Carlos L. Araya (@claraya) header
Carlos L. Araya (@claraya) profile picture

🌳| Explore, Anywhere; 🧬| Modeling, Invitae; 👨‍🚀| CEO, Jungla; 🔬| Genetics, Stanford; 🎓| Genome Sciences, UW; 🌋,🏔,🌊,🏕️| Costa Rica, Norge, Brasil, USA

Joined March 2008
Photo by Carlos L. Araya (@claraya)Photo by Carlos L. Araya (@claraya)Photo by Carlos L. Araya (@claraya)Photo by Carlos L. Araya (@claraya)Photo by Carlos L. Araya (@claraya)Photo by Carlos L. Araya (@claraya)
Carlos L. Araya retweeted
Doing good science is 90% finding a science buddy to constantly talk to about the project.
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Carlos L. Araya retweeted
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
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Carlos L. Araya retweeted
Sam Altman is a hero of mine. He built a company from nothing to $90 Billion in value, and changed our collective world forever. I can't wait to see what he does next. I, and billions of people, will benefit from his future work- it's going to be simply incredible. Thank you @sama for all you have done for all of us.
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Carlos L. Araya retweeted
The gov’t has about 48 hours to fix a-soon-to-be-irreversible mistake. By allowing @SVB_Financial to fail without protecting all depositors, the world has woken up to what an uninsured deposit is — an unsecured illiquid claim on a failed bank. Absent @jpmorgan @citi or @BankofAmerica acquiring SVB before the open on Monday, a prospect I believe to be unlikely, or the gov’t guaranteeing all of SVB’s deposits, the giant sucking sound you will hear will be the withdrawal of substantially all uninsured deposits from all but the ‘systemically important banks’ (SIBs). These funds will be transferred to the SIBs, US Treasury (UST) money market funds and short-term UST. There is already pressure to transfer cash to short-term UST and UST money market accounts due to the substantially higher yields available on risk-free UST vs. bank deposits. These withdrawals will drain liquidity from community, regional and other banks and begin the destruction of these important institutions. The increased demand for short-term UST will drive short rates lower complicating the @federalreserve’s efforts to raise rates to slow the economy. Already thousands of the fastest growing, most innovative venture-backed companies in the U.S. will begin to fail to make payroll next week. Had the gov’t stepped in on Friday to guarantee SVB’s deposits (in exchange for penny warrants which would have wiped out the substantial majority of its equity value) this could have been avoided and SVB’s 40-year franchise value could have been preserved and transferred to a new owner in exchange for an equity injection. We would have been open to participating. This approach would have minimized the risk of any gov’t losses, and created the potential for substantial profits from the rescue. Instead, I think it is now unlikely any buyer will emerge to acquire the failed bank. The gov’t’s approach has guaranteed that more risk will be concentrated in the SIBs at the expense of other banks, which itself creates more systemic risk. For those who make the case that depositors be damned as it would create moral hazard to save them, consider the feasibility of a world where each depositor must do their own credit assessment of the bank they choose to bank with. I am a pretty sophisticated financial analyst and I find most banks to be a black box despite the 1,000s of pages of @SECGov filings available on each bank. SVB’s senior management made a basic mistake. They invested short-term deposits in longer-term, fixed-rate assets. Thereafter short-term rates went up and a bank run ensued. Senior management screwed up and they should lose their jobs. The @FDICgov and OCC also screwed up. It is their job to monitor our banking system for risk and SVB should have been high on their watch list with more than $200B of assets and $170B of deposits from business borrowers in effectively the same industry. The FDIC’s and OCC’s failure to do their jobs should not be allowed to cause the destruction of 1,000s of our nation’s highest potential and highest growth businesses (and the resulting losses of 10s of 1,000s of jobs for some of our most talented younger generation) while also permanently impairing our community and regional banks’ access to low-cost deposits. This administration is particularly opposed to concentrations of power. Ironically, its approach to SVB’s failure guarantees duopolistic banking risk concentration in a handful of SIBs. My back-of-the envelope review of SVB’s balance sheet suggests that even in a liquidation, depositors should eventually get back about 98% of their deposits, but eventually is too long when you have payroll to meet next week. So even without assigning any franchise value to SVB, the cost of a gov’t guarantee of SVB deposits would be minimal. On the other hand, the unintended consequences of the gov’t’s failure to guarantee SVB deposits are vast and profound and need to be considered and addressed before Monday. Otherwise, watch out below.
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Carlos L. Araya retweeted
Creelo Fideo, somos campeones 🙏🏆 #rosario3 #qatar2022 #mundial2022 #argentina #somoscampeones
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'It will go down as an all-time classic, perhaps the finest World Cup final of them all. It was destined to be Lionel Messi's game in the end, and yet how France and Kylian Mbappé fought.' World Cup final match report by @DaveHytner theguardian.com/football/202…
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Carlos L. Araya retweeted
Just published @ScienceMagazine A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, effective in experimental models science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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Carlos L. Araya retweeted
Sorry, who did this? 😂
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learning to code in R
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I’m back to work, parked between these two beautiful outcrops. Been doing some imaging, weather studies, chemistry experiments and getting a software update too. Latest pics: go.nasa.gov/perseverance-raw…
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We’ve lost a wonderful scientist with the passing of Dan Tawfik. His creative pursuits brought us to better understand protein stability, robustness, dynamics, and evolvability. His work was an inspiration for many assays that serve modern medicine. nature.com/articles/s41589-0…
Carlos L. Araya retweeted
We generally see more rapid logistic growth of P.1 across individual states as well. These 9 were chosen as those with the most data. All these plots only go to Apr 14, as there is a necessary lag to the genomic data as samples are processed. 4/13
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Carlos L. Araya retweeted
We are fortunate that vaccines induce such a strong immune response and provide protection from all of the virus variants that have evolved to date
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Carlos L. Araya retweeted
We now have solid evidence that there are vaccines that protect against all variants of concern: ✓ B.1.351 (S Africa) ✓ P.1 (Brazil) ✓ B.1.1.7 (UK) ✓ B.1.526 (NY) ✓ B.1.429 (CA)
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Carlos L. Araya retweeted
When the largest state of 40 million people has achieved containment down to 4 cases/100,000 people, for the first time since March 2020, and 1% test positivity, that's a very good sign
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Carlos L. Araya retweeted
There are effectively two #COVID19 epidemics in the US at this moment; one largely resolving epidemic comprised of non-variant viruses and one growing epidemic of B.1.1.7. Together they have resulted in a near-plateau of cases throughout much of the spring. 1/10
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Sometimes people are like "it must have been crazy when the Glow pt. 2 got popular" and I say "not really". For example, here's a poster from then for a show that cost $1.50, a cool price.
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