@MoKhalilLab

Prof. @ Harvard University, Broad Institute, & Wyss Institute. Understanding the natural world by building a synthetic one. Website: https://xitter.cf/t.co/9daLuSS46q

Boston, MA
Joined May 2017
Attn eVOLVER users & enthusiasts. 2 BIG developments! 1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: khalil-lab.gitbook.io/evolve… 2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: evolver.bio/t/evolver-wiki-s…
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Mo Khalil retweeted
Fantastic Junior Group leader position at the Curie Institute in Paris!! Areas of interest include stem cells, tissue growth and morphogenesis, epigenetics, genomics, integrated physiology, metabolism, and synthetic embryo models. Please RT! jpi-recruitment-curie-umr321…
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Mo Khalil retweeted
Get after it @DARPA YFA is better than almost any other basic grant vehicle (yes looking at you R01s…) 🫡🇺🇸
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Mo Khalil retweeted
This work led by @jennbrophy7 and her student @vivzhong97 in collaboration with my lab & student Michaela Jones published online this morning at Nature Biotechnology nature.com/articles/s41587-0… Helps limit engr'd microbial functions to target plants Exciting science, amazing collab
We engineer both plants and bacteria to establish non-standard amino acids as a new molecular language for programming plant-microbe interactions. This work contributes to the growing toolkit for precision agriculture and we hope it accelerates the path to a sustainable future!
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Mo Khalil retweeted
We have two faculty positions open in synthetic biology (one experimental and one computational), both very broadly defined. Deadline is Oct 31. The Dept of Bioengineering in the Knight Campus at UOregon is a great place to work. Come join us! Link below.
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Mo Khalil retweeted
MCB Professor Ahmad (Mo) Khalil Receives Prestigious NIH Director’s Pioneer Award mcb.harvard.edu/department/n… @NIH @hseas @Harvard @MoKhalilLab
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1/5 Telomerase has long been linked to chromosome maintenance in eukaryotes. Now, we show that telomerase-like activity is also present in bacteria, shedding new light on its ancient origins. Excited to share that our work on DRT10 is now out in @Nature! nature.com/articles/s41586-0…
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Mo Khalil retweeted
Base editing and prime editing clinical trial landscape, including today’s GSD type I clinical readout from @BeamTx.
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PAM scanning, a CRISPR-based technique, maps where proteins tolerate insertions by testing function in living cells, and scales to any gene expressible in yeast. Out in JBC: 91 yeast GPCR chimeras, sites transferred to human A2A and MTNR1A receptors. doi.org/10.1016/j.jbc.2026.1…
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of course that's your contention. you're a first-year frontier bio guy. you just finished reading about CRISPR, probably watched a Doudna talk too. so now you're convinced everything is just gene editing. that's gonna last until next month when you discover base editing, and then you're gonna be talkin' about how cutting DNA was barbaric and double-strand breaks are a legacy approach. then you're gonna read about delivery, and suddenly everything's about lipid nanoparticles and how editing was the easy part and the whole goddamn thing is bottlenecked by getting it to the right organ. that'll last until somebody shows you AlphaFold, and then you're gonna be in here regurgitating DeepMind, talkin' about de novo enzymes and virtual cells and how wet labs are economically obsolete. then six months from now you'll watch one assay fail four times in a real lab, and start telling everybody the bottleneck was never ideas, it's validation. somewhere in there you'll find a guy named Keith on Telegram, and you'll start doing reconstitution math in your head at dinner. and by next year you're gonna be standing right here explaining to me you reversed your biological age by six years because you picked the clock that said so.
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Mo Khalil retweeted
Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :) 1. Mouse lineage from E0 to E13.5 science.org/doi/10.1126/scie… 2. A fluctuation test for gastruloid heterogeneity cell.com/cell/fulltext/S0092… Paper #1 covered in quoted thread. More on paper #2 here. 1/n
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
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Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in @CellCellPress! doi.org/10.1016/j.cell.2026.…
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Mo Khalil retweeted
Out today in @nature.com: our review on how single cells evolve into multicellular organisms, with Ozan Bozdag, @kai_tong_mc25, Peter Yunker, and Matt Herron. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.
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Harvard’s FAS is launching 25 tenure-track faculty searches, FAS Dean Hopi Hoekstra announced, loosening a hiring freeze instituted last spring as the school draws an influx of philanthropic support. @abbysgerstein and @amannmahajan report. thecrimson.com/article/2026/…
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I can't tell you how excited I am to expand our synthetic/systems biology research into the world of proteins, and in particular, to the superfamily of G-protein coupled receptors (GPCRs). I am so grateful to all our wonderful collaborators and mentors (you know who you are!)
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This vision grew out of the collective ideas, expertise, & creativity of a remarkable team of researchers who came together in our lab around a shared scientific challenge. I'm grateful for @NIH's support, which gives us the opportunity to work together to tackle this challenge.
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This announcement also gives me an opportunity to share that our lab has recently transitioned to @hseas @MCB_Harvard @broadinstitute. See: khalillab.github.io/
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Exciting news! Our team was selected to receive the @NIH Director's Pioneer Award! Our project asks: can we make a tool to perturb & map proteome function at scale, to do “do for proteins what CRISPR has done for genes"?
The NIH Director’s High-Risk, High-Reward Research Awards empower innovative scientists redefining the limits of biomedical and behavioral research. Meet the 2026 recipients of the NIH Director’s Pioneer, New Innovator, and Transformative Research Awards and discover the groundbreaking research they’re pursuing: go.nih.gov/BxJzhAG
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BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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We're searching for an assistant/associate professor in Bioengineering at Stanford! If you're using cutting-edge engineering approaches to understand or control biological systems in useful ways (medical, environmental, etc), we'd love to hear from you! facultypositions.stanford.ed…
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