@heewlim

Associate Professor @ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center. All personal opinions

computbio.org
Joined April 2016
  • Tweets289
  • Following497
  • Followers212
10Media
I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.
2
10
19
1,407
Happy to share the final version of our paper describing that the widely used Ucp1-CreEvdr transgene unfortunately elicits complex developmental and metabolic phenotypes. This work was mainly driven by @ManasiHalurkar (now a PhD student at Purdue). nature.com/articles/s41467-0…

The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes

Nature Communications - UCP1 is involved in regulating thermogenesis, and the Ucp1-Cre mouse line has been widely used for studying brown fat. Here they show that this mouse line carries an extra...

nature.com
1
7
2
51
3,232
My bluesky account
30
Hi everyone!!! We are excited to re-introduce ourselves as the PhD Program in Development, Stem Cells, & Regenerative Medicine (DSRM) at Cincinnati Children’s! (formerly Molecular and Developmental Biology). Stay tuned for more info on applying to our program🎉🧬!!
4
13
1,110
We're honored to once again been named to @usnews Best Children’s Hospitals Honor Roll for the 2024-25 rankings. We ranked No. 1 in three specialties, and we placed in the top 10 for all 10 ranked specialties - cincinnatichildrens.org/news…
208
77
17
184
36,191
Hee-Woong Lim retweeted
Jason Yang@JasonJuechen30 Aug 2024
First peer-reviewed paper during my PhD journey: science.org/doi/full/10.1126… Welcoming comments and feedbacks

Accelerating drug discovery and repurposing by combining transcriptional signature connectivity...

Drug discovery can be accelerated by combining transcriptomic signature connectivity analysis with targeted docking simulations.

science.org
2
2
3
9
1,153
Hee-Woong Lim retweeted
Prasath Lab@PrasathLab28 Aug 2024
📣 Review of DL techniques for multimodal spatial transcriptomics analysis. Work by @pankajrajdeo01 from @CincyInformatix. doi.org/10.1016/bs.acr.2024.… Collaborative work under the mentorship of @brucearonow, @CincyResearch. H/T and thanks to Dr. @heewlim🙏 #AI #transcriptomics
2
2
256
Another beautiful method paper from the Koo lab: rdcu.be/dKtlO
4
21
1,710
Our Human Bone Marrow CITE-Seq Portal (altanalyze.org/MarrowAtlas/) now hosts video and step-by-step walk through tutorials for: 1) Supervised scRNA-Seq annotation (Azimuth) 2) Comparative visualization of RNA & ADTs (ShinyCell). Please see the on-page and Synapse download links.
2
19
45
6,651
Many thanks to @MucosalImmunol for this honor! Enjoyed working with @baileydidriksen and @emeshlem on this review discussing how #epithelial sensing of the #microbiota can direct immune responses #mucosalimmunology #everycellisanimmunecell
Mucosal Immunology@MucosalImmunol15 Mar 2024
Our latest #EmerginLeaderinMI is Theresa Alenghat @AlenghatLab. Read her review on "Epithelial regulation of microbiota-immune cell dynamics" online now: mucosalimmunology.org/articl…
6
1
34
3,704
My best article @ScienceMagazine. It took ~1 year for me to publish it since its 1st submission. I hope it will positively change the #culture. I hope you will work together with me to make a better world for the next #generations. Please retweet broadly. science.org/content/article/…

How I overcame my anxiety to achieve my purpose as a professor

“I learned to spend more time trying than worrying,” this scientist writes

science.org
73
286
85
992
422,573
Hee-Woong Lim retweeted
Mingxia Gu@MingxiaGu8 Feb 2024
Thrilled to unveil our latest endeavor: crafting vascularized lung, intestine, and colon organoids with organotypic endothelial and mesenchymal cells via a mesoderm-endoderm co-differentiation approach. Huge thanks to our collaborators @CuSTOMOrganoids @Kottond @YaWenChenMSSM
6
11
2
65
11,148
Can mutant splicing factors programs exist in the absence of mutations? In our new preprint bit.ly/3SBqZSX with @LeeGrimesLab @dstarczynowski @Amitvermamds, we show these programs exist broadly in AML, impact LSC survival and can be reversed. #OncoSplice #PRMT5 #IRAK4
1
18
2
45
5,965
Pleased to share our new study @ImmunityCP led by Dr. Emily Eshleman @emeshlem on tuft cell regulation in the intestine. Many thanks to our wonderful collaborators on this project! cell.com/immunity/fulltext/S…

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to...

Tuft cells are central regulators of type 2 immunity in the intestine. Eshleman et al. reveal that commensal bacterial-derived butyrate restricts stem cell development into tuft cells through the...

cell.com
7
30
4
104
13,521
Cincinnati Children's is a cradle of discovery! Our new Research Annual Report showcases a year of innovation fueled by record-high funding. From FLASH #ProtonTherapy to driver safety training for teens with #ADHD, we're improving outcomes together: scienceblog.cincinnatichildr… #RAR23
2023 Research Annual Report Cover

ALT 2023 Research Annual Report Cover

12
2
30
3,883
(1) We are excited to finally share “Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy” at Science Translational Medicine (bit.ly/4b23Gdq). SNAF is an end-to-end workflow for splicing neoantigen & transmembrane epitope prediction...
8
9
1
31
4,368
Online Now: Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate dlvr.it/T1CDSD
32
2
127
19,814
Very happy to see this four-year collaborative work with Iwafuchi lab is finally published in @MolecularCell "Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate" @CincyChildrens sciencedirect.com/science/ar…
2
15
52
11,512
CCHMC Science Blog scienceblog.cincinnatichildr…

How ‘Pioneers’ Blaze the One Trail that Determines Cell Fate - Research Horizons

Cincinnati Children’s scientists shed light on how a special set of transcription factors ride herd on developing tissue.

scienceblog.cincinnatichildrens.org
2
164
Load more