@evotobi

Evolutionary Immunogenomics, #HLA/#MHC, PopGen, #EvMed, and everything in between. Professor @UniHH

 Hamburg, Germany
biologie.uni-hamburg.de/evolutionaryimmunogenomics
Joined January 2016
  • Tweets1.3K
  • Following197
  • Followers787
I am permanently moving over and abandoning this profile, for all the known reasons. See you on the other side, where the sky is still blue! 🦋 @biotobi.bsky.social bsky.app/profile/biotobi.bsk…
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How To Choose a Good Scientific Problem @CellCellPress sciencedirect.com/science/ar…
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The distribution of ~ 2 trillion immune cells in the human body.
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Tobias L Lenz retweeted
Stephen Turner@strnr14 Sep 2024
We're cooked.
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We are advertizing a #PhD position in our lab to study evolutionary genetics of adaptive immunity in humans and/or fish. We use computational and molecular approaches. Topic open, to be matched with student's interest/skills. Come join us! #MHC #HLA #TCR uni-hamburg.de/en/stellenang…
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Excited to be part of this huge effort with @evotobi and @MeyerBritta. Here we led annotation of MHC I/II diploid haplotypes of six ape species. This is a huge advance for primate immunogenomics! I am currently adopting some of this for marmosets. biorxiv.org/content/10.1101/…

Complete sequencing of ape genomes

We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve...

biorxiv.org
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Big congrats to Synne Arstad Bjørnestad defending her PhD thesis yesterday 🙌🙌 think we have come a little closer in understanding the immune function in Atlantic cod 🐟 and thanks to the two opponents for the nice discussions @evotobi and Ilana Berlin 🤗🤗
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See our new comprehensive review on natural selection acting in viral sensors in vertebrates: sciencedirect.com/science/ar…
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Tobias L Lenz retweeted
Randy Nesse
@RandyNesse26 Feb 2024
This Friday is the deadline for submitting abstracts for posters, talks and symposia for ISEMPH 2024! The world's premier evolutionary medicine meeting. Q to [email protected] isemph.org/abstracts2024 @ISEMPH @sse_evolution @eseb_org @EHBEA1 @evmed_ch @TriCEM_NC @wellcometru
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Does the immune system protect against cancer? Today our study on HLA immunogenetics and lung cancer risk has been published in @ScienceMagazine led by @chirag_msk @AnniinaTervi @MiriamSaffern @EricWil39327976 @HannaMOllila @rsamstein science.org/doi/10.1126/scie…

An immunogenetic basis for lung cancer risk

Genomic and epidemiological analyses reveal that HLA class II heterozygosity is associated with a reduced risk of lung cancer in smokers.

science.org
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Look at the all-star lineup of keynote speakers at SMBE's upcoming annual meeting in Puerto Vallarta, Mexico! 🇲🇽🌴😎 @AliciaMstt, @AidaAndres, @ScottVEdwards1, and @stepheniwright. Don't forget to send your abstracts before March 15th 👉 smbe2024.org/ @OfficialSMBE
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Come work with us: #PhD position available in our lab to study evolutionary genetics of adaptive immunity in humans and/or fish. We use computational and molecular approaches. Topic open, to be matched with student's interest/skills. #MHC #HLA #TCR uni-hamburg.de/en/stellenang…
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Wow 🤩 It feels like I discovered a secret blue island 🏝️ what is this place? 🦋 let’s meet over there?! 👉🏻
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Tobias L Lenz retweeted
Waggoner Lab@LabWaggoner30 Nov 2023
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution @soumya_boston @joycebkang nature.com/articles/s41588-0…

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Nature Genetics - scHLApers is an analysis pipeline that quantifies single-cell expression of HLA genes using a personalized genomic reference. Mapping of HLA expression quantitative trait loci at...

nature.com
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Very proud to see @the_MRCA defend his #PhD thesis on #HLA immune gene diversity and evolution in modern and ancient human populations! I'm biased, but I do think it's very exciting work! Looking forward to see also his last two chapters out soon! @MPI_EvolBio @UHHBio
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New paper out in @molecology! Molecular ecology of microbiomes in the wild: Common pitfalls, methodological advances and future directions onlinelibrary.wiley.com/doi/…

Molecular ecology of microbiomes in the wild: Common pitfalls, methodological advances and future...

The study of microbiomes across organisms and environments has become a prominent focus in molecular ecology. This perspective article explores common challenges, methodological advancements, and...

onlinelibrary.wiley.com
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Tobias L Lenz retweeted
Shai Carmi@ShaiCarmi30 Nov 2023
Important analysis of the underrepresentation of Arabs in genome-wide association studies. A few comments. 1. We expect the situation to somewhat improve, at least for Arab Israelis, with the developing Israeli national biobank project. ->
Akl Fahed
@aklfahed29 Nov 2023
New in @GenomeMedicine led by @RomitB_MD and NingNing Chen Massive underrepresentation of Arabs in genomic studies of common disease rdcu.be/drNGy / thread
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Amazing meeting @FU_Berlin featuring top experts in #MHC antigen presentation and its translational implications. Thank you Christian Freund and Miguel Alvaro-Benito for the great opportunity of interdisciplinary interaction, also for our PhD students! @MedEssen @UniklinikEssen
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Tobias L Lenz retweeted
Kaitlin Samocha@ksamocha1 Nov 2023
It's here~! Just in time for #ASHG23. gnomAD v4: publicly available data from >800k sequenced individuals on GRCh38.
Genome Aggregation Database@gnomad_project1 Nov 2023
The #gnomAD team is proud to announce the release of gnomAD v4! The v4 dataset includes 730,947 exomes & 76,215 genomes, which is ~5x larger than the v2 & v3 releases combined, & includes nearly 120K indivs of non-European genetic ancestry broad.io/gnomad_v4 #ASHG23 (1/11)
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I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritc…
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