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PerrinLab - UBC (posts do not represent UBC) (@perrinlab) profile picture

PerrinLab - UBC (posts do not represent UBC)

@perrinlab

Solving Today's Biological Problems Through Chemistry

Joined May 2021
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Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)Photo by PerrinLab - UBC (posts do not represent UBC) (@perrinlab)
PerrinLab - UBC (posts do not represent UBC) retweeted
Hollenstein group (@Hollensteinlab) profile picture
Hollenstein group@Hollensteinlab16 Sep 2025
Interested by 3D modified aptamers? Then check out our recent article by undergraduate student Charlotte and postdoc Usman. nature.com/articles/s42004-0… @CNRS @institutpasteur @juliantanner1
Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection

Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection

Communications Chemistry - Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce...

nature.com
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UBC Chemistry (@UBCChem) profile picture
UBC Chemistry@UBCChem21 Aug 2025
Replying to @perrinlab
@perrinlab has developed a single-injection “dual-mode” tracer that combines PET imaging and fluorescence to help surgeons detect prostate cancer more precisely. 🔗chem.ubc.ca/new-tracer-could…
Image from UBC Chemistry (@UBCChem)
UBC Science (@ubcscience) profile pictureUBC Science@ubcscience21 Aug 2025
“Our tracer would allow a surgeon to use a hand-held Geiger counter probes to ‘hear’ areas of high radiation density that would accumulate in cancerous tissue not immediately visible," said UBC chemist Dr. David M Perrin. @UBCChem science.ubc.ca/news/2025-08/…
New tracer could enable surgeons to see and hear prostate cancer

New tracer could enable surgeons to see and hear prostate cancer

A preclinical evaluation of a new ’dual-mode’ tracer could help surgeons plan prostate cancer procedures, and provide more targeted guidance during surgery.

science.ubc.ca
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PerrinLab - UBC (posts do not represent UBC) retweeted
Ratmir Derda (@RatmirDerda) profile picture
Ratmir Derda@RatmirDerda23 Jan 2025
To distract everyone from the devastating NIH news, I recommend reading this Mirror Image Life discussion in Science magazine science.org/doi/10.1126/scie… or popular press cbc.ca/radio/thecurrent/scie… and our view on this topic: TLDR: do not forget about Glycans! biorxiv.org/content/10.1101/…
Confronting risks of mirror life

Confronting risks of mirror life

Broad discussion is needed to chart a path forward

science.org
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PerrinLab - UBC (posts do not represent UBC) retweeted
Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 (@hocekm) profile picture
Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪@hocekm23 Oct 2023
Our newest paper on superanionic DNA displaying four different anionic groups (yes, even this can be synthesized by polymerase and it can hybridize!) just published in @NAR_Open doi.org/10.1093/nar/gkad893 @IOCBPrague @Akademie_ved_CR @science_charles
Image from Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 (@hocekm)
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Angewandte Chemie (@angew_chem) profile picture
Angewandte Chemie@angew_chem20 Feb 2024
Diphenylphosphinylhydroxylamine (DPPH) Affords Late-Stage S-imination to access free-NH Sulfilimines and Sulfoximines (David M. Perrin and co-workers) @PerrinLab @UBCChem #sulfur #phosphorus #MedicinalChemistry #peptides #openaccess onlinelibrary.wiley.com/doi/…
Diphenylphosphinylhydroxylamine (DPPH) Affords Late‐Stage S‐imination to access free‐NH Sulfilimi...

Diphenylphosphinylhydroxylamine (DPPH) Affords Late‐Stage S‐imination to access free‐NH Sulfilimi...

Metal-free, and high-yielding sulfur-imination using O-(diphenylphosphinyl)hydroxyl amine to access sulfilimine salts and free-NH sulfoximines has been reported. Its generality was evidenced using a...

onlinelibrary.wiley.com
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PerrinLab - UBC (posts do not represent UBC) retweeted
Shambhu Chandra (@007_sdc) profile picture
Shambhu Chandra@007_sdc2 Jul 2023
I had the privilege of attending a week long American Peptide Symposium #APS2023. It turned out to be a great evening as I won one of The Dr. ELIZABETH A. SCHRAM AWARD 2023 young Investigator at Scottsdale Arizona. @perrinlab
Image from Shambhu Chandra (@007_sdc)
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PerrinLab - UBC (posts do not represent UBC) retweeted
Institut Pasteur, since 1887 (@institutpasteur) profile picture
Institut Pasteur, since 1887@institutpasteur24 May 2023
👨‍🔬 « Nous essayons de développer des outils thérapeutiques et diagnostiques à base d’ADN et d’ARN » rencontre avec Dr Marcel Hollenstein de l’Institut Pasteur.
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J Org Chem/Org Lett (@JOC_OL) profile picture
J Org Chem/Org Lett@JOC_OL2 Mar 2023
Hot off the press in #OrgLett: Say goodbye to HF salts! Lam and colleagues (@KLchemistry) report an electrifying method to synthesize hindered tertiary alkyl fluorides, proving that #OrganoEChem can help achieve safer, milder, and cheaper syntheses. pubs.acs.org/doi/10.1021/acs…
Image from J Org Chem/Org Lett (@JOC_OL)
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Andrei Yudin (@andrei_yudin) profile picture
Andrei Yudin@andrei_yudin22 Oct 2022
Meet Dr. Sean Huh, our most recent graduate. Sean joined our lab from ⁦@UBC⁩ where he did undergrad studies with ⁦@perrinlab⁩. He has contributed immensely to our understanding of macrocycles and we wish him luck at Paraza. I also thank Prof. John Vederas (external).
Image from Andrei Yudin (@andrei_yudin)
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PerrinLab - UBC (posts do not represent UBC) retweeted
UBC Academic Positions (@UBCAcademicJobs) profile picture
UBC Academic Positions@UBCAcademicJobs28 Sep 2022
Join UBC as PDF ✍ Postdoctoral Position in Radiopharmaceuticals - please RT! @ubcchem #cancerresearch #Postdoc #ChemTwitter #Cancer #Biology #BiologicalSciences #AcademicTwitter #postdocjobs #STEM #MedTwitter #Science #sciencejobs #Biochemistry postdocs.ubc.ca/ad/56562
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François Bénard (@frbenard) profile picture
François Bénard@frbenard15 Jun 2022
Dr. Guillaume Chaussé with the first-in-human study results of a new 18F-labeled radiopharmaceutical for neurodocrine tumour imaging (18F-AMBF3-TATE) at the SNMMI 2022 Annual Meeting. #SNMMI2022 #NeuroendocrineCancer @SNM_MI
Image from François Bénard (@frbenard)
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PerrinLab - UBC (posts do not represent UBC) retweeted
American Peptide Society (@ampepsoc) profile picture
American Peptide Society@ampepsoc14 Jun 2022
From "the neighborhood," David M Perrin with the University of British Columbia, presents his talk "Improving on Alpha-Amanitin, one of Nature’s Most Toxic Peptides – Synthesis of More Cytotoxic Analogs, Bioconjugation and Use in Peptide-Directed Targeted Therapy." #Peptides2022
Image from American Peptide Society (@ampepsoc)
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PerrinLab - UBC (posts do not represent UBC) retweeted
Ruben Arturo (@rubenR2D2) profile picture
Ruben Arturo@rubenR2D28 Jan 2022
Wait whaaaat? 😔😔 a professor of mine used to take points off for writing some of this stuff.
PerrinLab - UBC (posts do not represent UBC) (@perrinlab) profile picturePerrinLab - UBC (posts do not represent UBC)@perrinlab7 Jan 2022
Cronin lab, “filtering out forbidden structural motifs”, computes new opiates (no stereochem?!?) e.g. AP6 science.org/doi/epdf/10.1126…. Did no one catch the violation of Bredt’s rule? In SI: many fantastic examples w. motifs too unstable to isolate. Concept needs work. #chemtwitter
Image from PerrinLab - UBC (posts do not represent UBC) (@perrinlab)
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Boron-Chem-Research (@Boron_Chemistry) profile picture
Boron-Chem-Research@Boron_Chemistry17 Dec 2021
Preparation of Potassium Acyltrifluoroborates (KATs) from Carboxylic Acids by Copper-Catalyzed Borylation of Mixed Anhydrides (@Angew_chem): onlinelibrary.wiley.com/doi/… (@NealMankad, @Bode_lab).
Image from Boron-Chem-Research (@Boron_Chemistry)
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Naysilla Dayanara 👩🏻‍🔬 (she/her) (@naysilladay) profile picture
Naysilla Dayanara 👩🏻‍🔬 (she/her)@naysilladay30 Sep 2021
Congratulations to my friend and colleague, Shanal Gunasekera from the @perrinlab on winning the silver for Graduate Research Symposium Presentation Award!! 🌟 What and achievement and I can’t wait to see what the future brings! @UBCChem
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César A. Hidalgo (@cesifoti) profile picture
César A. Hidalgo
@cesifoti12 Sep 2021
After advising PhD & Master students for over a decade, there is one thing I find most students need to unlearn: the half-ass work mentality acquired during years of tests and homework. Let me explain (thread 🧵). 1/N #AcademicTwitter – at Toulouse, France
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ChemBioChem (@ChemBioChem) profile picture
ChemBioChem@ChemBioChem12 Jul 2021
Photosensitized Oxidative Dimerization at Tyrosine by a Water-Soluble 4-Amino-1,8-naphthalimide (Roberts) @agr_chemistry onlinelibrary.wiley.com/doi/…
Image from ChemBioChem (@ChemBioChem)
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Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 (@APryyma) profile picture
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦@APryyma29 Jun 2021
Honored to receive a Best Poster award at the 1st Canadian Peptide and Protein Community Symposium. Congratulations to my fellow award winners and thank you @CanadianPeptide for a chance to share my PhD research!
Image from Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 (@APryyma)
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Cheryl Arrowsmith (@CherylArrowsmi1) profile picture
Cheryl Arrowsmith@CherylArrowsmi125 Jun 2021
Check out our preprint on TMPRSS2 structure, function & inhibition. @BryanFraser19 @SerapBeldar make enzyme of unprecedented purity, specific activity with novel activity on #SARSCoV2 Spike. @francoisbenard L.Halabelian @thesgconline @UBC @UofT biorxiv.org/content/10.1101/…
Image from Cheryl Arrowsmith (@CherylArrowsmi1)
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PerrinLab - UBC (posts do not represent UBC) retweeted
Dirk H. Trauner (@DirkTrauner) profile picture
Dirk H. Trauner
@DirkTrauner18 Jun 2021
Join us on June 29 to celebrate #Pride with @uspto. Please register here: uspto.gov/about-us/events/pr… @DiversifyChem @LGBTSTEM @nyuchemistry
Image from Dirk H. Trauner (@DirkTrauner)
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