Postdoc in the Translational Genomics of Diabetes Lab working on GWAS, function and polygenic risk. @StanfordMed formerly @ExeterMed @turinginst
Palo Alto, CA
Joined June 2017
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Seth Sharp retweeted
Out today from @StanfordPeds Endocrine Fellow #HectorOrtega & @SethASharp a state of the art review on polygenic risk scores (#PRS) in diabetes. This is your 101 on what we currently know about them and their application to understanding disease heterogeneity and clinical translation. @StanfordPeds @StanfordPedEndo @StanfordEndo @NIDDKgov
Read here for free - rdcu.be/eprel 1/4
Seth Sharp retweeted
Pleased to share our new preprint medrxiv.org/content/10.1101/…
- Genetically confirmed MODY have high T2D risk
~ 24% of phenotypic variance due to common genetic changes
- polygenic background alters diabetes risk 18 to 81%
Seth Sharp retweeted
5-drug precision prescribing for people with type 2 diabetes is here - @TheLancet our @ExeterMedmodel for optimising glucose lowering therapy using low-cost routine clinical features
Paper: thelancet.com/journals/lance…
Web calc: diabetesgenes.org/t2-treatme…
Thrilled to see GRS2 adopted in real world T1D screening and research studies. But clear we needed a standardized non-expert way to replicate our PRS. Great to work with @AmberMLuckett @Exeter_Diabetes @broadinstitute and @StanfordPeds colleagues to make a tool available!
Want to generate #T1DGRS in your data or data from any biobank? @SethASharp has updated his #GRS2 originally developed with @RAOram & @mnweedon - code available on @github Great collaboration with @AmberMLuckett medrxiv.org/content/10.1101/… github.com/sethsh7/prsedm @StanfordPeds @StanfordPedEndo 👇👇👇
Seth Sharp retweeted
🚨PREPRINT ALERT 🚨
Check out our latest manuscript on the role of the type 2 diabetes-associated gene RREB1.
@MouseteamGrace @annagloyn @rogercox02 @MelinaClaussnit @SvenssonLab @joshuawknowles @JoyYWu @susmandrup
Some highlights below 🧵
biorxiv.org/content/10.1101/…
Seth Sharp retweeted
Proteomic predictors of individualized nutrient-specific insulin secre... sciencedirect.com/science/ar… is the latest work from star fellow (and current faculty job hunter) Dr. Jelena Kolic @JelenaK86.
Seth Sharp retweeted
Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model. | Diabetes | American Diabetes Association diabetesjournals.org/diabete…
Seth Sharp retweeted
New in #PLOSBiology, @npburtt @kjgaulton &co present the type 1 #diabetes (#T1D) Knowledge Portal, an open-access resource that aims to help address the challenge of translating #genetic discoveries into mechanistic insight @AMP_CMDKP plos.io/3YrKuQt
ALT The T1DKP provides genetic and genomic data, pre-computed bioinformatics results, and expert-curated resources such as candidate gene lists to the T1D community.
Seth Sharp retweeted
Congratulations to all but especially to our very own #VarshaRajesh who won the staff technician award. We are so lucky you are in our team!!! @StanfordPedEndo
The Annual #Stanfordpeds Awards Day honored faculty & staff whose work & dedication help make the Department & @Stanford the great institution that it is today! Without their contributions, the advances of #stanfordpeds would not be possible! Congratulations!
Seth Sharp retweeted
Our T2D genetic clustering paper is free to read in #editorspicks of @DiabetologiaJnl March issue 🧬
Up front & free to read in our March issue #editorspicks : High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease bit.ly/3QlsQtj
Seth Sharp retweeted
NEW in @ScienceMagazine PUBLIC VIEWS ON POLYGENIC SCREENING OF EMBRYOS: We find substantial *superficial* interest in using emerging tech to increase the odds of having a child admitted to a top-100 college & conclude its time to consider regulation science.org/doi/10.1126/scie…🧵1/22
Seth Sharp retweeted
🚨An early Christmas Present👇
Congratulations to @antje_rottner on this tour de force - despite 700M pesky human cells, a transatlantic lab move & a global pandemic she delivered 580 genes which influence how much insulin human beta-cells contain. rdcu.be/c12EO
Seth Sharp retweeted
So excited to announce that my work with Colin Nichols during my fellowship @WUSTLPeds has finally been published! tandfonline.com/doi/figure/1…
Seth Sharp retweeted
Correction for participation bias in the UK Biobank reveals non-negligible impact on genetic associations and downstream analyses biorxiv.org/cgi/content/shor… #biorxiv_genetic
Seth Sharp retweeted
📢 New review on the pathway of precision medicine in type 1 diabetes from past ➡️ present @DiabetologiaJnl
Always a pleasure to work with @cevansmo @RAOram
link.springer.com/article/10…
Seth Sharp retweeted
🚨We are delighted to share our perspective on the importance of collaborative human islet research in elucidating the pathophysiology of all forms of #diabetes which is published today in @NatMetabolism. (1/7)
➡️ nature.com/articles/s42255-0…
One of the highlights of my PhD - getting to contribute to the discussion of polygenic prediction in mixed ancestry / ethnicity populations. The summary: for Type 1 diabetes general prediction holds up but risk distributions are different.
In Diabetes Care this month. The utility of T1D and T2D genetic scores in multiethnic children from the US SEARCH for Diabetes in Youth study.
diabetesjournals.org/care/ar…
@AmDiabetesAssn
@SethASharp
@DiabetesUK
@Exeter_Diabetes
@FerratLauric
@ExeterMed @JDRFResearch
#ADA2022
And a bonus finding of this study : clustering by genetic risk in 2 dimensions (Type 1 vs Type 2 diabetes) those with autoantibodies cluster the same (high T1D risk) regardless of measures of insulin resistance (e.g. waist hip ratio).