#stemcells researcher | Director of Cell Processing Facility @umontpellier @CHU_Montpellier | #iPScells #lung | @stemgenomics

Montpellier, France
Joined July 2009
John De Vos retweeted
Just published @ScienceMagazine Higher medical accuracy at lower cost A 3-agent AI for sequential diagnosis nearly doubled accuracy compared with physicians for >300 @NEJM CPC cases and >300 ER cases AND substantially lowered cost, also exceeded performance of many AI models, physicians plus AI @HarshaNori @erichorvitz @Dominic1King @mustafasuleyman
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John De Vos retweeted
This is 100% correct.
I don’t think Europeans fully appreciate what is happening to the European Union right now. The EU is under an extraordinary, multi-front assault, both from outside and from within. And I struggle to think of another period in its history when so many powerful actors had an interest in weakening it simultaneously. Russia has spent years waging hybrid warfare against Europe. Weaponised migration, sabotage, cyberattacks, coordinated disinformation campaigns, bot networks and political interference. The objective is clear: undermine trust in democratic institutions, deepen social divisions and weaken European unity. China has different motivations, primarily economic and geopolitical. A fragmented Europe is easier to pressure, easier to negotiate with individually and less capable of defending its economic interests. And then there is the United States. Perhaps the most disturbing development of all. Under Trump and MAGA, a country that helped rebuild the old continent and then spent decades supporting European integration now has an administration openly hostile to much of what the EU represents. Its own National Security Strategy even calls for cultivating resistance to Europe’s current political direction. Think about that for a moment. Meanwhile, within Europe, parts of the far right and far left amplify these divisions, whether through ideological alignment, political opportunism or outright sympathy for authoritarian regimes. This doesn’t mean Russia, China and MAGA are all following some jointly coordinated master plan. They don’t have to. Their interests increasingly overlap, and Europe’s internal divisions make their work considerably easier. What makes this particularly alarming is what is actually at stake. For all its flaws, the EU remains one of the world’s most consequential projects built around liberal democracy, the rule of law, individual freedoms and cooperation between nations. At a time when authoritarianism is gaining ground and even longstanding democracies are showing disturbing tendencies, that matters enormously. Europe is far from perfect. Its bureaucracy, indecision and inability to act decisively are real problems. But the answer cannot be to retreat into 27 competing nation-states, each too small to meaningfully influence a world increasingly dominated by continental powers. Quite the opposite. Europe needs deeper integration, stronger common institutions, genuine strategic autonomy and the political courage to defend its interests and values. Because fragmentation is precisely what so many external actors want. And perhaps that’s the central irony of our time: people are being deliberately manipulated into believing that the reverse is true — that national identity and sovereignty can only be protected by weakening European cooperation. In reality, a divided Europe is less sovereign, less secure and far easier for outside powers to pressure. Therefore the very thing that will make Europe stronger is the thing its adversaries are working hardest to prevent. A united Europe is a geopolitical power. A divided Europe is a collection of countries waiting to be played against one another.
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Celebrating 20 years of iPSC research! 🧫✨ Join us in honoring two decades of induced pluripotent stem cell progress and the researchers advancing the field. Attending #ISSCR’s iPSC 20th Anniversary Symposium in Kyoto? Come celebrate with us! Not attending? Explore key milestones and see where human iPSC research is heading next: bit.ly/4yL9DXz
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Great news for pulmonary fibrosis patients, families, researchers, clinicians. @bmsnews announces that in phase 3 RCT ( peer reviewed yet), Amilparant, an inhibitor of the LPA receptor, has met primary endpoint! Wow!!! #CurePF4All #BeLikeAndy news.bms.com/news/corporate-…
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John De Vos retweeted
🌐 AI for science just became science diplomacy. On October 4, the US and 16 other countries, including Japan, South Korea, the UK, Germany and Singapore, endorsed the "Kyoto Vision for a Golden Age of Science" at the STS Forum in Kyoto. I only learned about it today, from a friend. In case you missed it too, here is the short version. 💡 The one-page text covers a lot of what I care about. More diverse funding, from long-term awards to fast grants and prizes. Room for new institutional models. Metascience and reproducibility. AI for science, including autonomous closed-loop discovery. Early investment in young talent. Much of this I support. Closed-loop, AI-driven experimentation is at the core of what we do in the Theis lab, and funding systems everywhere could use more experimentation themselves. The declaration builds on the White House report "Science: A New Golden Age" from July, which goes further, for example in rethinking the role of universities. Not trivial. How these ideas translate will differ between national systems. Germany's research ministry, for instance, calls the paper a non-binding basis for discussion and stresses that freedom of research and the independence of science remain non-negotiable. 🌍 For me, the test will be concrete: shared access to compute, data and automated labs, and collaboration across borders. Researchers should help shape what this means in practice. How do you see it? Will it change how science is funded where you work? 🇩🇪 BMFTR statement: bmftr.bund.de/SharedDocs/Kur… 📄 Kyoto Vision: bmftr.bund.de/SharedDocs/Dow… 📘 Science: A New Golden Age: whitehouse.gov/wp-content/up… 🇺🇸 White House release: whitehouse.gov/releases/2026… #AIforScience #ScienceDiplomacy #Metascience
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John De Vos retweeted
How much do PhD students earn? The first comprehensive overview of PhD income shows vast imbalances across much of Europe Read the full story: nature.com/articles/d41586-0…
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Similarly, Cellectis is shifting its focus from ex vivo allogeneic #CART cells therapies to in vivo CAR-T approaches. fiercebiotech.com/biotech/ce…
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Recent safety events with Novartis and BMS highlight the challenge of translating #CART from life-threatening cancers to chronic autoimmune diseases Meanwhile, Kyverna’s miv-cel continues to show encouraging efficacy and safety in stiff person syndrome biospace.com/drug-developmen…
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John De Vos retweeted
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Century Therapeutics’ Allo-Evasion™ 5.0-edited CNTY-813 (#iPSC-derived islets) showed durable glycemic control in diabetic animal and clinical-scale manufacturing. IND submission planned for Q4 2026, with first clinical data expected in 2H 2027. markets.businessinsider.com/…
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BlueRock Therapeutics’ #iPSC-derived cell therapy lemiretprocel (OpCT-001) has received orphan drug designation from both the FDA and EMA for inherited retinal diseases. Now in Phase 1/2a testing. bluerocktx.com/bluerock-ther…
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John De Vos retweeted
Ezra Klein asked Bill Gates whether normal corporate incentives are enough to handle AI risks. Gates doesn’t mince words:
...very interesting & somewhat troubling deep dive look at AI, its potential dangers without control and its potential benefits. Keeping AI out of the hands of people with bad intentions will be the big challenge. nytimes.com/2026/09/29/opini…
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John De Vos retweeted
75 et 76ème rétractation pour l'IHU de Marseille. Les 63 et 64ème pour Didier Raoult.
The notorious French #fraud and bully @raoult_didier loses 2 more papers! Didier Raoult might well be the biggest French fraud ever! And @IHU_Marseille (now deleted?) involved in the biggest cover up ever in France! @lonnibesancon @MicrobiomDigest
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Finally out!!! The first ever single cell compendium of Restrictive allograft syndrome (RAS), a major cause of mortality following lung transplantation due to progressive fibrosis of the lung allograft - 👏👏 Soon to be Dr. Leiber, Prof Schupp & team 👏🏼👏🏼 publications.ersnet.org/cont…
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Fate’s #ACR2026 studies suggest #iPSC-derived #CARTs could become a compelling allogeneic platform: a potentially unlimited supply of a standardized, homogeneous product. FT819 in lupus - without conditioning/outpatient use - and CD19/CD38 FT839 in RA. firstwordpharma.com/story/79…
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John De Vos retweeted
An extraordinary @Nature paper has just landed from the lab of @Sergiu_P_Pasca at @Stanford - led by Konstantin Kaganovsky. They have found a way to create "xenocortical mice" which have ~92% of their cortex occupied by a cortical organoid derived from human stem cells. This human-derived cortical graft integrates deeply with the host nervous system, supporting organised neural activity and behaviour. This study is a milestone in synthetic biology and chimera research. It has the potential to generate multiple medical breakthroughs by providing an enhanced biological model of human brain tissue that allows behavioural as well as neural and genetic assays. The Stanford team have been exceptionally thorough and proactive in addressing ethical concerns that comes from this frontier work. But their pioneering work nonetheless raises many open questions: are the xenocortical mice conscious? Do they have any human-like properties of consciousness or cognition? @NitaFarahany and I will be addressing some of these questions in a forthcoming commentary - where we'll also offer an ethically-informed roadmap to guide this important research as it progresses. In this context, "pacing the frontier" really does make sense 😉 Read the Stanford @nature paper here, and buckle up. It's wild. nature.com/articles/s41586-0…
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Very nice review by @Joseph_C_Wu et al. on the use of #iPSCells in medicine, including manufacturing complexities. nature.com/articles/s41591-0…
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Early but promising results with armored #CARTcells targeting glypican-3 and co-expressing IL-15 and IL-21 in pediatric hepatoblastoma. Step by step, CAR-T cells are beginning to make solid tumors addressable. nejm.org/doi/pdf/10.1056/NEJ…
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