Aspiring physician-scientist, Cardiology Fellow at UPenn. Member of the Arany Lab Sarnoff Alumni. AECOM alumni.
Joined June 2022
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Grateful to have worked with such a dedicated team in the @AranyLab and @MarguliesLab to bring this discovery to fruition. And thanks @SarnoffCardio for all your support!
We've not understood why SGLT2 drugs (like empagliflozin, Jardiance) have marked protective heart benefit.
Today @ScienceMagazine a mechanism unraveled for improving cardiac metabolism and fuel efficiency
science.org/doi/10.1126/scie…
Nicholas Forelli retweeted
It's almost as if NIH has been taken over by rouge ideologues. Drastic cuts in indirects are like cutting off your nose to spite the face. For mere $4B in "savings," this will end the dominance of American research universities, the best damn value for American tax payers. And when did doing life-saving medical research & providing care to the neediest make you a dinosaur?
Nicholas Forelli retweeted
Now out in @JAMA_current: How well do individual risk estimates from different CHD polygenic scores agree? Grateful to work on this with a dream team of mentors and co-authors @damrauer @MGLevin @bpasaniuc @MarylynRitchie @dokyoon_kim @bvoight28 @BoulierKristin @karlkeat
🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star @SarnoffCardio fellow @sabramowitz_:
jamanetwork.com/journals/jam…
Nicholas Forelli retweeted
Are you an MD student interested in research?
Would strongly consider applying for the @SarnoffCardio Fellowship. Scientific immersion with *unparalleled* longitudinal mentorship & exceptional peer network career-long. sarnofffellowship.com/
My biggest regret in med school was not participating despite guidance from mentors. Now I'm thrilled to join this vibrant community on the Scientific Committee.
Nice summary of the program ahajournals.org/doi/10.1161/… @CircAHA
Track record of successful physician-scientists going through this program is impressive - the recipe of immersion + longitudinal engagement/sponsorship/mentorship works very well
Our Story is Out - on BioRxiv! Humbled to have worked with such a great team of scientists to investigating how #SGLT2 inhibitors provoke their astounding cardiac benefits.
We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.1101/…
Nicholas Forelli retweeted
So proud !! congratulations Megan and Quentin -- newest Aranylab graduates. Watch out world, here they come! @MeganCBlair @CAMBUpenn
Nicholas Forelli retweeted
Very proud of @CampainJoseph, outstanding Sarnoff Fellow in my lab this year from UTSW @josephahill who just presented his work on O2 kinetics in HFpEF compared to a community cohort at the 43rd Annual Sarnoff Scientific Meeting . @Raj_MalhotraMD @MGHHeartHeath @MGHMedicine
Nicholas Forelli retweeted
11 clinical trials that will shape medicine in 2023.
Part of our Year in Review, written by @edbites and Paul Webster
nature.com/articles/s41591-0…
Nicholas Forelli retweeted
What happens to non-cardiomyocytes in the heart with aerobic exercise? Check out our new review paper in @JSHS_MedHealth from the @rosenzweig_a lab @lihaobo @JSawallaGusehMD @sashalkuznet
+1K. What is the cellular cardiovascular response to exercise? Great in-depth review by @LenaETrager on the diversity of cellular response to exercise within the heart.
Full Review: buff.ly/3HON5O6
cc: @lihaobo @rosenzweig_a @sashalkuznet
Nicholas Forelli retweeted
I don’t usually brag about our residency program, but today I’m gonna make an exception.
Like other children’s hospitals, we’re managing a surge in respiratory illness.
But unlike most hospitals, we’re gonna pay the residents who work extra overnight/weekend shifts $100/hour.
Barry Sharpless with his second Nobel in chemistry!
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Nicholas Forelli retweeted
Interested in heterologous expression of large numbers of biosynthetic gene clusters?
My focus over the past years has been to try to make this process more scalable.
Have a look at this new approach, I used it to discover a new antibiotic: conkatamycin
nature.com/articles/s41467-0…
Nicholas Forelli retweeted
Modeling Heart Failure with Preserved Ejection Fracion (HFpEF) in Rodents: Where do we stand?
>3 million in US suffer from it. Accurate preclinical models are critical to develop new drugs. This review by @MTChinMDPhD sets the framework. @FrontDrugDDS
frontiersin.org/articles/10.…
Nicholas Forelli retweeted
It’s a special kind of joy when you see your cardiomyocytes beating for the first time 🥰 #SarnoffYear #CardioTwitter #WomenInSTEM
