Area of interest- Proteomics and signalling pathways
Joined October 2010
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Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
I captured this video in my lab to show the power of medicines called T-cell engagers.
Left: T cells move in and out of a cancer tumoroid, largely ignoring it.
Right: Add a T-cell engager, and the T cells attack. Once they recognize their targets, they tear through the tumor.
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Did you make an #OpenScience tool using Brain Map? Submit it to our community tools page!
Tools should use Brain Map resources, extend the use of data, provide new ways to access and analyze data, or support educational use.
Learn more and submit:
bit.ly/4zTIYb9
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Rational Tuning of Intracellular Release Kinetics
in PROTAC–Peptide Conjugates via Positional Modulation of Functional
Peptide Domains pubs.acs.org/abmcb8/article/…
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses @JExpMed
@RockefellerUniv
rupress.org/jem/article-abst…
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
We are excited to announce that the Consortium for Top-Down Proteomics is relaunched as The Proteoform Alliance. Thanks to our community for building to this inflection point. Details at proteoforms.org or press release globenewswire.com/news-relea…
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Last call: Apply for the BioInnovation Institute & Science Prize for Innovation
This prize recognizes bold researchers who are asking fundamental questions at the intersection of the life sciences and entrepreneurship.
The Grand Prize winner will receive a cash prize of USD 25,000 and have their winning essay published in Science, in print and online.
Apply by 1 November 2026: bit.ly/3TuI19S
ALT The image features a logo with the words "BII Science Prize for Innovation" written in dark lettering.
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Single-cell multi-omics reveals archetypal regulatory programs shared across T cell subsets @CellReports
cell.com/cell-reports/fullte… @YuriPritykin @Princeton
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
🧠 You’ve probably heard of Alzheimer’s disease. But what about Lewy body dementia (LBD)? LBD is the second most common form of dementia, and it can affect thinking, movement, sleep, and mood.
Download or order a free booklet about LBD to learn more: bit.ly/4kg9OWi.
ALT A group of three people standing together, smiling, with one holding a clipboard. The text reads, "October is Lewy Body Dementia Awareness Month." A button below states, "Learn more about NIH resources." Logos for the U.S. Department of Health and Human Services and NIH are at the bottom.
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Tiny models. Big research potential.
Organoids are small, lab-grown models that mimic how human organs work, helping scientists better understand disease and explore new treatments. Learn how the NIH Standardized Organoid Modeling (SOM) Center is working to make these powerful research tools more reliable and accessible.
Explore the SOM Center: nih.gov/som.
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
New Article: "Rewriting wheat karyotypes through centromere-targeted chromosome engineering" rdcu.be/M5dMQ9xEboMa
Centromere editing in wheat drives extensive, heritable rearrangements across multiple chromosomes; for engineering complex karyotypes in polyploid crops.
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Online Now: The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer dlvr.it/TW48Xs
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
"By using human neural organoids, we created a map of how different hormonal signals can change how developing neural cells behave in a physiologically relevant human model." Read the article from @gtesta72, @NicoloCaporale and colleagues: hubs.ly/Q04zXr710
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
What can a researcher in an overworked laboratory do to take care of themselves and their lab-mates, and how should they navigate medical disclosure?
go.nature.com/4yCFfhc
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
The discovery of 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 has advanced the prevention and treatment of gastritis, peptic ulcers, and gastric cancer. Progress has been made in the research of 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 infection. These advances are discussed in a new review.
Read the Review Article “𝘏𝘦𝘭𝘪𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳 𝘱𝘺𝘭𝘰𝘳𝘪 Infection — Advances, Challenges, and the Road Ahead” by Hong Li, MD, PhD, Francis Megraud, MD, and Barry J. Marshall, MD: nej.md/4Bj3O58
ALT An illustrated diagram shows the pathogenesis of H. pylori infection. Includes sections on colonization, immune evasion, and the immune response, with details on disruption of cell junctions, inflammation, and apoptosis.
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Borrowing an idea from one research discipline to solve a thorny problem in another is an age-old scientific trick. Charles Darwin’s theory of natural selection, for example, famously inspired algorithms in computer science that “evolve” solutions to complex problems.
But such clever leaps are fleetingly rare. For #AI, however, hopping between fields can be a breeze.
Researchers highlighted that ability with the release of 36 preprints produced with a single suite of AI tools called BootLoops. The so-called harness can be used with any large language model, such as Anthropic’s Claude or OpenAI’s ChatGPT.
And in just 3 months, researchers used Claude outfitted with BootLoops to cross-pollinate at a massive scale, spotting—and precisely solving—problems in seemingly unrelated fields that share the same mathematical structures.
The resulting papers range widely, from figuring out the age of sunspots, to analyzing government health policies, to attempting to decipher a mysterious medieval manuscript.
Learn more: scim.ag/3TUUyDJ
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Nature research paper: The anatomy of a personal health agent
go.nature.com/4Bl56wH
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
When you type an unpublished idea into a chatbot or coding agent, could it end up being used by the company that built the model—or a rival who asks the right question a year later? And what can you do to reduce the risk?
No setting makes a chatbot fully private, but experts suggest steps that can make leaks much less likely: scim.ag/4sihqtz
ALT Could your chatbot tip off a scientific rival? It’s possible, researchers say
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Online Now! Immunoids: Building immunocompetent organoids from human pluripotent stem cells dlvr.it/TVdHYM #stemcells
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Can immunology still surprise itself? dlvr.it/TV8YM0
Dr. Rex Devasahayam Arokia Balaya, MPhil., Ph.D. retweeted
Introducing the BRaVa results browser v1! 🎉
1.2M+ individuals across 10 global biobanks
44 heritable, disease-relevant traits (and counting)
419M gene- & variant-level association tests
➡️ nikbaya.github.io/brava_brow…