@ShlomchikLab

Autoimmunity, Lupus, Germinal Center B cells, Memory B cells, BCR signaling, Infectious Diseases

 Pittsburgh, PA
Joined August 2017
  • Tweets105
  • Following164
  • Followers1.1K
11Media
And check out the commentary by @RoserTP and @VinuesaLab: lnkd.in/ecVQm8N5

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Replying to @ShlomchikLab
@ShlomchikLab and his team have solved a 20-year #lupus mystery! In a new @jclinicalinvest paper, they show that TLR7 & TLR9 receptors signal differently, overturning textbook assumptions & explaining their opposite effects on #autoimmune disease. lnkd.in/extqYBYR
Eight microscopy images of B cell endosomes, which appear as colorful spheres, showing that chimeric TLR receptors made of TLR7 recognition elements with TLR9 signaling domains are localized in endosomes.

ALT Eight microscopy images of B cell endosomes, which appear as colorful spheres, showing that chimeric TLR receptors made of TLR7 recognition elements with TLR9 signaling domains are localized in endosomes.

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Mark Shlomchik Lab retweeted
Science Immunology@SciImmunology20 Feb 2023
Two analyses in mice examine how IL-21 and its receptor influence the creation of antibody-secreting B cells through germinal center interactions. @ShlomchikLab @luoweicool 📄: scim.ag/1Ch 📄: scim.ag/1Cf
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Mark Shlomchik Lab retweeted
Wei Luo@luoweicool28 Dec 2022
Read my latest #research published with @SpringerNature in @NatImmunol Key message: Immunization induced GC response and GC dependent memory formation require lipid homeostasis maintained by SCAP-SREBP signaling. nature.com/articles/s41590-0…
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Mark Shlomchik Lab retweeted
Nature Immunology@NatImmunol23 Sep 2022
Replying to @ClaireLeibler
@ClaireLeibler et al examine the TLR7/9 ‘paradox’, reporting that #TLR9 has two protective functions, including an as yet unidentified additional MyD88-independent signaling pathway that confers protection against #autoimmunity. @shlomchiklab @mshlomchik rdcu.be/cWdav
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Mark Shlomchik Lab retweeted
Dorina Avram@dorina_avram3 Oct 2020
Avram Lab at the Moffitt Cancer Center, department of immunology, is looking for a postdoc to study transcriptional and epigenetic control in immune responses an in tumors. Additional areas of research include novel regulators in colon cancer and colonic inflammation.
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While jobs in science, technology, engineering and mathematics (STEM) have grown nearly 80% since 1990, the diversity in these fields remains low. Read what a group of Pitt students are doing to change this: bit.ly/31SY43s
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Mark Shlomchik Lab retweeted
Pitt Micro/Immuno@Pitt_PMI12 Aug 2020
We are proud to announce the Microbiology and Immunology Diversity (MID) Scholars Program to engage URM students @PittTweet in research opportunities (with stipend!). Info and full application details here: pmi.pitt.edu/research Please retweet!
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Mark Shlomchik Lab retweeted
Dan Kaplan@KaplanLab4 Aug 2020
There is a postdoc spot in the Kaplan Lab for those interested in neuroimmunology. We have shovel ready projects. Also excited to create new projects based on your interest.
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Mark Shlomchik Lab retweeted
Delgoffe Lab@DelgoffeLab6 Dec 2019
Jeremy Tilstra (@ShlomchikLab) rocking out at the Senior Vice Chancellor’s @PittTweet seminar discussing his work (which we were honored to be included in) showing that T cells in lupus nephritis kidneys are functionally and metabolically exhausted! #immunometabolism
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Mark Shlomchik Lab retweeted
Waggoner Lab@LabWaggoner27 Nov 2019
IL-12 induced T-bet-high T cells suppresses Tfh differentiation, contributing to germinal center suppression during Salmonella infection cell.com/cell-reports/fullte…
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Mark Shlomchik Lab retweeted
ImmuneGCPapers@ImmuneGC_Papers28 Nov 2019
GC | IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression. dlvr.it/RKHhv0

IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal...

Germinal centers (GC) are crucial for the formation of long-lived humoral immunity. Many pathogens suppress GC, including Salmonella enterica serovar Typhimurium (STm), but the mechanisms driving...

pubmed.ncbi.nlm.nih.gov
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Mark Shlomchik Lab retweeted
Waggoner Lab@LabWaggoner12 Nov 2019
Infection by the intracellular bacterium Ehrlichia induces few—if any—GCs, yet it generates protective IgM memory B cells (MBCs). Liver & spleen are generative sites of E muris B cell responses, including V-region mutation and long-term MBC localization. cell.com/immunity/fulltext/S…

Liver Is a Generative Site for the B Cell Response to Ehrlichia muris

Infection by the intracellular bacterium Ehrlichia induces few—if any—germinal centers, yet it generates protective immunoglobulin M (IgM) memory B cells (MBCs). Trivedi et al. show that the liver...

cell.com
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Mark Shlomchik Lab retweeted
McHeyzer-Williams@mmw_lmw13 Nov 2019
#B_cell response to #Ehrlichia_muris | Liver and Spleen are Generative Sites | Mark Shlomchik @PittTweet @ImmunityCP buff.ly/2KijPR0
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Mark Shlomchik Lab retweeted
McHeyzer-Williams@mmw_lmw13 Nov 2019
#B_cell response to #Ehrlichia_muris | Liver and Spleen are Generative Sites | Mark Shlomchik @PittTweet @ImmunityCP buff.ly/2KijPR0
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Mark Shlomchik Lab retweeted
ImmuneGCPapers@ImmuneGC_Papers24 Apr 2019
GC | The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells. dlvr.it/R3Qnlg

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal...

B cell antigen receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to optimize selection for high-affinity B cells. In GCBC, BCR signals are constrained, but the...

pubmed.ncbi.nlm.nih.gov
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Congratulations to Dr. Olivera Finn! Her basic and applied research on tumor antigens and #cancer vaccines have played an integral role in the advancement of #immunotherapy. She will be a featured presenter during @sitcancer 34th annual meeting in November.
Society for Immunotherapy of Cancer
@sitcancer22 Mar 2019
SITC is pleased to announce Olivera J. Finn, PhD, of the University of Pittsburgh​ as the 2019 recipient of the Richard V. Smalley, MD, Memorial Award and Lectureship, the society's highest honor. News Release: sitcancer.org/aboutsitc/pres…
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Mark Shlomchik Lab retweeted
Pitt Micro/Immuno@Pitt_PMI26 Feb 2019
Congratulations to Dr. JoAnne Flynn on recieveing the @PittChancellor award for distinguished research on #tuberculosis !! at.pitt.edu/news/outstanding… #WomeninSTEM #pmiresearch
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Mark Shlomchik Lab retweeted
Hiroshi Yano, PhD
@HiroTheHero_PhD5 Oct 2018
Graduate student Nikita Trivedi from @ShlomchikLab presenting her work on Non-canonical B cell responses as a winner of last years poster presentation! University of Pittsburgh Immunology Retreat #PITTIMM2018
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Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted buff.ly/2zFx4X2 @PittHealthSci #autoimmune #nephrology
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