UF MD/PhD. PhD Neuroscience. Neurobio/Neuroimmuno/Metabolism/Stress Biology. Artist formerly known as Dr. Love/Pre-Med Guy. š¤.
80 Miles From Santa Fe
Joined January 2011
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This is just soul crushing.
#HIV service delivery after the #PEPFAR and USAID HIV funding withdrawal in Uganda and Zimbabwe: an interrupted time-series study - first real-world, quant evidence showing drops in HIV service delivery following the USG foreign aid freeze and stop-work orders @LancetGH thelancet.com/journals/langlā¦
I donāt see a community noteā is this real?
US energy company execs have resigned in disgust as the Trump family is caught secretly expediting the funneling of $25 billion from a sanctioned Russian energy giant in exchange for allowing Russians to obtain a natural gas project in Alaska.
According to investigations by The New York Times and Financial Times, Russia's Novatek allegedly concealed its financial involvement in the American project through a UAE-linked intermediary.
Gentry Beach, a longtime Trump ally and close friend of Donald Trump Jr., signed an agreement with Novatek to pursue natural gas development in Alaska. Reuters documented the arrangement in February.
Meanwhile, Vladimir Putin discussed this cooperation on the Alaska energy project with Trump's representatives, Steve Witkoff and Jared Kushner, during negotiations involving Russia and Ukraine.
The controversy deepened when Polar Train LNG's CEO, Joel Riddle, raised concerns about concealed Russian financing and possible sanctions violations. He departed in September, followed by other senior executives.
The Financial Times also described discussions about a potential arrangement under which Novatek would provide technology for the Alaska project in exchange for sanctions relief benefiting its Arctic LNG 2 development in Siberia.
According to The New York Times, Riddle and two other departing executives warned the Trump administration about the Russian financing and urged officials to investigate.
The White House maintains that the project was mentioned only briefly and that no detailed discussions took place. There is no established evidence that Kushner or Witkoff knew about the allegedly concealed financing. Polar Train LNG denies wrongdoing.
The central question is how a sanctioned Russian energy company became involved in a major American energy venture while Putin was discussing potential economic cooperation with Trump's representatives and a longtime Trump family associate was pursuing a separate agreement with the same Russian company.
Selling Alaska to the Russians or selling Ukraine to the Russians - to the Trump family it's all the same.
ft.com/content/e9cfbfbb-e65aā¦
I honestly have no idea what the point of these types of discussions are if
A) they get endlessly clipped as the means of dispersal
B) everything is litigated on Twitter threads after the fact
C) the actual gripes are addressed in said Twitter threads.
"'It's fair to have a debate,' you wrote, 'about the best direction of the party, but that debate should be conducted on honest terms.' I read that and I think: You're not being honest here, Matthew. Comparing El-Sayed to Cooper and Peltola is not just disingenuous; it's apples and oranges."
Latest clip/exchange from my interview with @mattyglesias on whether centrists like him and Neera Tanden are trying to apply unfair metrics/expectations/comparisons to @AbdulElSayed, whose race is sui generis.
Clip below.
Watch the full interview: zeteo.com/p/matt-yglesias-meā¦
First time Iāve stopped and thought everyone should hit the brakes HARD on the model development. No amount of regulation can really cap this level of ingenuity if real.
Over the past several months, we have substantially hardened the security of our research training environment. Weāve removed live internet access for all frontier models during training and built an offline world for them to use insteadāa cached version of the web where they can still learn to browse, search, and use applications.
On September 20, after a model exploited a DNS misconfiguration to find a way outside of this offline world, we paused frontier training to strengthen containment further. We assembled teams of agents, powered by our most cyber-capable models, and tasked them with finding weaknesses in our research environments.
While they found no route to the internet they could easily exploit while concealing their activity from our monitors, they did find zero-day vulnerabilities, virtual machine escapes, and hardware side-channels for communication between agents. We used their discoveries to further strengthen our defenses and contribute fixes to open-source software.
After strengthening our containment architecture, we resumed our frontier RL training and inference on October 1. Weāve reserved substantial compute for continuous red-teaming, and made high-compute red-teaming part of the safety cases we use to decide whether frontier training and evaluation can proceed securely.
openai.com/index/securing-ouā¦
The taurine pendulum swings once again.
Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages @CellCellPress
cell.com/cell/fulltext/S0092ā¦ @VishwaDeepDixi1 @Yale
šZK For Treš retweeted
Research Article by J Du et al. #Exercise-mimicking effect of #exogenouslactate administration: promoting #visceralfat reduction via #ventromedial #hypothalamic SF-1 #neurons in female rats
ow.ly/5ZYy5100t66
Credit to the trialists for a really good execution here, but not mentioning the intermittent fasting component was the only part designed to result in a caloric deficit is a bit of a hand wave, no?
New @Cell_Metabolism on benefit of intermittent fasting in overweight individuals with metabolic syndrome
A randomized trial showed that the Mediterranean diet, while reducing lipid abnormalities, did not suppress inflammation until intermittent fasting was added
cell.com/cell-metabolism/fulā¦
It isā¦ not great that they are just becoming familiar with lab timelines.
Wait until they hear about clinical trial timelines.
Where do you go next after reporting from the Strait of Hormuz? For the past three months, Citrini Research, an independent research firm, has been working with our team and an internal research model to see if they could use AI to create a new drug. What follows is an entertaining, candid, and humbling account of a group of motivated nonexperts (or āfilthy casualsā, as Citrini would say) trying to tackle a real problem in human health with Claude.
We landed on scorpion neurotoxins, which kill over 3,000 people a year. Of the 211 designs we produced and tested, 17 met our criteria for a binder. None of the designs bound more than one toxin and none have been tested for neutralizing a toxin.
One of my favorite quotes from the piece is: āOur virtual biologist may have compressed a year's worth of work into a couple days, but biology works at the speed of lifeā¦Over two days, we watched Claude work through problems at a speed that was difficult to comprehend. For the next two months, we spent much of the time becoming familiar with laboratory turnaround times (This mostly involved sending memes in Slack).ā
I donāt know a lot of residents that only work 65 hours per week, either.
I'm not saying residents should be paid like attendings. I'm saying the math deserves to be said out loud.
$66,712 divided by roughly 3,380 hours a year is about $20 an hour, before taxes and before the student loans keep growing in the background.
If you're in training right now: your income will change. Your habits won't unless you decide they will.
What did your hourly rate work out to in residency?
In training? My free live lecture series starts in January. Save your spot with the link in my bio.
