@renesugar
 Earth
linktr.ee/rene.sugar
Joined March 2009
  • Tweets178K
  • Following4.5K
  • Followers4K
14.4KMedia
Rene Sugar retweeted
News Medical@NewsMedical11h
Semaglutide doesn't just curb appetite - it changes gut bacteria in ways eating less can't explain 🧫🐀. Dive into the surprising microbiome shifts seen in both male and female rats: news-medical.net/news/202610… #Semaglutide #Microbiome
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Replying to @bhanlon15
I’ve seen success in amelioration of fatigue with higher dose valacyclovir twice a day a subset of patients w MS or long covid/Neurocovid. Pts w hx of EBV/mono esp. pmc.ncbi.nlm.nih.gov/article… pmc.ncbi.nlm.nih.gov/article…

Treatment of Long-Haul COVID Patients With Off-Label Acyclovir

The SARS-CoV-2 virus (COVID-19) became a global pandemic in March 2020. This novel, highly infectious virus caused millions of infections and deaths around the world. Currently, there are few...

pmc.ncbi.nlm.nih.gov
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Rene Sugar retweeted
Lucas Pontel@LucPontelOct 26
Cells make toxic metabolites every minute they’re alive. How do they survive them? In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇 science.org/doi/10.1126/scia…

NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formald...

Cancer cells must balance detoxification of reactive metabolic by-products while preserving redox homeostasis, but how this trade-off is managed remains unclear. The Kelch-like ECH-associated protein...

science.org
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Identification of hACE2-interacting sites in #SARSCoV2 Spike Receptor Binding Domain for Antiviral Drugs Screening #MECFS #LongCovid sciencedirect.com/science/ar… "Moreover, Cefixime inhibited live SARS-CoV-2 infection."
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Molecular docking and dynamic simulations of Cefixime, Etoposide and Nebrodenside A against the pathogenic proteins of SARS-CoV-2 sciencedirect.com/science/ar…
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Celiac disease manifested by polyneuropathy and swollen ankles #MECFS #LongCovid pmc.ncbi.nlm.nih.gov/article…

Celiac disease manifested by polyneuropathy and swollen ankles

A 27-year-old male started to have his ankles swollen during his military service. He was examined at a military hospital where electromyoneurography showed the signs of distal sensory-motor polyne...

pmc.ncbi.nlm.nih.gov
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A new oral peptide called Icotrokinra completely cleared psoriasis in 27% of patients after 16 weeks. And 50% saw at least 90% improvement. All from a once-daily pill!
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Circulating cholesterol fuels #SARSCoV2 replication via ORF3a #MECFS #LongCovid link.springer.com/article/10…

Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a

EMBO Reports - High levels of “bad” cholesterol increase the risk of cardiovascular disease and are also linked to more severe COVID-19, though the reason has been unclear. We show that...

link.springer.com
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Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes nature.com/articles/s41392-0…

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Signal Transduction and Targeted Therapy - Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

nature.com
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SARS-CoV-2 can directly link its replication to host cholesterol levels via ORF3a link.springer.com/article/10…

Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a

EMBO Reports - High levels of “bad” cholesterol increase the risk of cardiovascular disease and are also linked to more severe COVID-19, though the reason has been unclear. We show that...

link.springer.com
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Rene Sugar retweeted
Science News
@ScienceNewsOct 25
Viruses may be minuscule, but one could have influenced major differences between human and chimpanzee brains. sciencenews.org/article/huma…

Why did humans' brains surpass chimps'? A tiny foe might help explain it

A viral infection from millions of years ago may have influenced chimp brain evolution through DNA leftovers in the genome.

sciencenews.org
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Rene Sugar retweeted
ScienceAlert
@ScienceAlertOct 25
A possible culprit hiding around the urethra could help explain the most common prostate problem in men over 50. 🔗 sciencealert.com/scientists-…
Scientists May Have Discovered Why Men's Prostates Enlarge With Age

ALT Scientists May Have Discovered Why Men's Prostates Enlarge With Age

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Could a bladder medicine choice matter for brain health? In older women with overactive bladder, anticholinergic meds were linked to a 49% higher risk of claims-defined dementia vs β3-agonists. No difference in long-term care needs or frailty. What brain-health meds have you heard about lately?
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Doctors learned inflammation could change mood by accident in the 1980s. Interferon alpha was used for chronic hepatitis, and some people on the highest doses quickly developed depression, agitation, emotional swings and even paranoia. Lowering the dose made the psychiatric side effects go away. That history still explains sickness behavior today. When you fight a virus you get tired, irritable and want to be left alone, which is a useful short term response. The problem is when those same signals stay on for months. TNF and IL6 variants are part of why some people seem more sensitive to that shift. 👇 geneticlifehacks.com/is-infl…

Can Inflammation Cause Depression? Genes and Solutions

Inflammation can cause depression and anxiety. See which cytokines and gene variants raise your risk, and research-backed ways to lower inflammation.

geneticlifehacks.com
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virus.sucks/blog/pluslife_ne…

Pluslife News: October 2026

Altruan now ships the PM001 Ultra, test results can be shared and watched live through a link, and Pluslife is preparing OTC tests for Europe.

virus.sucks
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Karolinska Institutet researchers found that SARS-CoV-2 infection accelerated lung tumor growth in mice by triggering low oxygen, inflammation, and VEGF-driven blood vessel formation. Blocking VEGF significantly reduced tumor growth. nature.com/articles/s41392-0…

COVID-19 triggers pulmonary tumor outgrowth through hypoxia- and inflammation-induced VEGF-depend...

Signal Transduction and Targeted Therapy - COVID-19 triggers pulmonary tumor outgrowth through hypoxia- and inflammation-induced VEGF-dependent angiogenesis

nature.com
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Rene Sugar retweeted
John Lukens@LukensJohnROct 24
TIA1 is required for microglial activation in tauopathy: @CellReports cell.com/cell-reports/fullte…

TIA1 is required for microglial activation in tauopathy

Webber et al. find that the RNA-binding protein TIA1 promotes microglial activation and tau pathology in a mouse model of tauopathy. This study also shows opposing regulatory roles of TIA1 in central...

cell.com
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Rene Sugar retweeted
Waggoner Lab@LabWaggonerOct 23
Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages @CellCellPress cell.com/cell/fulltext/S0092… @VishwaDeepDixi1 @Yale
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Glioblastoma breakthrough reveals how brain cancer cells become more aggressive sciencedaily.com/releases/20…

Glioblastoma breakthrough reveals how brain cancer cells become more aggressive

Scientists discovered that the thick, sticky fluid surrounding glioblastoma tumors can make brain cancer cells smaller, more flexible, and better at invading surrounding tissue. Even more troubling,...

sciencedaily.com
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Rene Sugar retweeted
Waggoner Lab@LabWaggonerOct 24
NAD+ metabolic restoration resolves the inflammation-immunocompetence trade-off in lung graft-versus-host disease science.org/doi/10.1126/scia… @ScienceAdvances 🇨🇳
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