@seb11pr

Professor, Pharmacology @UniGraz, Group leader @UniFreiburg, previously @CEpigenomics, epigenomics, technologies, aging, heart, kidney, macrophages

preissllab.org
Joined September 2021
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  • Following347
  • Followers268
❓What is the course of 🫀 remodeling and recovery during and after prolonged catecholamine treatment? 🐭 assigned to 14 days soprenaline+phenylephrine 🧬⬆️LV contractility/🫀fibrosis+hypertrophy 💊Targeted therapeutic approaches 🔓Read more: t.ly/F2E3L
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nature
@Nature13 Mar 2024
Nature research paper: Spatially organized cellular communities form the developing human heart go.nature.com/48Tw92N

Spatially organized cellular communities form the developing human heart

Nature - Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of...

nature.com
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Raphael Reuten@RaphaelReuten4 Mar 2024
Our #spatial #filtering #tool might be useful for a broader audience to dissect #mechanics #patterns in #AFM force maps nature.com/articles/s41596-0… @CIBSS_UniFR @UniFreiburg @NatRevMater
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Ob Genomanalyse von Tierarten oder des Coronavirus – der in Freiburg beheimatete europäische #GalaxyServer ist ein wichtiges Werkzeug für datenintensive Forschung. Bioinformatiker Björn Grüning erklärt, warum. badische-zeitung.de/wir-nenn… @bjoerngruening @galaxyproject #galaxyproject
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Beautiful cover image for February, courtesy of authors @UniFreiburg, shows whole mount image of the pacemaker cells, M2R, and glycocalyx of the cell membrane of a mouse sino-atrial-node. See their full article: buff.ly/3SND4pq @SlisaSG @Seb11pr @CallumZgierski @sfb1425
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Circulation Research@CircRes29 Jan 2024
Laurette et al found an efficient #AAV-based method for #CRISPRi-mediated epigenetic silencing of gene expression in cardiac myocytes in vivo and in vitro. Learn more at ahajrnls.org/3vQkYKl @Patrick_Irt @Ralf_Gilbach @Eileen_Furlong @LisaM_Weiss
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nature
@Nature13 Dec 2023
Nature research paper: Single-cell analysis of chromatin accessibility in the adult mouse brain go.nature.com/3tlArRC

Single-cell analysis of chromatin accessibility in the adult mouse brain

Nature - An atlas of candidate cis-regulatory DNA elements (cCREs) in the adult mouse brain unravels the transcriptional regulatory programs that drive the heterogeneity and complexity of brain...

nature.com
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nature
@Nature13 Dec 2023
This week in Nature: Brain maps - High-resolution cell atlas of entire mouse brain offers genomic, epigenetic and anatomical insights Browse the full issue: nature.com/nature/volumes/62…
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bioRxiv@biorxivpreprint25 Nov 2023
Age-related structural and functional changes of the intracardiac nervous system biorxiv.org/cgi/content/shor… #bioRxiv
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In 21 papers across Science, @ScienceAdvances, and @ScienceTM, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail. The results uncover the genetic organization of the human brain. scim.ag/4ro
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📅 Save the date! Don’t miss the 3rd Symposium on Medical Epigenetics by CRC992 MEDEP. 18-20 March 2024 in #Freiburg (Germany) Registration is already open: sfb992.uni-freiburg.de/sympo…
Even poster with event information and with line-up of speakers including keynote speakers Cigall Kadoch (Boston) and Adrian Bird (Edinburgh).

ALT Even poster with event information and with line-up of speakers including keynote speakers Cigall Kadoch (Boston) and Adrian Bird (Edinburgh).

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Yang Eric Li@YangEricLi12 Oct 2023
So excited that our work is published in Science today! 📣We profiled regulatory elements from 1.1 million cells across 42 distinct human brain regions🧠, and associated relevant cell types to 19 common neuropsychiatric disorders. @ScienceMagazine #BICCN doi.org/10.1126/science.adf7…

A comparative atlas of single-cell chromatin accessibility in the human brain

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function...

science.org
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realArnoldLab@realArnoldLab21 Sep 2023
Ancient question with a new twist! Check our new study by Schüle, Weckerle et al. authors.elsevier.com/c/1hekh… showing how TBX TFs Eomes&Brachyury specify cell lineages during gastrulation in a sequence. Eomes first dominates over Brachyury which only acts once Eomes left the scene.
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Cohesin
@Xieeee410 Aug 2023
🍺I am so excited that my first paper is online (nature.com/articles/s41594-0…)! Joint profiling of histone modifications and transcriptome are critical to understand the active or repressive gene regulatory network. We therefore develop Droplet Paired-Tag,
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Our August 2023 issue is now live! In this Focus issue (go.nature.com/3pYr3Sf) and its accompanying collection (go.nature.com/3Q59gn9), which includes older reviews, we highlight the exciting developments in single-cell omics and their transformative potential
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Do you enjoy the study of gene regulation and the outdoors? Come join our international team in sunny Freiburg, Germany! #phdposition #generegulation #spatial #singlecell #epigenetics #heart jobrxiv.org/job/preissl-lab-…

PhD in cardiovascular gene regulation (single cell, spatial genomics)

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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Cell Genomics@CellGenomics19 Jun 2023
Robust enhancer-gene regulation identified by single-cell transcriptomes and epigenomes dlvr.it/Sqvk60

Robust enhancer-gene regulation identified by single-cell transcriptomes and epigenomes

Integrated analysis of single-cell transcriptomes and epigenomes with a simple, permutation-based procedure detects cell-type-specific enhancer-gene associations. This procedure establishes stringent...

cell.com
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Open PhD position! If you are interested in analyzing the spatial dynamics of heart failure pathogenesis through integrative analysis of single cell transcriptomes, epigenomes and subcellular spatial transcriptomes, check here how to apply! meinbio.uni-freiburg.de/bild…
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Maike Sander & Lab@msanderlab25 May 2023
Out today @NatureGenet our work on mechanisms of beta cell dysfunctions in type 2 diabetes (T2D) combining single-cell genomics and Patch-seq. Congratulations to @GaoweiW @JoshChiou, Chun Zeng. Big thanks to @kjgaulton @seb11pr @bcellorg, F Kandeel, S Kim. rdcu.be/dcZQs
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Interpreting non-coding disease-associated human variants using single-cell epigenomics go.nature.com/3BsYVcp #Review by @kjgaulton, @seb11pr & Bing Ren @UCSDMedSchool @UniFreiburg @CEpigenomics @UCSanDiego @Ludwig_Cancer

Interpreting non-coding disease-associated human variants using single-cell epigenomics

Nature Reviews Genetics - In this Review, Gaulton et al. discuss how single-cell epigenomic methods generate cell type-, subtype- and state-resolved maps of candidate cis-regulatory elements in...

nature.com
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