Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn
University of Bonn
Joined December 2019
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We show that excess lipids in obesity suppress ACC1 in adipose ILC2s. Our findings also point towards an unexpected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance.
cell.com/cell-metabolism/ful…
cell.com/cell-metabolism/ful…
How does obesity disrupt ILC2 function and adipose tissue hoemostasis?
In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.
Wilhelm Lab retweeted
New! Online now: Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health dlvr.it/TVcSWf
Our findings also point towards an unexected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance. cell.com/cell-metabolism/ful…
Wilhelm Lab retweeted
We are excited to see our beloved study on Macrophage Arginine metabolism in Neuroinflammation published today in #NatureImmunology.
nature.com/articles/s41590-0….
It is time to celebrate 🍷🍻🥂
Wilhelm Lab retweeted
Honored to see our recent Nature study on neuro-epithelial circuits in anti-helminth immunity highlighted in this excellent News & Views. Many thanks to the authors @LabWilhelm for the thoughtful synthesis.
doi.org/10.1038/s41590-026-0…
Wilhelm Lab retweeted
A nice write-up from Nature Immunology about our recent paper!
nature.com/articles/s41590-0…
Our new paper out in @ImmunityCP Congratulations to first author Chantal Wientjens! cell.com/immunity/fulltext/S…
Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione
synthesis to prevent #ferroptosis and
support #lipid metabolism and expansion of type 2 immune cells in #asthma.
Wilhelm Lab retweeted
Online now: Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation dlvr.it/TPlGbt
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation | Nature Immunology nature.com/articles/s41590-0…
We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.
Wilhelm Lab retweeted
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten:
➡️dfg.de/de/service/presse/pre…
Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists. @UniBonn @ImmunoSens
Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten:
➡️dfg.de/de/service/presse/pre…
Wilhelm Lab retweeted
Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation @Fer_NK_nando
@TimMcCulloch nature.com/articles/s41467-0…
