Yapeng Su (@SuYapeng) header
Yapeng Su (@SuYapeng) profile picture

Yapeng Su

@SuYapeng

K99-Damon Runyon Fellow @FredHutch, trainee of @labheath, David Baltimore, and Leroy Hood @Caltech & @isbsci. Systems Biology, Immunology, Cancer, Engineering

 Fred Hutch
Joined November 2019
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  • Followers553
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Photo by Yapeng Su (@SuYapeng)Photo by Yapeng Su (@SuYapeng)Photo by Yapeng Su (@SuYapeng)Photo by Yapeng Su (@SuYapeng)Photo by Yapeng Su (@SuYapeng)Photo by Yapeng Su (@SuYapeng)Photo by Yapeng Su (@SuYapeng)
Fred Hutch is bringing the 🔥 to #STATMadness! @SuYapeng and team uncovered how the sugar mannose supercharges T cells and boosts tumor control. Let’s run up the score — vote in @statnews’ bracket-style tournament now! 👉 bit.ly/4aUz4en
Image from Fred Hutch Cancer Center (@fredhutch)
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Two obstacles in #CancerImmunotherapy are tumor-infiltrating T cell exhaustion and mitochondrial dysfunction. Drs. @SuYapeng & Philip Greenberg at @FredHutch & @UW identified the E3 ubiquitin ligase KLHL6 as a dual-negative regulator of both. 🔎 Abstract: go.nature.com/4qqLAsK
Image from Science in Seattle (@science_seattle)
Image from Science in Seattle (@science_seattle)
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Zihai Li, MD, PhD (@Zihai) profile picture
Zihai Li, MD, PhD@ZihaiJan 14
This @Nature study (rdcu.be/eY5hC) shows that loss of the ubiquitin ligase KLHL6 in Tex cells prevents TOX degradation, stabilizing exhaustion and mitochondrial dysfunction. Another case linking proteostasis to T cell exhaustion. Congrats to @HutchGreenberg, Guideng Li.
Image from Zihai Li, MD, PhD (@Zihai)
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nature (@Nature) profile picture
nature
@NatureJan 16
Nature research paper: The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction go.nature.com/457rivW
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ISB (@isbsci) profile picture
ISB@isbsci10 Dec 2025
The spark that led to a Nobel. Dr. Mary Brunkow on the mentors who changed everything.
The Nobel Prize (@NobelPrize) profile pictureThe Nobel Prize
@NobelPrize7 Dec 2025
“I wouldn't be standing here today if it weren't for a couple of really important mentors in my life who showed me what a life in research would look like.” During her Nobel Prize lecture, medicine laureate Mary Brunkow spoke about the people that helped her during her scientific journey. Watch her full lecture: youtube.com/watch?v=n1tfKu3e…
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ISB (@isbsci) profile picture
ISB@isbsci5 Dec 2025
🚨 Breaking: ISB wins a 2025 #AWSImagineGrant! The funding will supercharge Tarpon, our generative-AI platform that decodes T-cell receptors into digital immune fingerprints — a game-changer for immune-based therapies. Read more ➤ isbscience.org/news/press-re… @awscloud
ISB Named Winner of 2025 Amazon Web Services Imagine Grant for Nonprofits

ISB Named Winner of 2025 Amazon Web Services Imagine Grant for Nonprofits  

ISB wins AWS Imagine Grant to launch Tarpon, a generative AI platform that decodes and designs human immune responses for next-gen therapies.

isbscience.org
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Yapeng Su retweeted
Cell (@CellCellPress) profile picture
Cell@CellCellPress18 Nov 2025
In the latest issue! Remembering David Baltimore (1938–2025) dlvr.it/TPKHDs
Remembering David Baltimore (1938–2025)

Remembering David Baltimore (1938–2025)

David Baltimore, one of modern biology’s most influential scientists, passed away at his home in Woods Hole, Massachusetts, on September 6, 2025 at the age of 87, leaving legions of former trainees...

cell.com
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Say good morning to our new medicine laureate Mary Brunkow! 🎉 This photo was taken by Brunkow's husband Ross Colquhoun at 4:30 in the morning, just after she had received the news.
Image from The Nobel Prize (@NobelPrize)
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We are looking for talented postdocs/visiting students to join our team @MITdeptofBE and @kochinstitute to innovate spatial multi-omics technologies, map clinical samples, and integrate AI/ML models to advance next-generation cancer immunotherapy. Please help to spread!!
Image from Zhiliang (@Zhiliang_Bai)
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Reduced mannose metabolism is a feature of exhausted T cells that can be targeted to enhance memory , persistence, and antitumor function of adoptively transferred T cells cell.com/cancer-cell/fulltex… Preview @Cancer_Cell @paulbeavis4 @ChScheffler cell.com/cancer-cell/fulltex…
Image from Waggoner Lab (@LabWaggoner)
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#NatMetabPicks | In @Cancer_Cell, from Philip D. Greenberg, @Guideng4 (@fredhutch, @uwsomwwami; CAMS and PUMC, CN) and co-authors, describing how #mannose metabolism reshapes #Tcell differentiation to enhance #antitumor #immunity 🐭 cell.com/cancer-cell/fulltex…
Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

Qiu et al. identify that reduced mannose metabolism is a key characteristic of T cell dysfunction. Enhancing mannose metabolism in T cells through D-mannose supplementation boosts anti-tumor activi...

cell.com
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The recipient of the 2024 Damon Runyon-Jake Wetchler Award for Pediatric Innovation is @SuYapeng , a Quantitative Biology Fellow working on next-generation immunotherapies that can be more easily scaled to help more patients.
Image from Damon Runyon Cancer Research Foundation (@DamonRunyon)
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@gulleyj1 (@gulleyj1) profile picture
@gulleyj1@gulleyj19 Nov 2023
What an incredible #Sparkathon class! Such a pleasure to meet up with them at #SITC23!
Alex Tikhonov (@AlexTihonoff) profile pictureAlex Tikhonov@AlexTihonoff5 Nov 2023
Replying to @gulleyj1 @JennGuerriero
Best picture!
Image from Alex Tikhonov (@AlexTihonoff)
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@gulleyj1 (@gulleyj1) profile picture
@gulleyj1@gulleyj15 Nov 2023
Love this class of #Sparkies! #SITC23 ⁦@JennGuerriero⁩
Image from @gulleyj1 (@gulleyj1)
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Caltech (@Caltech) profile picture
Caltech@Caltech4 Oct 2022
Congratulations to Caltech alumnus John F. Clauser (BS ‘64) who shares the 2022 #NobelPrize in Physics “for experiments with entangled photons, establishing the violation of Bell inequalities pioneering quantum information science.”
Image from Caltech (@Caltech)
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Institute for Systems Biology awarded $13M to study administering cancer drugs in succession geekwire.com/2022/institute-… via @GeekWire
Institute for Systems Biology awarded $13M to study administering cancer drugs in succession

Institute for Systems Biology awarded $13M to study administering cancer drugs in succession

The National Cancer Institute has awarded Seattle’s Institute for Systems Biology $13 million to lead a collaborative cancer center studying two key types

geekwire.com
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This is so interesting, giving the report by @SuYapeng et al showing similar reduction in long haulers with respiratory viral symptoms at 2-3 months post COVID. This implies chronic hypocortisolism in long COVID. (14/)
Image from Prof. Akiko Iwasaki (@VirusesImmunity)
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Here is the summary of our findings. There are many implications for diagnosis and therapy for #longCOVID. (26/)
Image from Prof. Akiko Iwasaki (@VirusesImmunity)
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ISB (@isbsci) profile picture
ISB@isbsci23 May 2022
Informative #LongCovid story by @nytimes' @PamBelluck & @KnvulS. The article includes details from the recent @CellCellPress paper by Drs. @SuYapeng @LabHeath et al. on the four predictive factors of PASC.
The New York Times (@nytimes) profile pictureThe New York Times
@nytimes23 May 2022
There is no universal definition of long Covid, but clues about causes and potential treatments are beginning to emerge. Here's what we know so far. nyti.ms/3GhRHJF
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ISB (@isbsci) profile picture
ISB@isbsci19 May 2022
Study looks for #LongCovid risk factors. @NIH @NIAIDNews @LabHeath @SuYapeng @Swedish @providence covid19.nih.gov/news-and-sto…
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