit.ly/4dlQ8vg
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My department at Oxford is recruiting junior faculty to the Ludwig Institute for Cancer Research. A collaborative and stimulating department, with great access to the breadth of the Oxford environment. The positions come with core funding and cutting edge technologies. If interested, apply here: shorturl.at/1ggGt
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We asked early career scientists what they need: funding access, grant writing support, and mentorship. @theNCI listened. We're launching a trans-institute training initiative to deliver exactly that. Learn more. cancer.gov/grants-training/n…
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#GI26 Our study underscores differing patient & physician perspectives on treatment trade-offs in 3L+ mCRC, particularly around #QOL and toxicity. Collaborative effort w/ @TakedaOncology #patientadvocate @cagirlinchi @colontown @Colorectalman @coloncanada @thermofisher
Colorectal cancer research at #ASCOGI26: Patients are more willing than physicians to trade some survival for better quality of life—like oral-only treatment or fewer side effects. Poster by @DanaFarber’s @ThejusJay. asco.org/abstracts-presentat…
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This is truly the perfect time to implement technology like this. We can accurately and swiftly annotate single cells based on their developmental potential with applications across biology and medicine. Excited to see this move ahead!
AI modeling of individual cell potential creates a vast space for new discoveries in cancer and #DevelopmentalBiology. brnw.ch/21wYfwC
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Sethi_Lab retweeted
It is so exciting to see the final version of our collaborative work with @LabSethi. We found that blocking HDAC1/2 pushes CRC cells out of a stem-like state and into differentiation. We will work tother more to find novel therapeutic options for CRC. authors.elsevier.com/c/1m7oK…
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!
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We’ve been busy 🐝s! Happy to share 5️⃣new preprints from the lab: one-liners below 👇#translocationRCC #CancerResearch @danafarber_GU [0/6]
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