https://nitter.gq/t.co/rQjFOdW62m, PhD IIT Kharagpur| Former Visiting Fellow-NHLBI, NIH| Hematology research|Flute fanatic| Love sculpting & hiking| Insta: devdeep_mukhopadhyay
Roopkund
Joined October 2009
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Devdeep Mukhopadhyay retweeted
Thrilled to share our work on the role of taurine in myeloid leukemia progression in @nature today! nature.com/articles/s41586-0…
Devdeep Mukhopadhyay retweeted
Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human development! biorxiv.org/content/10.1101/…. Read on for more 🧵 [1/16]
Devdeep Mukhopadhyay retweeted
📢 New KFW Lab paper out now in @ScienceAdvances! 📢
We show that AML cells resist chemotherapy by reversing the ATP synthase reaction—supporting oxidative metabolism and maintaining mitochondrial membrane potential. 🔬🧬
👉 science.org/doi/10.1126/scia…
Devdeep Mukhopadhyay retweeted
A single molecule provides a controllable connection between a normal metal and a superconductor
Letter: go.aps.org/4cAmz8w
Focus: go.aps.org/3G0ETLL
Devdeep Mukhopadhyay retweeted
T cell-derived interleukin-9 potentiates differentiation of GC memory precursors into functional memory B cells in a manner dependent on the transcriptional regulator ZBTB18 @ImmunityCP
cell.com/immunity/fulltext/S… on
cell.com/immunity/fulltext/S…
Devdeep Mukhopadhyay retweeted
In a phase 1 trial, patients with AML treated with CD123 CAR T therapy experienced high levels of cytokine release syndrome and short lived clinical responses, likely due to CAR T-derived cytokines increasing viability of blasts. nature.com/articles/s41591-0…
Devdeep Mukhopadhyay retweeted
The heart in a zebrafish embryo videoed through a microscope. 72 hour post fertilization (hpf). #CellBiology
Devdeep Mukhopadhyay retweeted
UNREAL!!! Unedited iPhone shots from Watertown, South Dakota!! Easily the deepest reds I’ve ever seen in the aurora! Still going!! #aurora
Devdeep Mukhopadhyay retweeted
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Devdeep Mukhopadhyay retweeted
Why do AML patients with African ancestry have poor outcomes? Fascinating results indicate that genetics alter AML biology. Also, its Bailee Kain's first co-first author postdoc pub. @Bailee_Kain @AkEisfeld @nsalomonis and Elaine Mardis
nature.com/articles/s41588-0…
Devdeep Mukhopadhyay retweeted
Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10
@PennMedicine @CHOP_Research @GillSaar nature.com/articles/s41591-0…
Devdeep Mukhopadhyay retweeted
Congratulations to Team India 🇮🇳♥️
They have played exceptional will throughout the Chess Olympiad 2024 ✨
Devdeep Mukhopadhyay retweeted
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s41586-0…
Devdeep Mukhopadhyay retweeted
A video of the Danish percussion duo Safri Duo performing the "Interstellar" theme
Devdeep Mukhopadhyay retweeted
Out today from the Vandenberg and Dedecker labs! PSF splitting with the ‘Circulator’, which encodes the fluorophore emission band into the PSF, improves the information content of fluorescence microscopy and enables improved super-resolution imaging and single-particle tracking.
Devdeep Mukhopadhyay retweeted
Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells go.nature.com/3XeDg1Q
Devdeep Mukhopadhyay retweeted
We report many proteins not predicted by the genetic code.
They are stable & abundant O( 10³ ) copies / cell.
Generative mechanisms include codon-anticodon mismatches & RNA modifications.
Their abundance depends on codon frequency & protein stability.
biorxiv.org/content/10.1101/…
Devdeep Mukhopadhyay retweeted
just for the pleasure of it, the fine choreography of epithelial cell migration with a PI3K mutation. This is the complex behavior we have to drug to treat cancer ... Movie from @lhinderling . Switch sound on.
Devdeep Mukhopadhyay retweeted
Thrilled to share our latest work in Science. We discovered a novel non-mobilizable HSC pool. I really appreciate the huge support from @SteidlUli @The_Will_Lab and all the co-authors. I hope Paul is smiling at all of us from above! science.org/doi/10.1126/scie…
Devdeep Mukhopadhyay retweeted
I am beyond excited to have the first paper from my postdoc here at @EinsteinMed published today in Science! This is such a cool story... 🧵
science.org/doi/10.1126/scie…