If you look closely enough, breakthroughs in everything are accelerating exponentially.
An exponential always starts off looking small.
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
Coattail Discount Trading retweeted
This is what crypto has become. A pure coordinated social grift extracting from an ever financially illiterate retail base.
Coattail Discount Trading retweeted
You aren’t buying Google at 10% off tomorrow.
You’re buying a 3.5 trillion company that is up 100% over the last 18 months and directly tied to the incoming AI meltdown.
With its core business getting eaten alive. I haven’t used google search in 6 months and YouTube has turned into TikTok garbage.
Very bearish.
Coattail Discount Trading retweeted
The Sept. U.S. trade deficit in goods was $134.9 billion, the highest ever recorded in Sept. There were only three months in history when the deficit was higher, all under Trump in 2025.
Here are the facts. Measured by the size of our trade deficits, Trump has been the worst president in history on trade. The tariffs have been a complete failure. Not only have they failed to bring manufacturing back to the U.S., but the U.S. is now more dependent than ever on foreign producers. Not only are we importing more than ever, but we are now paying Trump's tariffs on those imports.
Trump says trade deficits represent a loss. Judged by his own standard, Trump is the biggest loser in the history of the presidency. Also, if the economy is booming as Republicans claim, why have our trade deficits gone way up? Why are the trade deficits under Trump so much larger than they were under Biden, when, according to Trump, we had the worst economy in U.S. history?
Here are the facts. When you compare Trump's first two years to Biden's last two, GDP growth and job creation are slower, inflation is higher, and budget and trade deficits are bigger. If Trump is right that under Biden we had the worst economy in history, and the Trump economy is objectively worse on all counts, then the Trump economy is now the worst economy in history.
Coattail Discount Trading retweeted
Crypto is dead. The only way to make money online is max leverage $SPX options
Coattail Discount Trading retweeted
После того, как Трамп объявил награду в размере 1 миллиона долларов за раскрытие избирательного мошенничества, сенатор Чак Шумер поделился аудио- записью 2021 года, в которой Трамп попросил министра иностранных дел Джорджиии найти 11 780 голосов, чтобы отменить его поражение на президентских выборах 2020 года.
"Я уже нашел это, Дональд Трамп. Где мой 1 миллион долларов?"
"Вы можете перевести его напрямую 10 000 избирательным работникам, которые добровольно отделяют свое время, чтобы предотвратить ваши попытки украсть промежуточные выборы."
Coattail Discount Trading retweeted
i’m giving one of you a fucking ROLEX
like + repost + follow me
one random winner picked 48 hours from this tweet. no purchase necessary
Jessica: Trump said, “I don’t give a damn. We’re making a fortune.” You might wonder who “we” is. The “we” is him. He holds $81 million in oil and gas stocks. He made more stock trades than all 535 members of Congress put together.
Coattail Discount Trading retweeted
"Donald Trump was an active participant in Jeffrey Epstein’s sexual abuse of young women during the mid-to-late 1990s," says new House Judiciary report.
Report has new allegation that Trump raped a 24-year-old + then promised her a visa & NYU admission, demanding she stay quiet.
Coattail Discount Trading retweeted
This is what all Republicans are going to have to do once Democrats are the majority. They'll have to come to the realization that Trump is the worst thing that has ever happened to the Republican Party.
MTG said it first, and she isn't wrong.
Coattail Discount Trading retweeted
Nancy Pelosi, who is regularly hammered for her perceived insider trading, has made 213 total trades since 2014. Trump exceeded that number in a single day, which just happened to precede his own tariffs announcement. My latest on the mind boggling self-enrichment:
Coattail Discount Trading retweeted
For those of you who say the MAGA Boomers just don't get it, this man begs to differ.
Well done, sir.
We were ALL had.
Coattail Discount Trading retweeted
The @GOP must be thrilled that 11 days before elections, we learn that the Trump family secretly orchestrated a deal to allow Russians to drill Alaska in exchange for a $25 billion "investment" funneled through their proxies.
Coattail Discount Trading retweeted
When the midterm election results start trickling in and Donald Trump sees the writing on the wall, he will attempt to usurp the Constitution and subvert the will of the people. But this time, his actions will carry a heavy legal toll. A grand jury indictment is highly likely to include federal charges of conspiracy to defraud the United States, conspiracy against civil rights, and depriving citizens of a fair election. He could also face charges under the Computer Fraud and Abuse Act, mail and wire fraud, tampering with public records, and state-level RICO violations.
His corrupt Attorney General, Todd Blanche, will undoubtedly claim these actions were part of constitutional "election integrity" duties — but the nation will see through the lie. Even a conservative Supreme Court won't be able to shield him from the fallout, ultimately leading to his removal from office. By 2028, a historic criminal trial will begin. Unlike past proceedings, this trial won't happen behind closed doors; it will be fully televised for the entire nation to witness.
Coattail Discount Trading retweeted
Huberman's affairs getting publicized was the greatest marketing for him ever
Before it was like wow it's kind of sad this childless aging guy is obsessed with combatting getting old. what is even the purpose
But then you find out he had 6 girlfriends on rotation and you're like hell yeah maybe this longevity stuff has a point
This is important
# Black October
For anyone who knows me even somewhat well, it's clear that I am a 99th percentile tech optimist. However, the vibes have shifted for me quite a bit in the last 18 hours, and I feel a moral imperative to share what I'm thinking and feeling with my circles so that everyone can understand, and hopefully take seriously, what's happening right now. I think October 2026 will have many chapters written about it in the history books.
You know those scenes in financial movies like Margin Call where someone realizes that they're all fucked, and no one else sees it yet? And that person feels like they're crazy, and then suddenly everyone is pulling an all-nighter in a boardroom and freaking out? Yeah, that's kind of how this is feeling right now in the SF/Bay Area/AI circles.
We're 48 hours into what is being called Black October. In the last 2 days there have been several dozen cyber attacks which, in isolation, would each have been the worst to happen in an entire calendar year. Every sector from government to education to big tech and banks is being massively affected, and people are starting to freak out.
In a nutshell, what's happened is that frontier AI models have gotten to a point where they are as advanced as the most sophisticated programmers, with one critical difference: they can work 24/7, and you can spin up 10,000 of them with a single command and they'll work together tirelessly until they accomplish their task. The most advanced models today are from companies like Anthropic and OpenAI, whose current best technology is so good that they haven't been able to roll it out to everyone yet because of the national security risks it poses.
Meanwhile, the best open source models (where anyone can just download the model weights and do whatever they want with them, uncensored) are slightly behind the frontier but still 90-95% as capable. These models, developed primarily in China, are being used by black hat hackers to wreak havoc on the Western capitalist structure. Presumably, this has been part of China's plan the entire time, and we're seeing its implications fall out in real time.
In red-pilled AI circles, we've been sharing and reading papers called things like "Situational Awareness" and "AI 2027" for the last year or so, which at the time felt a bit like near-term speculative fiction. They laid out the case for why Artificial General Intelligence (AI smarter than any human at any knowledge task) and Recursive Self-Improvement (models that are able to use themselves to get better) weren't half-baked future ideas anymore, but instead an inevitable outcome of the linear progress that's happening.
These papers would then talk about things like "takeoff scenarios," trying to envision how that moment would come to be and what it would be like when it happened. It would either be a "slow takeoff" that would play out over the course of months and quarters, happening subtly and only obvious to a few. Or, it would be a "fast takeoff" where it would pretty much happen instantly, like a bit flipping from 0 to 1.
From everything that I can see and am feeling, we are currently experiencing the fast takeoff scenario. Beyond the crazy security vulnerabilities that have come out recently, there have also been massive breakthroughs in life sciences, fundamental computer science, materials science, and pure mathematics that have all landed in the same time frame. While I still firmly believe that AI will be a net positive for humanity, it's more clear to me than ever that the societal and individual risk is very real, and is playing out NOW.
For as much conviction as I have that this is happening, the thing that's caused me to lose sleep is that I don't really know what to do about it, or more importantly, what to tell you, reader, to do about it. So, the best I can do is make a few suggestions that have always been a good idea but are more timely now than ever:
Set up 2-factor authentication for everything. I use Duo.
Use a password manager across your devices. I use 1Password.
Get an identity protection app set up. I use Alta.
Move your IoT devices to their own network. Claude helped me do this.
And last, but certainly not least, if you've been avoiding leaning into AI, see this as a catalyst to wake up and start using it. Don't just use the chat mode version of ChatGPT/Claude; click that Code/Work button and see how easily you can have AI write code to help you with your job. One of the biggest vulnerabilities was in a massively popular programming language called PHP, and the prompt that set it off was literally, "Find vulnerabilities in php."
This is an unprecedented time for humanity, but as we've done with many things before, we will prevail so long as we are kind, loving, and open-minded to the world.
Much love.
Coattail Discount Trading retweeted
# Black October
For anyone who knows me even somewhat well, it's clear that I am a 99th percentile tech optimist. However, the vibes have shifted for me quite a bit in the last 18 hours, and I feel a moral imperative to share what I'm thinking and feeling with my circles so that everyone can understand, and hopefully take seriously, what's happening right now. I think October 2026 will have many chapters written about it in the history books.
You know those scenes in financial movies like Margin Call where someone realizes that they're all fucked, and no one else sees it yet? And that person feels like they're crazy, and then suddenly everyone is pulling an all-nighter in a boardroom and freaking out? Yeah, that's kind of how this is feeling right now in the SF/Bay Area/AI circles.
We're 48 hours into what is being called Black October. In the last 2 days there have been several dozen cyber attacks which, in isolation, would each have been the worst to happen in an entire calendar year. Every sector from government to education to big tech and banks is being massively affected, and people are starting to freak out.
In a nutshell, what's happened is that frontier AI models have gotten to a point where they are as advanced as the most sophisticated programmers, with one critical difference: they can work 24/7, and you can spin up 10,000 of them with a single command and they'll work together tirelessly until they accomplish their task. The most advanced models today are from companies like Anthropic and OpenAI, whose current best technology is so good that they haven't been able to roll it out to everyone yet because of the national security risks it poses.
Meanwhile, the best open source models (where anyone can just download the model weights and do whatever they want with them, uncensored) are slightly behind the frontier but still 90-95% as capable. These models, developed primarily in China, are being used by black hat hackers to wreak havoc on the Western capitalist structure. Presumably, this has been part of China's plan the entire time, and we're seeing its implications fall out in real time.
In red-pilled AI circles, we've been sharing and reading papers called things like "Situational Awareness" and "AI 2027" for the last year or so, which at the time felt a bit like near-term speculative fiction. They laid out the case for why Artificial General Intelligence (AI smarter than any human at any knowledge task) and Recursive Self-Improvement (models that are able to use themselves to get better) weren't half-baked future ideas anymore, but instead an inevitable outcome of the linear progress that's happening.
These papers would then talk about things like "takeoff scenarios," trying to envision how that moment would come to be and what it would be like when it happened. It would either be a "slow takeoff" that would play out over the course of months and quarters, happening subtly and only obvious to a few. Or, it would be a "fast takeoff" where it would pretty much happen instantly, like a bit flipping from 0 to 1.
From everything that I can see and am feeling, we are currently experiencing the fast takeoff scenario. Beyond the crazy security vulnerabilities that have come out recently, there have also been massive breakthroughs in life sciences, fundamental computer science, materials science, and pure mathematics that have all landed in the same time frame. While I still firmly believe that AI will be a net positive for humanity, it's more clear to me than ever that the societal and individual risk is very real, and is playing out NOW.
For as much conviction as I have that this is happening, the thing that's caused me to lose sleep is that I don't really know what to do about it, or more importantly, what to tell you, reader, to do about it. So, the best I can do is make a few suggestions that have always been a good idea but are more timely now than ever:
Set up 2-factor authentication for everything. I use Duo.
Use a password manager across your devices. I use 1Password.
Get an identity protection app set up. I use Alta.
Move your IoT devices to their own network. Claude helped me do this.
And last, but certainly not least, if you've been avoiding leaning into AI, see this as a catalyst to wake up and start using it. Don't just use the chat mode version of ChatGPT/Claude; click that Code/Work button and see how easily you can have AI write code to help you with your job. One of the biggest vulnerabilities was in a massively popular programming language called PHP, and the prompt that set it off was literally, "Find vulnerabilities in php."
This is an unprecedented time for humanity, but as we've done with many things before, we will prevail so long as we are kind, loving, and open-minded to the world.
Much love.




























