Group Leader in Induced Proximity & Targeted Protein Degradation, Chemical Biology @SAiGENCI 🦘 | Structural Biology & Drug Discovery | (Pseudo)kinases
Joined October 2018
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Beautiful work by the team! Very exiting to see this out.
Thrilled to share that, together with my colleagues @UoDCeTPD and collaborators @Boehringer, we report @ScienceMagazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/scie…
Michael Roy retweeted
So nice to see this paper out in its final form. Hope our learnings can help you identify and confirm true, on-target degraders!
Big thanks to the project team across both organisations @UoDCeTPD @Boehringer @alessiociulli
pubs.acs.org/doi/10.1021/acs…
Michael Roy retweeted
Thrilled about our latest Pseudokinase research published today in @CommsBio, showing EphB6 power in promoting cell cell adhesion through formation of intercellular tubes. Many congratulations to our star PhD student @LungYu_Liang.
Awesome to see this fantastic study of the elusive EphB6 pseudokinase in print at long last nature.com/articles/s42003-0…
Massive congrats to star PhD student @LungYu_Liang (now in Frankfurt) who bravely took on this toughest of projects with @Isa_Lucet and me
Michael Roy retweeted
Proud to sign this open letter from the Australian health sector and join with @VACCHO_org and Victorian health leaders in support of a Yes vote in the upcoming referendum 🧵
#VoteYes
ALT This document is titled "An Open Letter to the Australian Public: A Voice to Parliament will improve health outcomes". In includes explanatory text about why the organisations listed are supporting a Yes vote in the upcoming referendum.
Michael Roy retweeted
The Australian Centre for Targeted Therapeutics (ACTT) at @WEHI_research is hiring a Senior Research Scientist (Lead Scientist, Protein Biochemistry) to help develop novel targeted protein degrader drugs. Info and applications here: wehi.wd3.myworkdayjobs.com/W…
Michael Roy retweeted
Excited to be part of a new collaboration to address current gaps in Australia’s #DrugDiscovery pipeline, which has been awarded $9.75m from the #MRFF.
🧵1/4
ALT Excited to be part of a new collaboration to address current gaps in Australia’s #DrugDiscovery pipeline, which has been awarded $9.75m from the #MRFF.
Michael Roy retweeted
💊to the Chemists looking for a Postdoc:
📢we have an open position in the targeted protein degradation & antibiotic research lab @theCrick!
🔗crick.ac.uk/careers-study/va…
So many exciting postdoc opportunities!
PLease RT! We have 4x opening at postdoctoral level to join our new @CeTPD_Dundee. Covering all range of disciplines, both academic in @farnaby84 team and in our drug-discovery teams @Boehringer and @AlmirallUS. DM for informal enquiries dundee.ac.uk/cetpd/vacancies
Michael Roy retweeted
Taking a BiTE out of KRAS G12C drug resistant tumors with cell surface drug presentation. 🙏 @CraikLab for collaborating on our first adventure in biologics. @bignerdzzy @PRoh_94 @UCSFCancer @HHMINEWS cell.com/cancer-cell/fulltex…
Michael Roy retweeted
Looking for an enthusiastic medicinal chemist to join @Sleebs_Lab @WEHI_research on an exciting oncology program in collaboration with an industry partner.
For further details,
seek.com.au/job/58192361?tra…
Michael Roy retweeted
I'm really pleased to share a tool I developed with colleagues at Edinburgh University - designed to support academics in managing their research careers. 1/11
Will be great to bring together the Australian TPD community for #DegradersDownUnder, a hybrid conference on 12-13 July 2022, in person @WEHI_research and online. Free registration: eventbrite.com.au/e/degrader…
The first Australian #TPD meeting will be held in July! In person @WEHI_research and online. Registration open now #DegradersDownUnder
Michael Roy retweeted
The first Australian #TPD meeting will be held in July! In person @WEHI_research and online. Registration open now #DegradersDownUnder
Michael Roy retweeted
I am pleased to introduce DEGRONOPEDIA - a web server for degron screening. It provides complex degron information (i.a. nearby residues that may be ubiquitinated, PTMs, disorder) and allows for Machine Learning predictions of N-/C-termini stability. 1/11
biorxiv.org/content/10.1101/…
What a beautiful structure!
Our latest manuscript, “Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome,” is now published at BioRxiv. biorxiv.org/content/10.1101/…
Please RT - We're after three researchers to join our expanding team to discover new targeted protein degraders to fight cancer, in the @WEHI_research - @Boehringer collaboration: 2x chemists (bit.ly/TPD-MedChem), 1x cell biologist (bit.ly/TPD-CellBiol). Closing 21 Feb.
Michael Roy retweeted
Optimization of Phosphotyrosine Peptides that Target the SH2 Domain of SOCS1 and Block Substrate Ubiquitination pubs.acs.org/doi/10.1021/acs…
Beautiful study - well done all!
Delighted to share our paper on PINK1, now out in @Nature. We structurally characterised the entire activation mechanism of PINK1 using crystallography and cryo-EM. Thank you to everyone who contributed! @komander_lab @WEHI_research rdcu.be/cDDHl nature.com/articles/s41586-0…