Associate Professor of Medicine @UVADOM | Internal Medicine | Medical Director UVA Health EDS Center | CMO @EhlersDanlosSociety | AI | @USAirForce Veteran
Charlottesville, VA
Joined April 2009
- Tweets2.8K
- Following873
- Followers1.2K
- Likes7.6K
Interested to see how this pans out; could be good, but still a long way to go for chronic conditions and the mechanism/substrate question
I left @Apple to build healthcare that listens and acts early. Today, I'm excited to introduce UniqueHuman.
We're building proactive healthcare agents that handle every step of care for people with chronic conditions.
Our mission is to end chronic suffering. Today, we begin with migraines.
Will not and *should* not 👍
"Why Doctors Will Not Be Replaced: The Future of Humanistic Medicine in an AI-Driven World." Thanks to Gastro Learning Network for covering my keynote talk from last week's @AmCollegeGastro annual meeting: hmpgloballearningnetwork.com… #ACG2026
Dacre Knight, MD, MS, FACP retweeted
In the last year or so, in talks & podcasts, I predicted this AI-bio-autolab-digital twin loop as a key pillar for solving all diseases & reversing aging in 10-15 years. “Experts” called it unrealistic & impossible in such a short time. Turns out I may have been conservative.
We are bringing agents to the wet-lab bench at Google Research to navigate complex biological landscapes. Learn how we are grounding agents in physical lab robotics to run fast closed-loop molecular design cycles, ultimately discovering single-digit nanomolar protein binders for cancer targets →goo.gle/4B5mMMB
Getting the targets right, a menopause review science.org/doi/10.1126/scie…
Like ripping off a band-aid? What can go wrong… Utah will become first state to let AI examine patients and prescribe medication without direct human oversight techspot.com/news/114111-uta…
An advancement in academic publishing, and possible answer to ai paper mills
When your research paper can talk to you and interact with other research papers....
Reimagining science publishing and knowledge dissemination with Paper2Agent
nature.com/articles/s41586-0…
@nature @james_y_zou @Jiacheng_Miao
Dacre Knight, MD, MS, FACP retweeted
The Case for UFOs Is Weaker Than Ever, by @RichardHanania. "The fact that we talking apes can extract any information at all from objects billions of light-years away – even that we have the concept of a light-year! – should fill us with awe and wonder. It should offend one’s sense of rationality to still see people, in the year 2026, act as if “trust me bro” counts as real evidence, in contradiction to everything we have learned about how to increase human knowledge." open.substack.com/pub/richar…
Dacre Knight, MD, MS, FACP retweeted
“The last thing I want when I’m trying to Hispanicize myself is for Puerto Ricans to Anglicize me. In Puerto Rico, I am Juan. Or, as I prefer to say, me llamo Juan.”
Me on my first couple of months in Puerto Rico: windsormann.substack.com/p/i…
I had the honor of bringing Jill to speak at our seminar at Mayo Clinic; her legacy lives on.
If you read or listen to one thing today, let it be the story of Jill Viles, #EmeryDreifuss #MuscularDystrophy patient advocate and researcher who self-diagnosed herself and her father at age 19 and sadly passed away last month at age 50, as told on @ThisAmerLife: lnkd.in/dCGX7vgF
Unbelievably, Jill helped diagnose Canadian Olympic sprinter Priscilla Lopes-Schliep—whom she'd never met—with another #RareDisease they shared, #lipodystrophy. Her life is a testament to patient advocacy and patient power in research. We extend our condolences to Jill's loved ones and everyone touched by her story.
ALT Photo of Jill sitting in the surf at the beach, smiling, next to Priscilla running in the Olympics. Jill's muscles are minimal due to her muscular dystrophy, but Priscilla's are like that of a body-builder. The title of the This American Life episode, Something Only I Can See, is shown with the caption, "When you’re the only one who can see something, sometimes it feels like you’re in on a special secret. The hard part is getting anyone to believe your secret is real. This week, people trying to show others what they see—including a woman with muscular dystrophy who believes she has the same condition as an Olympic athlete." Read the episode transcript or listen to it in full at the link in bio.
New location for therapy targets of chronic pain? Mu opioid receptors gate the locus coeruleus pain generator: Current Biology cell.com/current-biology/ful…
We are hosting a PT/OT symposium in October in Charlottesville @UVaCME @UvaDOM, inviting all healthcare professionals and rehab specialists interested in learning more about EDS and HSD. In-person only. uva.cloud-cme.com/course/cou…
Dacre Knight, MD, MS, FACP retweeted
In the U.S., the single best predictor of being a supercentenarian is not having a birth certificate.
82% of American supercentenarian records predate statewide birth certification.
When a state hit full coverage, its supercentenarian count dropped about 80% per year.
Great show, I learned a lot; glad to be a part of it!
What’s making health headlines? On our Aug. 1 Roundtable: glucosamine and Alzheimer’s risk, Gen X aging, Galleri cancer screening, off-label GLP-1 use and telehealth abortion care.
With @UVADom @Knidac, @MayoClinic @TinaArdon,@MayoClinicNeuro Dr. Draz and @yourgyneguru.
@wjctnews @fcconair @CarlyAKramer @heatherschatz
Dacre Knight, MD, MS, FACP retweeted
Our perspective on decision authority in health AI was just published at @Nature Health, w/ Aiden Gu
free access rdcu.be/fwDdv
nature.com/articles/s44360-0…
If black holes were illuminated
Using more than 1.4 petabytes of electron microscopy (EM) imaging data, researchers generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, providing an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels.
The human brain is a vastly complex organ and, to date, little is known about its cellular microstructure, including the synaptic and neural circuits it supports. Disruption of these circuits is known to play a role in myriad brain disorders. Yet studying human brain samples in such great detail comes with a host of challenges, ranging from technological limitations to the availability and preservation of tissue samples from healthy individuals.
In a 2024 Science study, researchers performed a high-resolution EM reconstruction of the ultrastructure of a cubic millimeter of human temporal cortex. According to the authors, the reconstruction contains roughly 57,000 cells, about 230 millimeters of blood vessels, and nearly 150 million synapses, comprising 1400 terabytes of data. The authors generated a three-dimensional reconstruction of nearly every cell and process in the cubic millimeter sample and developed a freely available tool for visualizing and analyzing the vast dataset.
Learn more on #WorldBrainDay: scim.ag/41z2OJ4
Dacre Knight, MD, MS, FACP retweeted
The heart has a mysterious and complex nervous system of its own. Scientists are starting to reveal its secrets
go.nature.com/4vEZnO7
